Results 1 to 10 of about 7,724 (208)

Pancancer Analyses of KISS1 as a Potential Biomarker for Tumor Metastasis and Immunotherapy and Therapeutic Target for Breast Cancer [PDF]

International Journal of Genomics
Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy.
Chunbiao Wu, Hao Jiang, Wei Xu, Bo Li, Hao Zhang, Long Zhang, Zhenxi Li, Jianru Xiao   +7 more
doaj   +3 more sources

A dual fluorescence reporter system for high throughput screening of effectors of Kiss1 gene expression [PDF]

FEBS Open Bio, 2018
Kisspeptin is a multifunctional peptide encoded by the Kiss1 gene that plays critical roles in mammalian puberty onset modulation and fertility maintenance in the hypothalamus.
Xiaoning Li, Sijia Wang, Yanhua Lu, Huanhuan Yin, Junhua Xiao, Kai Li, Lei Ma, Yuxun Zhou   +7 more
doaj   +2 more sources

Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches. [PDF]

Reprod Domest Anim
ABSTRACT Kisspeptin is a peptide that plays a pivotal role in the central regulation of gonadotropins. It is regarded as a key regulator of reproductive processes, including follicular and luteal development and endometrial remodelling. The objective of this study was to investigate the expression of KISS1, its receptor KISS1R and the proliferation ...
Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Özmen Ö, Bozkurt G, Taşan Ş.   +4 more
europepmc   +2 more sources

Neuroendocrine plasticity and crosstalk in pubertal development. [PDF]

J Neuroendocrinol
Abstract Puberty is a critical developmental stage during which individuals acquire the capacity for sexual reproduction. This transition involves a series of complex biological events primarily orchestrated by the activation of the hypothalamo–pituitary–gonadal (HPG) axis.
Elias CF, Han X, Garcia-Galiano D, Sáenz de Miera C.   +3 more
europepmc   +2 more sources

STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells [PDF]

Journal of Ovarian Research, 2020
Background In mammals, it is known that the estradiol-17β (E2) is mainly synthetized in ovarian granulosa cells (GCs), and the excessive apoptosis of GCs induces the follicular atresia.
Yao Jiang, Xiaoping Xin, Xiangchun Pan, Ailing Zhang, Zhe Zhang, Jiaqi Li, Xiaolong Yuan   +6 more
doaj   +2 more sources

KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]

J Neuroendocrinol
Abstract Neurons in the arcuate nucleus of the hypothalamus (ARH) that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy neurons) are considered the gonadotropin‐releasing hormone (GnRH) pulse generator necessary for fertility. KNDy neurons are also metabolic sensors controlling the hypothalamic–pituitary‐gonadal (HPG) axis.
Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT, Moore AM, Donato J, Frazao R.   +8 more
europepmc   +2 more sources

Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models [PDF]

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) and mental health disorders have high rates of co-occurrence. Although the precise pathophysiological mechanisms remain unknown, the observed changes in those conditions may be modulated by kisspeptin (Kiss1), a protein ...
Tingting Mo, Yue Qiu, Shuangshuang He, Guibin Wang, Bingbing Li, Qian Shen, Xiaowei Nie, Jiali Wei, Nachuan Li, Bo Pang, Yanfeng Liu, Xue Pan   +11 more
doaj   +2 more sources

KISS1 Suppresses Apoptosis and Stimulates the Synthesis of E2 in Porcine Ovarian Granulosa Cells

Animals, 2019
Previous studies have strongly recommended that KISS-1 metastasis suppressor (KISS1) plays an essential gatekeeper of the initiation of reproductive maturation in mammals.
Xiaoping Xin, Yuyi Zhong, Xiaolong Yuan   +2 more
exaly   +3 more sources

The gatekeepers of growth: The neural roles and regulation of growth hormone-releasing hormone neurons. [PDF]

J Neuroendocrinol
Abstract The neuroendocrine control of growth is mediated by the hypothalamic–pituitary–somatic (HPS) axis. This involves the hypothalamic release of growth hormone‐releasing hormone (GHRH), which stimulates the pituitary secretion of growth hormone (GH).
Jamieson BB.
europepmc   +2 more sources

Evolutionary Insights into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain

Frontiers in Endocrinology, 2012
Kisspeptin was originally found as a peptide product of Kiss1gene and is now supposed to be an essential central regulator of reproduction in mammals. However, there is now a growing body of evidence to suggest that kiss2, the paralogous gene for kiss1 ...
Shinji Kanda, Yoshitaka Oka
exaly   +3 more sources