Results 51 to 60 of about 4,181 (199)
Animal Models and Experimental Medicine, Volume 9, Issue 3, Page 453-461, March 2026.We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong +5 more
wiley +1 more source
Frontiers in Neuroscience, 2018 The kisspeptin/GPR54 system plays a crucial role in the regulation of the reproductive axis in vertebrates. Male pregnancy and ovoviviparity are special reproductive phenomena among vertebrates.
Huixian Zhang +6 more
doaj +1 more source
Chapter 2 Human Diseases Associated with GPR54 Mutations
, 2009 G protein‐coupled receptor 54 (GPR54) was first described as an orphan receptor in the rat brain one decade ago. At that time, all we knew about this receptor was that it had a high homology with other G protein‐coupled receptors, like galanin receptors.
Suzy Bianco +10 more
core +1 more source
Kisspeptin regulation of genes involved in cell invasion and angiogenesis in first trimester human trophoblast cells. [PDF]
PLoS ONE, 2014 The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration.
Víctor A Francis +4 more
doaj +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.The study identified a novel SEMA3A exons 6–9 deletion variant in Kallmann syndrome that impairs GnRH neuronal migration and alters cell migration, gonad development, and synaptic pathways. The study expands mutation spectrum and offers mechanistic insights for clinical diagnosis of Kallmann syndrome.
Shaolian Zang +4 more
wiley +1 more source
Hyperalgesic activity of kisspeptin in mice
Molecular Pain, 2011 Background Kisspeptin is a neuropeptide known for its role in the hypothalamic regulation of the reproductive axis. Following the recent description of kisspeptin and its 7-TM receptor, GPR54, in the dorsal root ganglia and dorsal horns of the spinal ...
Spampinato Simona +9 more
doaj +1 more source
Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling [PDF]
Reproduction, 2006 Abstract The Kiss1 gene codes for a family of peptides that act as endogenous ligands for the G protein-coupled receptor GPR54. Spontaneous mutations or targeted deletions of GPR54 in man and mice produce hypogonadotropic hypogonadism and infertility.
Jeremy T, Smith +2 more
openaire +2 more sources
Obesity Reviews, Volume 27, Issue 1, Page 1-21, January 2026.ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic–pituitary–ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The risk of complications during pregnancy, such as gestational diabetes mellitus (GDM) and preeclampsia (PE)
Shaohua Zhang +5 more
wiley +1 more source
International Journal of Genomics, Volume 2026, Issue 1, 2026.Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy. Here, we conducted a comprehensive investigation of KISS1 across various cancers, with a specific focus on breast cancer, using TCGA and GTEx datasets.
Chunbiao Wu +8 more
wiley +1 more source
Functional characterization of endogenous GPR54 mutants
The FASEB Journal, 2007 Increasing evidence suggests that the G‐protein coupled receptor GPR54, along with its ligand kisspeptin, play a pivotal role in the signaling cascade that initiates puberty. Accordingly, a small percentage of cases of isolated hypogonadotrophic hypogonadism (IHH) are caused by homozygous recessive mutations in human GPR54.
Jennifer L Wacker +2 more
openaire +1 more source