Results 41 to 50 of about 7,724 (208)

Redundancy in Kiss1 Expression Safeguards Reproduction in the Mouse [PDF]

Endocrinology, 2013
Kisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a prerequisite for puberty and reproduction. Animals lacking functional genes for either kisspeptin or its receptor exhibit low gonadotropin secretion and infertility. Paradoxically, a recent study reported that genetic ablation of nearly all Kiss1-expressing neurons (Kiss1 ...
Popa, Simina M., Moriyama, Ryutaro M., Caligioni, Claudia S., Yang, Jasmine J., Cho, Caroline M., Concepcion, Tessa L., Oakley, Amy E., Lee, In Hae, Sanz, Elisenda, Amieux, Paul S., Caraty, Alain, Palmiter, Richard D., Navarro, Victor M., Chan, Yee-Ming, Seminara, Stephanie B., Clifton, Donald K., Steiner, Robert A   +16 more
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Novel insights into the metabolic action of Kiss1 neurons [PDF]

Endocrine Connections, 2020
Kiss1 neurons are essential regulators of the hypothalamic–pituitary–gonadal (HPG) axis by regulating gonadotropin-releasing hormone (GnRH) release. Compelling evidence suggests that Kiss1 neurons of the arcuate nucleus (Kiss1ARC), recently identified as the hypothalamic GnRH pulse generator driving fertility, also participate in the regulation of ...
Rajae Talbi, Victor M Navarro
openaire   +2 more sources

Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice

Nature Communications, 2022
Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of ...
Juan Roa, Miguel Ruiz-Cruz, Francisco Ruiz-Pino, Rocio Onieva, Maria J. Vazquez, Maria J. Sanchez-Tapia, Jose M. Ruiz-Rodriguez, Veronica Sobrino, Alexia Barroso, Violeta Heras, Inmaculada Velasco, Cecilia Perdices-Lopez, Claes Ohlsson, Maria Soledad Avendaño, Vincent Prevot, Matti Poutanen, Leonor Pinilla, Francisco Gaytan, Manuel Tena-Sempere   +18 more
doaj   +1 more source

Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). [PDF]

PLoS ONE, 2014
Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals.
Yali Zhao, Meng-Chin A Lin, Allan Mock, Ming Yang, Nancy L Wayne   +4 more
doaj   +1 more source

Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer [PDF]

International Journal of Environmental Research and Public Health, 2019
Epigenetics describes how both lifestyle and environment may affect human health through the modulation of genome functions and without any change to the DNA nucleotide sequence. The discovery of several epigenetic mechanisms and the possibility to deliver epigenetic marks in cells, gametes, and biological fluids has opened up new perspectives in the ...
Maria Letizia Motti, Rosaria Meccariello
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KiSS1 inhibits growth and invasion of osteosarcoma cells through inhibition of the MAPK pathway

European Journal of Histochemistry, 2013
As a metastasis suppressor, KiSS1 has been implicated in numerous human cancers. However, recent studies have demonstrated that KiSS1 promotes tumor growth and metastasis in breast cancer, and it is unclear about the expression and function of KiSS1 in ...
Y. Zhang, Y.J. Tang, Z.H. Li, F. Pan, K. Huang, G.H. Xu   +5 more
doaj   +1 more source

Estradiol modulates Kiss1 neuronal response to ghrelin [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2014
Ghrelin is a metabolic signal regulating energy homeostasis. Circulating ghrelin levels rise during starvation and fall after a meal, and therefore, ghrelin may function as a signal of negative energy balance. Ghrelin may also act as a modulator of reproductive physiology, as acute ghrelin administration suppresses gonadotropin secretion and inhibits ...
Renata, Frazao, Heather M, Dungan Lemko, Regina P, da Silva, Dhirender V, Ratra, Charlotte E, Lee, Kevin W, Williams, Jeffrey M, Zigman, Carol F, Elias   +7 more
openaire   +2 more sources

Upregulation of Kiss-1 and Gpr54 Genes Expression in Pituitary of Male Rats Following the Central Administration of Neuropeptide Y [PDF]

International Journal of Basic Science in Medicine, 2019
Introduction: The neuropeptide Y (NPY) in the neural circuits of the hypothalamus has a stimulating effect on reproductive activities in mammals. Kisspeptin (KiSS1) is a quintessential neurotransmitter in the reproductive axis which directly stimulates ...
Vahid Azizi, Shahrbanoo Oryan, Homayuon Khazali, Abdolkarim Hosseini   +3 more
doaj   +1 more source

Serum kisspeptin levels mainly depend on ovarian expression of Kiss1 mRNA in female rats

Frontiers in Physiology, 2022
The hypothalamic kisspeptin/KISS1 receptor system is essential for puberty onset and reproductive development. Although serum kisspeptin might be associated with puberty, its levels, according to developmental stage, and its origin still remain unclear ...
Ahreum Kwon, Ji Young Eom, Woo Jung Lee, Han Saem Choi, Kyungchul Song, Junghwan Suh, Hyun Wook Chae, Ho-Seong Kim   +7 more
doaj   +1 more source

Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats

The Journal of Reproduction and Development
Hypothalamic arcuate (ARC) kisspeptin neurons are considered the gonadotropin-releasing hormone pulse generator in rats. In virgin rats, the expression of the ARC kisspeptin gene (Kiss1) is repressed by proestrous levels of estradiol-17β (high E2) but ...
Marina TAKIZAWA, Sae MIYAZAKI, Hitomi TSUCHIDA, Mayuko NAGAE, Shunsuke SEKI, Masumi HIRABAYASHI, Fumitaka OSAKADA, Naoko INOUE, Hiroko TSUKAMURA, Yoshihisa UENOYAMA   +9 more
doaj   +1 more source