Results 91 to 100 of about 4,181 (199)
The Novel Role of Kisspeptin and GPR54 in Mice Reproduction
, 2013 近年研究指出Kisspeptin與其受體GPR54在動物的生殖生理調控扮演重要的角色。Kisspeptin為Kiss1基因的蛋白質產物，其生殖生理之功能主在刺激GnRH神經元興奮進而調控下游的下視丘-腦垂腺-性腺軸及其所引發的相關生理調控。目前已有報告提出Kiss-1與Gpr54基因在動物多種器官組織均有表現，然而其所調控的生理功能則尚未完全被瞭解。因此，本研究將探討kisspeptin與GPR54在小鼠睪丸與卵巢組織之表現性狀及其可能扮演之功能。 本研究以成年ICR小鼠做為實驗動物 ...
許孟傑, Hsu, Meng-Chieh
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Molecular co-evolution of kisspeptins and GPR54s
Frontiers in Endocrinology, 2011 Jae Young Seong, Kazuyoshi Tsutsui, and Hubert Vaudry Laboratory of G Protein-Coupled Receptors, Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea Department of Biology, Waseda University, Tokyo 162-8480, Japan INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research ...
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Expression of GPR54 in mouse uterus during early pregnancy.
, 2014 (A) Levels of GPR54 mRNA expression in the uterus during early pregnancy via quantitative PCR analysis. (B) Immunostaining of GPR54 protein in mouse uterus on days 1, 4, 5, 6, 7, and 8 of pregnancy. Upper and middle panel show original magnification ×100.
Teng Zong (564795) +8 more
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Elucidating the molecular mechanisms controlling GPR54 expression
The FASEB Journal, 2009 Increasing evidence suggests that the G‐protein coupled receptor GPR54, together with its endogenous peptide ligand kisspeptin (KP), play pivotal roles in the initiation of puberty and reproduction. For example, previous studies report blood plasma concentration of kisspeptin increases by ~9000 fold during ...
Mia C. DeFino +5 more
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Kisspeptin and Cancer: Molecular Interaction, Biological Functions, and Future Perspectives
Frontiers in Endocrinology, 2018 Cancer disease is the second leading cause of death in the world and one of the main fields of medical research. Although there is now a greater understanding of biological mechanisms of uncontrolled cell growth, invasiveness and metastasization, the ...
Vincenza Ciaramella +3 more
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Studying the reproduction-biological effect of the GPR54 receptor gene in sheep
, 2007 One of the main economical problems of sheep breeding is that continual production is not possible due to the seasonality of animals. Today, genes, mutations that may develop aseasonality in sheep are extensively researched in order to make the ...
Jávor, András +2 more
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Case Reports in Pediatrics, 2019 KISS1R (GPR54) mutations have been reported in several patients with congenital normosmic idiopathic hypogonadotropic hypogonadism (nIHH). We aim to describe in detail nIHH patients with KISS1R (GPR54) mutations belonging to one related extended family ...
Ahmad J. Alzahrani +3 more
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, 2018 Kisspeptin-10 (KP-10) acts as a tumor metastasis suppressor via its receptor, G-protein-coupled receptor 54 (GPR54). The KP-10-GPR54 system plays an important role in embryonic kidney development.
Kyeong-Min Kim +3 more
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Absence of GPR54 and TACR3 mutations in sporadic cases of idiopathic central precocious puberty
, 2014 Background/Aims: Kisspeptin (KISS1)/GPR54 (KISSR) signaling complex and neurokinin B (NKB)/NKB receptor (TACR3) signaling have been proposed as an integral part of the network coordinating GnRH release.
Louizou, E. +5 more
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DIG-labelled in situ hybridization of gpr54-1 shows localization of gpr54-1 mRNA positive cells.
, 2013 gpr54-1 mRNA positive neurons are localized in POp, POm (A), Vd/Vs/Vp (not shown), and habenula (Hb; B). Scale bars: 50 µm.
Yasuhisa Akazome (407147) +4 more
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