Results 71 to 80 of about 4,181 (199)

Warm needle moxibustion,mild moxibustion and electroacupuncture interventions have an antiaging effect possibly by regulating hypothalamus-pituitary-testis axis in aged male rats

针刺研究, 2019
Objective To observe the effect of warm needle moxibustion(WNM),mild moxibustion and electroacupuncture(EA)of"Shenshu"(BL23)and"Guanyuan"(CV4)on serum gonadal hormone levels and related gene expression in the hypothalamus and testis in aged rats,so as to
MA Lin, LI Xue-zhi, YAO Tai-wan, WU Jia-peng, XI Xiao-fang, FU Yan, LIU Jia   +6 more
doaj  

Potent Vasoconstrictor Kisspeptin‐10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundKisspeptin‐10 (KP‐10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre‐eclampsia.
Kengo Sato, Remina Shirai, Mina Hontani, Rina Shinooka, Akinori Hasegawa, Tomoki Kichise, Tomoyuki Yamashita, Hayami Yoshizawa, Rena Watanabe, Taka‐aki Matsuyama, Hatsue Ishibashi‐Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe   +14 more
doaj   +1 more source

Kisspeptins and GPR54—The new biology of the mammalian GnRH axis [PDF]

Cell Metabolism, 2005
Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis.
openaire   +2 more sources

An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

Advanced Healthcare Materials, Volume 13, Issue 29, November 22, 2024.
The analgesics currently employed in tumor are immunosuppressive. A painless administration of Esketamine combined with Cisplatin (DDP)co‐loaded in a thermo‐sensitive injectable hydrogel (PDEH) is designed to improve the immunosuppressive tumor microenvironment (TME) by activating Dendritic Cells (DCs), interferon‐γ (IFN‐γ) cells and inhibiting ...
Xiali Yin, Yaohua Ke, Ying Liang, Shuxian Zhang, Ziqi Chen, Lixia Yu, Ming Jiang, Qin Liu, Xiaoping Gu   +8 more
wiley   +1 more source

Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system

Reproductive Biology and Endocrinology, 2019
Background Excessive gestational weight gain (GWG), which is associated with adverse long-term effects on the health of the offspring, has become a major clinical problem.
Zhiyang Zhou, Qi Lin, Xinxin Xu, Gaby Sukma Illahi, Chenle Dong, Xueqing Wu   +5 more
doaj   +1 more source

Phoenixin knockout mice show no impairment in fertility or differences in metabolic response to a high‐fat diet, but exhibit behavioral differences in an open field test

Journal of Neuroendocrinology, Volume 36, Issue 10, October 2024.
Phoenixin (PNX) is a peptide that had been linked to the control of reproduction and energy homeostasis but the homozygous knockout (KO) of PNX did not impact fertility or the amount of weight gained on a high fat diet, possibly due to compensation. PNX has also been demonstrated to have anti‐inflammatory effects in vivo and in vitro but we found that ...
Emma K. McIlwraith, Neruja Loganathan, Kimberly W. Y. Mak, Wenyuan He, Denise D. Belsham   +4 more
wiley   +1 more source

Κλινική και μοριακή μελέτη παιδιών με διαταραχές ενήβωσης (Έλεγχος σχετικών γονιδιακών επιτόπων - γονίδιο GPR54) [PDF]

, 2014
Η έναρξη της εφηβείας είναι ένα σύνθετο φαινόμενο και οι μηχανισμοί που εμπλέκονται σε αυτήν παραμένουν εν πολλοίς άγνωστοι. Τα νευροπεπτίδια Kisspeptin και Neurokinin Β παίζουν κεντρικό ρόλο στην ενεργοποίηση των GnRH νευρώνων.
Λέκα-Εμίρη Σοφία
core  

A career in numbers: A citation network analysis of the work of RP Millar and his contribution to GnRH research

Journal of Neuroendocrinology, Volume 36, Issue 10, October 2024.
Here, we use citation network analysis in a novel manner to identify the particular topics to which RP Millar's papers have made a particular contribution. This analysis shows that it makes no sense to conceive of the citation impact of an author in isolation; it depends on the existence of a receptive community that is alert to the potential utility ...
Rhodri I. Leng, Gareth Leng
wiley   +1 more source

Antiproliferative effects of kisspeptin-10 depend on artificial GPR54 (KISS1R) expression levels

, 2013
Kisspeptins are peptides derived from the metastasis suppressor gene KISS1 interacting with GPR54 as their corresponding receptor. The KISS1/GPR54 system is one regulator of cellular motility mechanisms leading to decreased migration and invasion.
Ziegler, Elke, Olbrich, Teresa, Emons, Guenter, Gruendker, Carsten   +3 more
core   +1 more source

Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?

Cellular Physiology and Biochemistry, 2018
Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and ...
Camila M. Trevisan, Erik Montagna, Renato de Oliveira, Denise M. Christofolini, Caio P. Barbosa, Keith A. Crandall, Bianca  Bianco   +6 more
doaj   +1 more source