Results 41 to 50 of about 8,330 (205)

Estradiol modulates Kiss1 neuronal response to ghrelin [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2014
Ghrelin is a metabolic signal regulating energy homeostasis. Circulating ghrelin levels rise during starvation and fall after a meal, and therefore, ghrelin may function as a signal of negative energy balance. Ghrelin may also act as a modulator of reproductive physiology, as acute ghrelin administration suppresses gonadotropin secretion and inhibits ...
Renata, Frazao, Heather M, Dungan Lemko, Regina P, da Silva, Dhirender V, Ratra, Charlotte E, Lee, Kevin W, Williams, Jeffrey M, Zigman, Carol F, Elias   +7 more
openaire   +2 more sources

Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). [PDF]

PLoS ONE, 2014
Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals.
Yali Zhao, Meng-Chin A Lin, Allan Mock, Ming Yang, Nancy L Wayne   +4 more
doaj   +1 more source

Serum kisspeptin levels mainly depend on ovarian expression of Kiss1 mRNA in female rats

Frontiers in Physiology, 2022
The hypothalamic kisspeptin/KISS1 receptor system is essential for puberty onset and reproductive development. Although serum kisspeptin might be associated with puberty, its levels, according to developmental stage, and its origin still remain unclear ...
Ahreum Kwon, Ji Young Eom, Woo Jung Lee, Han Saem Choi, Kyungchul Song, Junghwan Suh, Hyun Wook Chae, Ho-Seong Kim   +7 more
doaj   +1 more source

Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents

The Journal of Reproduction and Development, 2020
Kisspeptin, encoded by Kiss1, is essential for reproduction in mammals. Kiss1 expression is regulated by estrogen via histone acetylation in the Kiss1 promotor region.
Kei HORIHATA, Naoko INOUE, Yoshihisa UENOYAMA, Kei-ichiro MAEDA, Hiroko TSUKAMURA   +4 more
doaj   +1 more source

Upregulation of Kiss-1 and Gpr54 Genes Expression in Pituitary of Male Rats Following the Central Administration of Neuropeptide Y [PDF]

International Journal of Basic Science in Medicine, 2019
Introduction: The neuropeptide Y (NPY) in the neural circuits of the hypothalamus has a stimulating effect on reproductive activities in mammals. Kisspeptin (KiSS1) is a quintessential neurotransmitter in the reproductive axis which directly stimulates ...
Vahid Azizi, Shahrbanoo Oryan, Homayuon Khazali, Abdolkarim Hosseini   +3 more
doaj   +1 more source

Kiss1-PgrKO mice have impaired kisspeptin-mediated GnRH release.

, 2016
A. Serum LH before and after stimulation of kisspeptin neurons by exogenous administration of estradiol in 6-8-month-old ovariectomized WT and Kiss1-PgrKO mice (n = 3); a represent statistical difference between WT, and b represents statistical ...
Andrew Wolfe (703417), Carol F. Elias (386291), Arnon Gal (3150036), Patrick R. Hannon (3150039), Megan M. Mahoney (3150042), John P. Lydon (476343), Joseph A. Cacioppo (555398), Rodrigo Fernandez-Valdivia (3150030), CheMyong Ko (3150045), Po-Ching Lin (3150033)   +9 more
core   +1 more source

Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats

The Journal of Reproduction and Development
Hypothalamic arcuate (ARC) kisspeptin neurons are considered the gonadotropin-releasing hormone pulse generator in rats. In virgin rats, the expression of the ARC kisspeptin gene (Kiss1) is repressed by proestrous levels of estradiol-17β (high E2) but ...
Marina TAKIZAWA, Sae MIYAZAKI, Hitomi TSUCHIDA, Mayuko NAGAE, Shunsuke SEKI, Masumi HIRABAYASHI, Fumitaka OSAKADA, Naoko INOUE, Hiroko TSUKAMURA, Yoshihisa UENOYAMA   +9 more
doaj   +1 more source

KISS1 in breast cancer progression and autophagy

Cancer and Metastasis Reviews, 2019
Tumor suppressors are cellular proteins typically expressed in normal (non-cancer) cells that not only regulate such cellular functions as proliferation, migration and adhesion, but can also be secreted into extracellular space and serve as biomarkers for pathological conditions or tumor progression.
Ilya V, Ulasov, Anton V, Borovjagin, Peter, Timashev, Massimo, Cristofanili, Danny R, Welch   +4 more
openaire   +3 more sources

Molecular cloning and characterization of KISS1 promoter and effect of KISS1 gene mutations on litter size in the goat

Genetics and Molecular Research, 2013
Kisspeptins, the product of the KISS1 gene, play an essential role in the regulation of reproductive functions, acting primarily at the hypothalamic level of the gonadotropic axis. We detected polymorphisms of the goat KISS1 gene in 723 individuals from three goat breeds (Xinong Saanen, Guanzhong, and Boer) by DNA pooling, PCR-RFLP, and DNA sequencing ...
X P, An, P, Han, J X, Hou, H B, Zhao, Y, Yan, T, Ma, F, Fang, F X, Meng, Y X, Song, J G, Wang, B Y, Cao   +10 more
openaire   +2 more sources

Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse.

PLoS ONE, 2019
The normal function of the mammalian reproductive axis is strongly influenced by physiological, metabolic and environmental factors. Kisspeptin neuropeptides, encoded by the Kiss1 gene, are potent regulators of the mammalian reproductive axis by ...
Shel-Hwa Yeo, Victoria Kyle, Clemence Blouet, Susan Jones, William Henry Colledge   +4 more
doaj   +1 more source