Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). [PDF]
PLoS ONE, 2014 Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals.
Yali Zhao +4 more
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Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer [PDF]
International Journal of Environmental Research and Public Health, 2019 Epigenetics describes how both lifestyle and environment may affect human health through the modulation of genome functions and without any change to the DNA nucleotide sequence. The discovery of several epigenetic mechanisms and the possibility to deliver epigenetic marks in cells, gametes, and biological fluids has opened up new perspectives in the ...
Maria Letizia Motti, Rosaria Meccariello
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STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells
Journal of Ovarian Research, 2020 Background In mammals, it is known that the estradiol-17β (E2) is mainly synthetized in ovarian granulosa cells (GCs), and the excessive apoptosis of GCs induces the follicular atresia.
Yao Jiang +6 more
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KISS1 Suppresses Apoptosis and Stimulates the Synthesis of E2 in Porcine Ovarian Granulosa Cells
Animals, 2019 Previous studies have strongly recommended that KISS-1 metastasis suppressor (KISS1) plays an essential gatekeeper of the initiation of reproductive maturation in mammals.
Xiaoping Xin +8 more
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Serum kisspeptin levels mainly depend on ovarian expression of Kiss1 mRNA in female rats
Frontiers in Physiology, 2022 The hypothalamic kisspeptin/KISS1 receptor system is essential for puberty onset and reproductive development. Although serum kisspeptin might be associated with puberty, its levels, according to developmental stage, and its origin still remain unclear ...
Ahreum Kwon +7 more
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Estradiol modulates Kiss1 neuronal response to ghrelin [PDF]
American Journal of Physiology-Endocrinology and Metabolism, 2014 Ghrelin is a metabolic signal regulating energy homeostasis. Circulating ghrelin levels rise during starvation and fall after a meal, and therefore, ghrelin may function as a signal of negative energy balance. Ghrelin may also act as a modulator of reproductive physiology, as acute ghrelin administration suppresses gonadotropin ...
Renata, Frazao +7 more
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Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents
The Journal of Reproduction and Development, 2020 Kisspeptin, encoded by Kiss1, is essential for reproduction in mammals. Kiss1 expression is regulated by estrogen via histone acetylation in the Kiss1 promotor region.
Kei HORIHATA +4 more
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Upregulation of Kiss-1 and Gpr54 Genes Expression in Pituitary of Male Rats Following the Central Administration of Neuropeptide Y [PDF]
International Journal of Basic Science in Medicine, 2019 Introduction: The neuropeptide Y (NPY) in the neural circuits of the hypothalamus has a stimulating effect on reproductive activities in mammals. Kisspeptin (KiSS1) is a quintessential neurotransmitter in the reproductive axis which directly stimulates ...
Vahid Azizi +3 more
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Kiss1-PgrKO mice have impaired kisspeptin-mediated GnRH release.
, 2016 A. Serum LH before and after stimulation of kisspeptin neurons by exogenous administration of estradiol in 6-8-month-old ovariectomized WT and Kiss1-PgrKO mice (n = 3); a represent statistical difference between WT, and b represents statistical ...
Andrew Wolfe (703417) +9 more
core +1 more source
KISS1 in breast cancer progression and autophagy
Cancer and Metastasis Reviews, 2019 Tumor suppressors are cellular proteins typically expressed in normal (non-cancer) cells that not only regulate such cellular functions as proliferation, migration and adhesion, but can also be secreted into extracellular space and serve as biomarkers for pathological conditions or tumor progression.
Ilya V, Ulasov +4 more
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