Results 1 to 10 of about 7,018 (135)

Kiss1-FASN participates fatty acid synthesis via high-fat diet in PgVAT of female mice [PDF]

Journal of Lipid Research
Long-term consumption of high-fat diet (HFD) leads to energy surplus, resulting in excessive adipose tissue (AT) accumulation and dysfunction. Kiss1 is known to play a role in the metabolic regulation of AT.
Xuehan Li, Chunyu Liang, Ge Song, Yihsuan Lin, Yue Chen, Jiani Zhao, Hongtao Sui, Xinliang Pan, Lingyu Sun, Jianhao Chen, Jiaqi Li, Zhen Ni, Yi Yan   +12 more
doaj   +2 more sources

Pancancer Analyses of KISS1 as a Potential Biomarker for Tumor Metastasis and Immunotherapy and Therapeutic Target for Breast Cancer [PDF]

International Journal of Genomics
Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy.
Chunbiao Wu, Hao Jiang, Wei Xu, Bo Li, Hao Zhang, Long Zhang, Zhenxi Li, Jianru Xiao   +7 more
doaj   +2 more sources

Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches. [PDF]

Reprod Domest Anim
ABSTRACT Kisspeptin is a peptide that plays a pivotal role in the central regulation of gonadotropins. It is regarded as a key regulator of reproductive processes, including follicular and luteal development and endometrial remodelling. The objective of this study was to investigate the expression of KISS1, its receptor KISS1R and the proliferation ...
Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Özmen Ö, Bozkurt G, Taşan Ş.   +4 more
europepmc   +2 more sources

Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models [PDF]

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) and mental health disorders have high rates of co-occurrence. Although the precise pathophysiological mechanisms remain unknown, the observed changes in those conditions may be modulated by kisspeptin (Kiss1), a protein ...
Tingting Mo, Yue Qiu, Shuangshuang He, Guibin Wang, Bingbing Li, Qian Shen, Xiaowei Nie, Jiali Wei, Nachuan Li, Bo Pang, Yanfeng Liu, Xue Pan   +11 more
doaj   +2 more sources

Genetic and epigenetic aspects of the and genes in pubertal development and central precocious puberty: A review [PDF]

Precision and Future Medicine, 2023
The onset of puberty is a pivotal developmental milestone, and the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone is a key factor in the initiation of puberty. Both kisspeptin and its receptor (KISS1) and KISS1 receptor (KISS1R)
Ahreum Kwon
doaj   +1 more source

Sex difference in developmental changes in visualized Kiss1 neurons in newly generated Kiss1-Cre rats

The Journal of Reproduction and Development, 2023
Hypothalamic kisspeptin neurons are master regulators of mammalian reproduction via direct stimulation of gonadotropin-releasing hormone and consequent gonadotropin release.
Koki YAMADA, Mayuko NAGAE, Tetsuya MANO, Hitomi TSUCHIDA, Safiullah HAZIM, Teppei GOTO, Makoto SANBO, Masumi HIRABAYASHI, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA   +10 more
doaj   +1 more source

The molecular phenotype of kisspeptin neurons in the medial amygdala of female mice

Frontiers in Endocrinology, 2023
Reproduction is regulated through the hypothalamic-pituitary-gonadal (HPG) axis, largely via the action of kisspeptin neurons in the hypothalamus. Importantly, Kiss1 neurons have been identified in other brain regions, including the medial amygdala (MeA).
Katherine M. Hatcher, Leah Costanza, Alexander S. Kauffman, Shannon B. Z. Stephens, Shannon B. Z. Stephens   +4 more
doaj   +1 more source

CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait

Frontiers in Genetics, 2023
Introduction: Most male pigs are surgically castrated to avoid puberty-derived boar taint and aggressiveness. However, this surgical intervention represents a welfare concern in swine production.
Julio M. Flórez, Julio M. Flórez, Kyra Martins, Staci Solin, Jonathan R. Bostrom, Paula Rodríguez-Villamil, Felipe Ongaratto, Sabreena A. Larson, Uyanga Ganbaatar, Alexander W. Coutts, Doug Kern, Thomas W. Murphy, Eui-Soo Kim, Daniel F. Carlson, Abe Huisman, Tad S. Sonstegard, Clay A. Lents   +16 more
doaj   +1 more source

Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that kisspeptin-GPR54 signaling is indispensable for gonadotropin-releasing hormone (GnRH)/gonadotropin secretion and consequent reproductive functions in mammals. Conventional Kiss1 knockout (KO) mice and rats are reported
Shiori MINABE, Sho NAKAMURA, Eri FUKUSHIMA, Marimo SATO, Kana IKEGAMI, Teppei GOTO, Makoto SANBO, Masumi HIRABAYASHI, Junko TOMIKAWA, Takuya IMAMURA, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-Ichiro MAEDA, Fuko MATSUDA   +14 more
doaj   +1 more source

Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. [PDF]

PLoS ONE, 2014
KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging ...
Sitaram Harihar, Keke M Pounds, Tomoo Iwakuma, Nabil G Seidah, Danny R Welch   +4 more
doaj   +1 more source