Results 81 to 90 of about 8,330 (205)
Furin is required for the generation of KP from KISS1.
, 2014 A, C. RT-PCR and immunoblot data showing reduced mRNA and protein levels of furin, PCSK5 and PCSK7 in HEK293 cells transduced with shRNA directed against each PC either individually or in combination.
Danny R. Welch (160661) +4 more
core +1 more source
Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse [PDF]
Endocrinology, 2005 The Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion. We examined whether estradiol (E2) regulates KiSS-1 in the forebrain of the female mouse by comparing KiSS-1 mRNA expression among groups of ovary-intact ...
Smith, Jeremy T. +4 more
openaire +2 more sources
Acta Physiologica, Volume 242, Issue 4, April 2026.ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos +9 more
wiley +1 more source
Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.Abstract The arcuate nucleus kisspeptin (ARNKISS) neurons intermittently synchronize their activity to operate as the GnRH pulse generator and drive pulsatile reproductive hormone secretion in mammals. Although ARNKISS neurons are known to receive various GABAergic inputs, the effects of GABAA and GABAB receptor modulation on their ability to ...
Toby Eddleston +2 more
wiley +1 more source
PGR does not regulate Kiss1 gene expression.
, 2016 Kiss1 mRNA expression level in 6-month-old WT (n = 9) and Kiss1-PgrKO (n = 4) mice.
Andrew Wolfe (703417) +9 more
core +1 more source
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, Volume 13, Issue 17, 23 March 2026.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
CRE-dependent PRV-GFP activation in Kiss1 neurons.
, 2019 Stereotaxic delivery of the PRVINTRO virus into the arcuate (ARC) region of mice was associated with GFP expression only in Kiss1-CRE mice. PRVINTRO driven GFP expression (arrowed) at 24 h after delivery was restricted to Kiss1 neurons (A) but at 48 h ...
Clemence Blouet (6519428) +4 more
core +1 more source
KISS1 in metastatic cancer research and treatment: potential and paradoxes
Cancer and Metastasis Reviews, 2020 The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm regarding KISS1 has cumulated in clinical trials in multiple fields related to reproduction and metabolism. But its cancer therapeutic space is unsettled. This
Thuc Ly, Sitaram Harihar, Danny R. Welch
openaire +3 more sources
Animal Models and Experimental Medicine, Volume 9, Issue 3, Page 453-461, March 2026.We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong +5 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source