Results 31 to 40 of about 4,181 (199)
The role of kisspeptin and GPR54 in the hippocampus
Peptides, 2009 The granule cells of the dentate gyrus form the input stage of the hippocampal trisynaptic circuit and their function is strongly influenced by peptidergic systems. GPR54 is highly and discretely expressed in these cells. We have found that activation of GPR54 with kisspeptin-10 causes a rapid and large increase in the amplitude of excitatory synaptic ...
Amy C. Arai +2 more
openaire +3 more sources
Upregulation of Kiss-1 and Gpr54 Genes Expression in Pituitary of Male Rats Following the Central Administration of Neuropeptide Y [PDF]
International Journal of Basic Science in Medicine, 2019 Introduction: The neuropeptide Y (NPY) in the neural circuits of the hypothalamus has a stimulating effect on reproductive activities in mammals. Kisspeptin (KiSS1) is a quintessential neurotransmitter in the reproductive axis which directly stimulates ...
Vahid Azizi +3 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The purpose of this study was to explore the effect of the traditional Chinese medicine Fuyou formula on precocious puberty (PP). The Fy formula may exert an effect in female rats with PP and GT-7 cells through the GPR54/GnRH signaling pathway.
Guo-liang Bai +13 more
doaj +1 more source
Prognostic value of metastin expression in human pancreatic cancer
Journal of Experimental & Clinical Cancer Research, 2009 Background KiSS-1 was identified as a metastasis-suppressing gene in melanoma cells. The KiSS-1 gene product (metastin) was isolated from human placenta as the ligand of GPR54, a G-protein-coupled receptor.
Kawaguchi Yoshiya +11 more
doaj +1 more source
Expression and function of kisspeptin during mouse decidualization. [PDF]
PLoS ONE, 2014 BACKGROUND: Plasma kisspeptin levels dramatically increased during the first trimester of human pregnancy, which is similar to pregnancy specific glycoprotein-human chorionic gonadotropin.
Peng Zhang +8 more
doaj +1 more source
Expression analysis of DIO2, EYA3, KISS1 and GPR54 genes in year-round estrous and seasonally estrous rams [PDF]
Archives Animal Breeding, 2020 The expression characteristics of the hypothalamic–pituitary–gonadal (HPG) axis-related candidate genes, DIO2, EYA3, KISS1 and GPR54, were analyzed in year-round estrous rams (small-tail Han sheep, STH) and seasonally estrous rams (Sunite sheep, SNT ...
Q. Xia +4 more
doaj +1 more source
Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction [PDF]
Journal of Neuroendocrinology, 2008 In order to find novel modulators of gonadotrophin‐releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G‐protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function ...
S B, Seminara, W F, Crowley
openaire +2 more sources
Elevated expression of KiSS-1 in placenta of Chinese women with early-onset preeclampsia. [PDF]
PLoS ONE, 2012 Preeclampsia (PE) is a heterogeneous syndrome affecting 2% to 8% of all pregnancies and is the world's leading cause of fetal and maternal morbidity and mortality. In many cases of PE, shallow trophoblast invasion results in inappropriate maternal spiral
Chong Qiao +4 more
doaj +1 more source
Novel Insight into the Role of the Kiss1/GPR54 System in Energy Metabolism in Major Metabolic Organs
Cells, 2022 The Kiss1/GPR54 system is a multifunctional genetic system with an essential role in regulating energy balance and metabolic homeostasis. In the mammalian hypothalamus, two major populations of neurons, the rostral periventricular region of the third ...
Xuehan Li, Chunyu Liang, Yi Yan
doaj +1 more source
The Effects of 5-Hydroxytryptamine and Interaction With Kisspeptin in Controlling Ghrelin and Adiponectin Secretion [PDF]
International Journal of Basic Science in Medicine, 2022 Introduction: 5-Hydroxytryptamine (5HT) and kisspeptin are satiety factors, and ghrelin and adiponectin are orexigenic peptides. In this study, the mediating role of 5HT in the effects of GPR54 receptor blocking on ghrelin and adiponectin secretion was ...
Maryam Kamvar +4 more
doaj +1 more source