Results 51 to 60 of about 4,400 (198)
针刺研究, 2019 Objective To observe the effect of warm needle moxibustion(WNM),mild moxibustion and electroacupuncture(EA)of"Shenshu"(BL23)and"Guanyuan"(CV4)on serum gonadal hormone levels and related gene expression in the hypothalamus and testis in aged rats,so as to
MA Lin +6 more
doaj +2 more sources
Novel genetic polymorphisms in caprine GPR54 gene associated with reproductive functions
Indian Journal of Animal Sciences, 2014 The objective of this study was to characterize caprine GPR54 gene, a key mediator of molecular mechanism of reproduction (puberty and prolificacy) in mammals.
A MAITRA +3 more
doaj +1 more source
, 2013 The results for gpr54-1 mRNA signals (A, D, G) and gpr54-2 mRNA signals (C, F, I) show that the gpr54-1- and gpr54-2-expressing neurons are localized in the POA surrounding the GnRH1 neurons (A–C), but not in the midbrain tegmentum surrounding the GnRH2 ...
Yasuhisa Akazome (407147) +4 more
core +1 more source
Expressions of Kisspeptin System and Ki‐67 in the Reproductive Tissues of Cyclic Bitches
Reproduction in Domestic Animals, Volume 61, Issue 4, April 2026.ABSTRACT Kisspeptin is a peptide that plays a pivotal role in the central regulation of gonadotropins. It is regarded as a key regulator of reproductive processes, including follicular and luteal development and endometrial remodelling. The objective of this study was to investigate the expression of KISS1, its receptor KISS1R and the proliferation ...
Özgecan Korkmaz Ağaoğlu +4 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 9, Issue 3, Page 453-461, March 2026.We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong +5 more
wiley +1 more source
Frontiers in Neuroscience, 2018 The kisspeptin/GPR54 system plays a crucial role in the regulation of the reproductive axis in vertebrates. Male pregnancy and ovoviviparity are special reproductive phenomena among vertebrates.
Huixian Zhang +6 more
doaj +1 more source
Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. [PDF]
PLoS ONE, 2014 The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration.
Víctor A Francis +4 more
doaj +1 more source
KISS1 and Its G Protein-Coupled Receptor (GPR54) in Cancer Progression and Metastasis [PDF]
, 2010 Activation of G-protein coupled receptor 54 (GPR54) signaling generated by kisspeptins (endogenous GPR54 ligands encoded by KISS1 gene) has been known to regulate puberty and to suppress cancer metastasis. However, an endogenous GPR54 signaling in cancer
Cho, Sunggook Gook
core
GPR54 (Kiss1R) immunostaining in the Placenta.
, 2013 Fig. 2 (a–c) demonstrate GPR54 immunohistochemistry with individual villous cytotrophoblast cell staining for GPR 54 (red) in the placental villus (pv) (Fig. 2a). Fig. 2b shows GPR54 (red) immunostaining of villous cytotrophoblasts (vCT), cytotrophoblast
Robert Millar (413075) +3 more
core +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.The study identified a novel SEMA3A exons 6–9 deletion variant in Kallmann syndrome that impairs GnRH neuronal migration and alters cell migration, gonad development, and synaptic pathways. The study expands mutation spectrum and offers mechanistic insights for clinical diagnosis of Kallmann syndrome.
Shaolian Zang +4 more
wiley +1 more source