Results 71 to 80 of about 8,886 (197)

The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma. [PDF]

, 2012
The objective of this study was to use the established xenograft model of human melanoma (C8161.9) to test a pharmacological approach to the effect of the metastasis suppressor KISS1. A KISS1 analog was used to inhibit the metastatic development of C8161.
Navenot, Jean-Marc, Fujii, Nobutaka, Peiper, Stephen C, Oishi, Shinya, Setsuda, Shohei, Evans, Barry   +5 more
core  

CHARACTERIZATION OF Kiss1 NEURONS USING TRANSGENIC MOUSE MODELS

, 2011
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism.
MARGATHO, L. O., ROVINSKY, S., GAUTRON, L., CRAVO, R. M., FRAZAO, R., BOOKOUT, A. L., DONATO JR., J., ZIGMAN, J. M., ELIAS, C. F., OSBORNE-LAWRENCE, S., ATKIN, S., LEE, C. E.   +11 more
core   +1 more source

Kiss1 and Kiss1 receptor expression in the rhesus monkey testis: a possible local regulator of testicular function

Open Life Sciences, 2013
Abstract
Tariq Amna, Shahab Muhammad, Clarke Iain, Pereira Alda, Smith Jeremy, Khan Saeed-ul-Hasan, Sultan Javeria, Javed Sehrish, Anwar Tayyaba   +8 more
openaire   +2 more sources

Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species

Frontiers in Endocrinology, 2018
Kisspeptin is a neuropeptide, encoded by kisspeptin 1 (KISS1)/Kiss1 gene, which primarily acts as the regulator of reproductive functions via its receptor, kisspeptin receptor (KissR) in vertebrates.
Satoshi Ogawa, Ishwar S. Parhar
doaj   +1 more source

Downregulation of TTF1 in the rat hypothalamic ARC or AVPV nucleus inhibits Kiss1 and GnRH expression, leading to puberty delay

Reproductive Biology and Endocrinology, 2021
Background TTF1 is a transcription factor that is expressed in the hypothalamus after birth and plays crucial roles in pubertal development. TTF1 may regulate the expression of the Kiss1 gene, which may drive puberty onset in the hypothalamic arcuate ...
Shaolian Zang, Xiaoqin Yin, Pin Li
doaj   +1 more source

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

VAX1 and SIX3 within Kisspeptin Neurons Regulate Kiss1 Gene Expression and the Reproductive Axis [PDF]

, 2021
Kisspeptin neurons, located in the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) of the hypothalamus, serve as critical regulators of reproduction, mediating puberty onset, ovulation, and pulsatile gonadotropin-releasing hormone ...
Lavalle, Shanna Newton
core  

Determination of KISS1, KISS1R and Kisspeptin in Fat Tissue of Normal Weight and Obese Humans and Correlations between Serum Kisspeptin and Leptin

Siriraj Medical Journal, 2017
Kisspeptin, a neuropeptide mainly expressed in the hypothalamus, has a major role in reproductive regulation. Previous studies showed that Kiss1 mRNA expression is also found in adipose tissue in rats.
Chantacha Sitticharoon, Vipada Boonpuan, Chalermchai Mitrpant, Malika Churintaraphan   +3 more
doaj  

KISS1 is secreted and processed into kisspeptins (KP) in multiple cell lines.

, 2014
A. (Top panel) Conditioned media collected from cultures of C8161.9, MelJuSo, MDA-MB-435, HeLa, COS7 and HEK293 cell lines which exogenously express KISS1.
Danny R. Welch (160661), Keke M. Pounds (508730), Tomoo Iwakuma (508731), Nabil G. Seidah (148050), Sitaram Harihar (508729)   +4 more
core   +1 more source

Maternal and infant gut microbiome

iMeta, Volume 5, Issue 4, August 2026.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source