Results 1 to 10 of about 3,707 (112)

GPR54 regulates non-small cell lung cancer development via dopa decarboxylase [PDF]

Signal Transduction and Targeted Therapy
Non-small cell lung cancer (NSCLC), the most common type of lung cancer, is a leading cause of cancer death. G protein-coupled receptor 54 (GPR54) plays a role in cancer development by interacting with its endogenous ligand kisspeptin encoded by the ...
Hyun-Ha Hwang, Seo Yeon Lee, Chanhee Lee, Jeong Yoon Lee, Seong-Gyu Ko, Sung-Gook Cho   +5 more
doaj   +2 more sources

Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts [PDF]

Toxins
Zearalenone (ZEA) is a potent estrogenic mycotoxin known to disrupt reproductive functions, but its precise central neuroendocrine mechanisms remain unclear.
Zixue Yuan, Min Zhou, Yue Luan, Lei Kong, Weiren Yang, Shuzhen Jiang   +5 more
doaj   +2 more sources

Gpr54 deletion accelerates hair cycle and hair regeneration [PDF]

EMBO Reports
GPR54, or KiSS-1R (Kisspeptin receptor), is key in puberty initiation and tumor metastasis prevention, but its role on hair follicles remains unclear.
Weili Xia, Caibing Wang, Biao Guo, Zexin Tang, Xiyun Ye, Yongyan Dang   +5 more
doaj   +2 more sources

Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src [PDF]

Nature Communications
Osteoclasts are over-activated as we age, which results in bone loss. Src deficiency in mice leads to severe osteopetrosis due to a functional defect in osteoclasts, indicating that Src function is essential in osteoclasts.
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao   +31 more
doaj   +2 more sources

Obesity and cervical intraepithelial neoplasia: regulation of mitochondrial energy metabolism via the Kisspeptin/GPR54 signaling pathway [PDF]

Cancer & Metabolism
Background Obesity exacerbates the severity of cervical intraepithelial neoplasia (CIN), potentially through metabolic alterations. This study investigates how the Kisspeptin/GPR54 signaling pathway mediates mitochondrial energy metabolism in obesity ...
Jiajia Pan, Yuanyuan Chen, Yan Ye, Peipei Li, Feifei Ni, Haizhen He   +5 more
doaj   +2 more sources

Involvement of the kisspeptin system in regulation of sexual behaviors in medaka [PDF]

iScience
Summary: In mammals, kisspeptin (Kiss1) neurons are generally considered as a sex steroid-dependent key regulator of hypothalamic-pituitary-gonadal (HPG) axis.
Mikoto Nakajo, Shinji Kanda, Yoshitaka Oka   +2 more
doaj   +2 more sources

Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway [PDF]

Journal of Neuroinflammation
Background Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions. While neuroendocrine-immune system dysfunction plays a crucial role in the development of autoimmune diseases, its involvement in MG remains largely unexplored.
Dan Lu, Linqi Liu, Wenjun Que, Rui Fan, Pingyang Ke, Jing Dong, Yaoqi Gan, Fei Xiao   +7 more
doaj   +2 more sources

The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology

Genes and Diseases, 2022
KiSS-1, first identified as an anti-metastasis gene in melanoma, encodes C-terminally amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10.
Nisha Zhu, Mengxiang Zhao, Yuxian Song, Liang Ding, Yanhong Ni   +4 more
doaj   +1 more source

GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner. [PDF]

PLoS ONE, 2010
G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation.
Jacob M Szereszewski, Macarena Pampillo, Maryse R Ahow, Stefan Offermanns, Moshmi Bhattacharya, Andy V Babwah   +5 more
doaj   +1 more source

The effect of high-fat diet and exercise on KISS-1/GPR54 expression in testis of growing rats

Nutrition & Metabolism, 2021
Purpose To find the expression of KISS-1 and G protein-coupled receptor 54 in rats testis from PND 21st to 56th. Method 128 three-week-old weaned rats underwent high-fat diet and exercise (60–70% VO2max, 1 h/day, 5 days/week) intervention and were ...
Junpeng Feng, Rui Xu, Yafei Li, Qishu Zhou, Ge Song, Yimin Deng, Yi Yan   +6 more
doaj   +1 more source