Results 21 to 30 of about 8,886 (197)

KISS1 metastasis suppression and emergent pathways

Clinical & Experimental Metastasis, 2003
Metastatic disease is the most critical impediment to cancer patient survival. However, comparatively little is known concerning the intricate pathways which govern the complex phenotypes associated with metastasis. The KISS1 metastasis suppressor gene inhibits metastasis in both in vivo melanoma and breast carcinoma models.
John F, Harms, Danny R, Welch, Mary E, Miele   +2 more
openaire   +3 more sources

Role of Kiss1 in serotonergic modulation in the zebrafish

, 2017
KISS1/Kiss1 gene produces a neuropeptide, kisspeptin with the ability to activate its G-protein coupled receptor, GPR54 (Kiss-R), which is involved in the control of vertebrate reproduction. Previously, two forms of genes encoding kisspeptin (kiss1 and kiss2) and its respective receptor (kissr1 and kissr2) were identified in the zebrafish (Danio rerio).
Nathan , Fatima Megala (3770320)
openaire   +2 more sources

The molecular phenotype of kisspeptin neurons in the medial amygdala of female mice

Frontiers in Endocrinology, 2023
Reproduction is regulated through the hypothalamic-pituitary-gonadal (HPG) axis, largely via the action of kisspeptin neurons in the hypothalamus. Importantly, Kiss1 neurons have been identified in other brain regions, including the medial amygdala (MeA).
Katherine M. Hatcher, Leah Costanza, Alexander S. Kauffman, Shannon B. Z. Stephens, Shannon B. Z. Stephens   +4 more
doaj   +1 more source

Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that kisspeptin-GPR54 signaling is indispensable for gonadotropin-releasing hormone (GnRH)/gonadotropin secretion and consequent reproductive functions in mammals. Conventional Kiss1 knockout (KO) mice and rats are reported
Shiori MINABE, Sho NAKAMURA, Eri FUKUSHIMA, Marimo SATO, Kana IKEGAMI, Teppei GOTO, Makoto SANBO, Masumi HIRABAYASHI, Junko TOMIKAWA, Takuya IMAMURA, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-Ichiro MAEDA, Fuko MATSUDA   +14 more
doaj   +1 more source

Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. [PDF]

PLoS ONE, 2014
KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging ...
Sitaram Harihar, Keke M Pounds, Tomoo Iwakuma, Nabil G Seidah, Danny R Welch   +4 more
doaj   +1 more source

Visualisation of Kiss1 Neurone Distribution Using a Kiss1‐CRE Transgenic Mouse [PDF]

Journal of Neuroendocrinology, 2016
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in the regulation of the mammalian reproductive axis. Kiss1 neurones are found in two locations in the rodent hypothalamus: one in the arcuate nucleus (ARC) and another in the RP3V region, which includes the anteroventral periventricular nucleus (AVPV).
Yeo, SH, Kyle, V, Morris, PG, Jackman, S, Sinnett-Smith, LC, Schacker, M, Chen, C, Colledge, W. H.   +7 more
openaire   +5 more sources

Serum Kisspeptin Level in normal pregnancy and preeclampsia with and without obesity [PDF]

Zagazig University Medical Journal, 2021
Background:kisspeptin(kiss1) is a hypothalamic neuropeptide, expressed also peripherally in the placental trophoblast, pancreatic cells, liver and adipose tissue suggesting its role in regulating metabolic homeostasis as well as normal fetal implantation
ali asalah, Mohamed El-Sayed, dalia Abdel-Aleem, Walid EL Nagar, Amira Gobran   +4 more
doaj   +1 more source

Kisspeptin-mediated improvement of sensitivity to BRAF inhibitors in vemurafenib-resistant melanoma cells

Frontiers in Oncology, 2023
Metastatic dissemination is still one of the major causes of death of melanoma’s patients. KiSS1 is a metastasis suppressor originally identified in melanoma cells, known to play an important physiological role in mammals’ development and puberty. It has
Carlotta Guzzetti, Cristina Corno, Elisabetta Vergani, Luca Mirra, Emilio Ciusani, Monica Rodolfo, Paola Perego, Giovanni L. Beretta   +7 more
doaj   +1 more source

Transcriptional regulation of the human KiSS1 gene [PDF]

Molecular and Cellular Endocrinology, 2011
Kisspeptin, the product of the KiSS1 gene, has emerged as a key component of the mechanism by which the hypothalamus controls puberty and reproductive development. It does so by stimulating the secretion of gonadotropin releasing hormone (GnRH). Little is known about the transcriptional control of the KiSS1 gene.
Johanna K, Mueller, Anja, Dietzel, Alejandro, Lomniczi, Alberto, Loche, Katrin, Tefs, Wieland, Kiess, Thomas, Danne, Sergio R, Ojeda, Sabine, Heger   +8 more
openaire   +2 more sources

Altered placental expression of kisspeptin and its receptor in pre-eclampsia [PDF]

, 2012
Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy.
Williams, Paula Juliet, Cartwright, JE, Williams, PJ, Cartwright, Judith E.   +3 more
core   +1 more source