Results 1 to 10 of about 8,886 (197)

Evolutionary Insights Into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain [PDF]

Frontiers in Endocrinology, 2012
Kisspeptin was originally found as a peptide product of Kiss1gene and is now supposed to be an essential central regulator of reproduction in mammals. However, there is now a growing body of evidence to suggest that kiss2, the paralogous gene for kiss1 ...
Shinji Kanda, Yoshitaka Oka
exaly   +4 more sources

Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice. [PDF]

J Neuroendocrinol
Abstract Kisspeptin neurons in the rostral hypothalamus are hypothesized to initiate preovulatory gonadotropin‐releasing hormone (GnRH) surges by causing estradiol‐dependent activation of GnRH neuron action potential firing and subsequent GnRH release.
Starrett JR, Chen X, Krasner D, Phillips CD, Moenter SM.   +4 more
europepmc   +2 more sources

Sex difference in developmental changes in visualized Kiss1 neurons in newly generated Kiss1-Cre rats

The Journal of Reproduction and Development, 2023
Hypothalamic kisspeptin neurons are master regulators of mammalian reproduction via direct stimulation of gonadotropin-releasing hormone and consequent gonadotropin release.
Koki YAMADA, Mayuko NAGAE, Tetsuya MANO, Hitomi TSUCHIDA, Safiullah HAZIM, Teppei GOTO, Makoto SANBO, Masumi HIRABAYASHI, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA   +10 more
doaj   +3 more sources

RETRACTION: Up-regulation of KISS1 as a Novel Target of Let-7i in Melanoma Serves as a Potential Suppressor of Migration and Proliferation In Vitro. [PDF]

J Cell Mol Med
Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
europepmc   +2 more sources

Pancancer Analyses of KISS1 as a Potential Biomarker for Tumor Metastasis and Immunotherapy and Therapeutic Target for Breast Cancer [PDF]

International Journal of Genomics
Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy.
Chunbiao Wu, Hao Jiang, Wei Xu, Bo Li, Hao Zhang, Long Zhang, Zhenxi Li, Jianru Xiao   +7 more
doaj   +2 more sources

Kiss1-FASN participates fatty acid synthesis via high-fat diet in PgVAT of female mice [PDF]

Journal of Lipid Research
Long-term consumption of high-fat diet (HFD) leads to energy surplus, resulting in excessive adipose tissue (AT) accumulation and dysfunction. Kiss1 is known to play a role in the metabolic regulation of AT.
Xuehan Li, Chunyu Liang, Ge Song, Yihsuan Lin, Yue Chen, Jiani Zhao, Hongtao Sui, Xinliang Pan, Lingyu Sun, Jianhao Chen, Jiaqi Li, Zhen Ni, Yi Yan   +12 more
doaj   +2 more sources

Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice. [PDF]

J Neuroendocrinol
Abstract Stress impairs reproduction, at least in part, by inhibition of Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells and suppression of gonadotropin secretion. However, the mechanism for this inhibition is not clear. Neuropeptide Y (NPY) is a pleiotropic molecule that is produced in neurons throughout the brain and mediates several physiological ...
Young LA, Hurtado ER, Jacobs KD, Lee ZMM, Nestor CC, McCosh RB.   +5 more
europepmc   +2 more sources

Divergent effects of hyperandrogenemia on the female reproductive neuroendocrine axis under different physiological conditions. [PDF]

J Neuroendocrinol
Abstract The hypothalamic–pituitary–gonadal (HPG) axis coordinates reproductive function and incorporates gonadal sex steroid feedback to regulate gonadotropin secretion in a homeostatic manner. In females, ovarian estrogens and progestins act as the primary negative feedback signals to suppress luteinizing hormone (LH) release, whereas in males ...
Rose L, Kauffman AS.
europepmc   +2 more sources

Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models [PDF]

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) and mental health disorders have high rates of co-occurrence. Although the precise pathophysiological mechanisms remain unknown, the observed changes in those conditions may be modulated by kisspeptin (Kiss1), a protein ...
Tingting Mo, Yue Qiu, Shuangshuang He, Guibin Wang, Bingbing Li, Qian Shen, Xiaowei Nie, Jiali Wei, Nachuan Li, Bo Pang, Yanfeng Liu, Xue Pan   +11 more
doaj   +2 more sources

Genetic and epigenetic aspects of the and genes in pubertal development and central precocious puberty: A review [PDF]

Precision and Future Medicine, 2023
The onset of puberty is a pivotal developmental milestone, and the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone is a key factor in the initiation of puberty. Both kisspeptin and its receptor (KISS1) and KISS1 receptor (KISS1R)
Ahreum Kwon
doaj   +1 more source