Results 1 to 10 of about 3,648 (171)

Gpr54 deletion accelerates hair cycle and hair regeneration [PDF]

EMBO Reports
GPR54, or KiSS-1R (Kisspeptin receptor), is key in puberty initiation and tumor metastasis prevention, but its role on hair follicles remains unclear.
Weili Xia, Caibing Wang, Biao Guo, Zexin Tang, Xiyun Ye, Yongyan Dang   +5 more
doaj   +4 more sources

GPR54 regulates non-small cell lung cancer development via dopa decarboxylase [PDF]

Signal Transduction and Targeted Therapy
Non-small cell lung cancer (NSCLC), the most common type of lung cancer, is a leading cause of cancer death. G protein-coupled receptor 54 (GPR54) plays a role in cancer development by interacting with its endogenous ligand kisspeptin encoded by the ...
Hyun-Ha Hwang, Seo Yeon Lee, Chanhee Lee, Jeong Yoon Lee, Seong-Gyu Ko, Sung-Gook Cho   +5 more
doaj   +2 more sources

GPR54 and kisspeptin in reproduction [PDF]

Human Reproduction Update, 2006
Abstract Kisspeptins, the peptide products of the KiSS-1 gene, were identified in 2001 as natural ligands of the previously orphan G protein-coupled receptor, GPR54. They include, among others, metastin and kisspeptin-10. The known biological functions of kisspeptins were initially restricted to their ability to suppress tumour ...
Manuel Tena-Sempere, Tena-Sempere Manuel   +1 more
exaly   +3 more sources

Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts [PDF]

Toxins
Zearalenone (ZEA) is a potent estrogenic mycotoxin known to disrupt reproductive functions, but its precise central neuroendocrine mechanisms remain unclear.
Zixue Yuan, Min Zhou, Yue Luan, Lei Kong, Weiren Yang, Shuzhen Jiang   +5 more
doaj   +2 more sources

Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1. [PDF]

CNS Neurosci Ther
The Kisspeptin‐10 (KP‐10)/GPR54 signaling pathway is dysregulated in both individuals with cerebral aneurysms and experimentally induced mice. KP‐10 administration prevents CA formation in wild type but not GPR54 KO mice, highlighting the crucial role of GPR54 in mediating KP‐10's protective effects. KP‐10 inhibits the expression of MMP‐9 and VEGF‐A in
Yu H, Xie M, Liufu X, Xu Y, Chen L.
europepmc   +2 more sources

Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis. [PDF]

Adv Biol (Weinh)
This study introduces and investigates different‐sex gonad transplants in a mouse model of gender‐affirming hormone therapy. Ovaries and testes implanted into gonadectomized adults exhibit gametogenesis and steroidogenesis independent of the sex of the host.
Pfau DR, Rionda MA, Cho E, Clark JG, Kruger RE, Chan-Sui RK, Padmanabhan V, Moravek MB, Shikanov A.   +8 more
europepmc   +2 more sources

Design and synthesis of fluorescent probes for GPR54 [PDF]

Bioorganic and Medicinal Chemistry, 2014
Kisspeptins are neuropeptides that induce the secretion of gonadotropin-releasing hormone via the activation of the cognate receptor, G-protein coupled receptor 54 (GPR54). The kisspeptin-GPR54 axis is associated with the onset of puberty and the maintenance of the reproductive system.
Nahoko Ieda, Nobutaka Fujii, Shinya Oishi   +2 more
exaly   +4 more sources

New Insights in Bovine Follicular Cysts. [PDF]

Reprod Domest Anim
ABSTRACT The aim of the present study was to understand the involved factors in follicular cysts in dairy cows. The study consisted of an in vivo and in vitro approach. The in vivo part, hormonal evaluation (Kisspeptin‐10 [Kp‐10], Gonadotropin inhibiting hormone [GnIH], Luteinizing hormone [LH], Oestrogens [E2] and cortisol) was performed in sera of ...
Carbonari A, Martino NA, Burgio M, Cicirelli V, Frattina L, Dell'Aquila ME, Rizzo A.   +6 more
europepmc   +2 more sources

Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src [PDF]

Nature Communications
Osteoclasts are over-activated as we age, which results in bone loss. Src deficiency in mice leads to severe osteopetrosis due to a functional defect in osteoclasts, indicating that Src function is essential in osteoclasts.
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao   +31 more
doaj   +2 more sources

Obesity and cervical intraepithelial neoplasia: regulation of mitochondrial energy metabolism via the Kisspeptin/GPR54 signaling pathway [PDF]

Cancer & Metabolism
Background Obesity exacerbates the severity of cervical intraepithelial neoplasia (CIN), potentially through metabolic alterations. This study investigates how the Kisspeptin/GPR54 signaling pathway mediates mitochondrial energy metabolism in obesity ...
Jiajia Pan, Yuanyuan Chen, Yan Ye, Peipei Li, Feifei Ni, Haizhen He   +5 more
doaj   +2 more sources