Results 51 to 60 of about 7,724 (208)

Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse.

PLoS ONE, 2019
The normal function of the mammalian reproductive axis is strongly influenced by physiological, metabolic and environmental factors. Kisspeptin neuropeptides, encoded by the Kiss1 gene, are potent regulators of the mammalian reproductive axis by ...
Shel-Hwa Yeo, Victoria Kyle, Clemence Blouet, Susan Jones, William Henry Colledge   +4 more
doaj   +1 more source

The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil. [PDF]

PLoS ONE, 2017
The metastasis suppressor KISS1 is reported to be involved in the progression of several solid neoplasias, making it a promising molecular target for controlling their metastasis.
Alain Ibáñez de Opakua, Nekane Merino, Maider Villate, Tiago N Cordeiro, Georgina Ormaza, Marta Sánchez-Carbayo, Tammo Diercks, Pau Bernadó, Francisco J Blanco   +8 more
doaj   +1 more source

KISS1 in breast cancer progression and autophagy

Cancer and Metastasis Reviews, 2019
Tumor suppressors are cellular proteins typically expressed in normal (non-cancer) cells that not only regulate such cellular functions as proliferation, migration and adhesion, but can also be secreted into extracellular space and serve as biomarkers for pathological conditions or tumor progression.
Ilya V, Ulasov, Anton V, Borovjagin, Peter, Timashev, Massimo, Cristofanili, Danny R, Welch   +4 more
openaire   +3 more sources

Novel Insight into the Role of the Kiss1/GPR54 System in Energy Metabolism in Major Metabolic Organs

Cells, 2022
The Kiss1/GPR54 system is a multifunctional genetic system with an essential role in regulating energy balance and metabolic homeostasis. In the mammalian hypothalamus, two major populations of neurons, the rostral periventricular region of the third ...
Xuehan Li, Chunyu Liang, Yi Yan
doaj   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Reversibility and safety of KISS1 metastasis suppressor gene vaccine in immunocastration of ram lambs [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective The aim of this study was to investigate the reversibility and safety of KISS1 metastasis suppressor (KISS1) gene vaccine in immunocastration. Methods Six eight-week old ram lambs were randomly divided into vaccinated and control groups.
Yan-Guo Han, Gui-Qiong Liu, Xun-Ping Jiang, Xing-Long Xiang, Yong-Fu Huang, Bin Nie, Jia-Yu Zhao, Ijaz Nabeel, Birhanu Tesema   +8 more
doaj   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Molecular cloning and characterization of KISS1 promoter and effect of KISS1 gene mutations on litter size in the goat

Genetics and Molecular Research, 2013
Kisspeptins, the product of the KISS1 gene, play an essential role in the regulation of reproductive functions, acting primarily at the hypothalamic level of the gonadotropic axis. We detected polymorphisms of the goat KISS1 gene in 723 individuals from three goat breeds (Xinong Saanen, Guanzhong, and Boer) by DNA pooling, PCR-RFLP, and DNA sequencing ...
X P, An, P, Han, J X, Hou, H B, Zhao, Y, Yan, T, Ma, F, Fang, F X, Meng, Y X, Song, J G, Wang, B Y, Cao   +10 more
openaire   +2 more sources

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Estradiol Priming Potentiates the Kisspeptin-Induced Release of LH in Ovariectomized Cows

Animals, 2021
The present study examined whether priming with estradiol benzoate (EB) for 12 h increased both the peak and duration of LH release in response to kisspeptin (KISS1, KP) in cows.
Gustavo Guerino Macedo, Emiliana de Oliveira Santana Batista, Gustavo Martins Gomes dos Santos, Michael J. D’Occhio, Pietro Sampaio Baruselli   +4 more
doaj   +1 more source