Results 91 to 100 of about 4,400 (198)
Frontiers in Endocrinology, 2013 The prominent role of the G protein coupled receptor GPR54 and its peptide ligand kisspeptin in the progression of puberty has been extensively documented in many mammalian species including humans. Kisspeptins are very potent GnRH secretagogues produced
Isabelle eFranceschini +1 more
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SAR and QSAR Studies on the N-Terminally Acylated Pentapeptide Agonists for GPR54
, 2016 Kisspeptins (KPs) play important roles in the regulation of physiological and pathological states through activation of the cognate receptor GPR54. Our previous studies to downsize KP agonists to the essential GPR54 pharmacophore identified peptides 1−3 ...
Hiroaki Ohno (1457971) +8 more
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Does kisspeptin signalling have a role in the testes?
Frontiers in Endocrinology, 2013 Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that regulate the mammalian reproductive axis by a central action in the hypothalamus to stimulate GnRH release. Kisspeptins and their receptor (Gpr54 also called Kiss1r) are
Mei eHua +4 more
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, 2013 Medaka gpr54-1 (A, C) or gpr54-2 (B, D) cDNA was transfected to COS-7 cells with SRE-luc or CRE-luc vector. Various concentrations of medaka Kiss1 and Kiss2 were applied to the culture medium, and the luciferase activity was measured.
Yasuhisa Akazome (407147) +4 more
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Supplementary Movie 1 from GPR54 Is a Target for Suppression of Metastasis in Endometrial Cancer
, 2011 Supplementary Movie 1 from GPR54 Is a Target for Suppression of Metastasis in Endometrial ...
Hyun Sook Kang (14917305) +11 more
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The functional study of KiSS-1 and GPR54 expression in mouse Leydig cell
, 2010 發身(puberty)是動物啟動生殖周期的發軔，並進入成熟生理的變化；不論雄性或雌性動物達發身年齡後，體內生殖內分泌開始運轉，此時下視丘會分泌促性腺激素釋放激素(Gonadotropin release hormone, GnRH)，進而刺激腦垂腺之排卵素(LH)、濾泡激素(FSH)等激性腺素分泌，使性腺發育成熟。此為現今熟知能調控動物生殖生理機制的HPG軸(Hypothalamic-pituitary-gonad axis) 。近年來發現，人類和小鼠下視丘上GPR54 (G protein ...
曾泰祥, Tseng, Tai-Hsiang
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GPR54 activates ERK1/2 in a β-arrestin-dependent manner.
, 2013 Representative autoradiograph (A) and densitometric analysis (B) showing the expression of total and activated ERK1/2 in GPR54 overexpressing β-Arr1/2 double KO (β-Arr1/2 KO) and corresponding wild type parental (WT2) MEFs following stimulation with 100 ...
Andy V. Babwah (215961) +5 more
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, 2013 Kisspeptins, acting via GPR54, are new players in the control of reproductive axis. They have the ability to communicate with GnRH neurons sending environmental, metabolic, and gonadal signals, with the induction of GnRH and LH secretion as final ...
PIERANTONI, Riccardo +4 more
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Molecular co-evolution of kisspeptins and GPR54s
Frontiers in Endocrinology, 2011 Jae Young Seong, Kazuyoshi Tsutsui, and Hubert Vaudry Laboratory of G Protein-Coupled Receptors, Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea Department of Biology, Waseda University, Tokyo 162-8480, Japan INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research ...
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Κλινική και μοριακή μελέτη παιδιών με διαταραχές ενήβωσης (Έλεγχος σχετικών γονιδιακών επιτόπων - γονίδιο GPR54) [PDF]
, 2014 Η έναρξη της εφηβείας είναι ένα σύνθετο φαινόμενο και οι μηχανισμοί που εμπλέκονται σε αυτήν παραμένουν εν πολλοίς άγνωστοι. Τα νευροπεπτίδια Kisspeptin και Neurokinin Β παίζουν κεντρικό ρόλο στην ενεργοποίηση των GnRH νευρώνων.
Λέκα-Εμίρη Σοφία
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