Results 81 to 90 of about 4,181 (199)
Annals of the New York Academy of Sciences, Volume 1540, Issue 1, Page 47-60, October 2024.The neuropeptide kisspeptin is a critical endogenous activator of the reproductive system. Notably, both kisspeptin and its receptor are expressed in the key bone cells, osteoblasts, and osteoclasts, suggesting direct bone effects. In this review, we examine the evidence derived from in vitro experiments through to in vivo and clinical studies ...
Edouard G. Mills +3 more
wiley +1 more source
SAR and QSAR Studies on the N-Terminally Acylated Pentapeptide Agonists for GPR54
, 2016 Kisspeptins (KPs) play important roles in the regulation of physiological and pathological states through activation of the cognate receptor GPR54. Our previous studies to downsize KP agonists to the essential GPR54 pharmacophore identified peptides 1−3 ...
Hiroaki Ohno (1457971) +8 more
core +1 more source
Kisspeptin Activates Ankrd 26 Gene Expression in Migrating Embryonic GnRH Neurons
Frontiers in Endocrinology, 2016 Kisspeptin, a newly discovered neuropeptide regulates gonadotropin-releasing hormone (GnRH). Kisspeptins are a large RF-amide family of peptides. The kisspeptin coded by kiss1 gene is a 145-amino acid- protein that is cleaved to C-terminal peptide ...
Tomoko eSoga +3 more
doaj +1 more source
Construction of an intranasal drug delivery system with hypothalamus‐targeting nanoparticles
SusMat, Volume 4, Issue 4, August 2024.A multifunctional nanocarrier system (S@ANP) was constructed to directly target the hypothalamic neurokinin receptor 3 (NK3R) via an intranasal delivery strategy. Under the guidance of a modified NKA peptide (NKA‐C), composite S@ANP could bypass the blood‒brain barrier and penetrate hypothalamic cells with a substantial loading capacity upon intranasal
Qianru Rao +7 more
wiley +1 more source
Helvetica Chimica Acta, Volume 107, Issue 4, April 2024.Abstract The RFamide family of peptides represents an important class of GPCR ligand neuropeptides covering a wide range of biological functions. While many analogues of the highly conserved C‐terminal RFamide motif within this peptide class have been synthesized and their functional significance elucidated, additional exploration of the structure ...
Gemma Mudd +5 more
wiley +1 more source
GPR54 activates ERK1/2 in a β-arrestin-dependent manner.
, 2013 Representative autoradiograph (A) and densitometric analysis (B) showing the expression of total and activated ERK1/2 in GPR54 overexpressing β-Arr1/2 double KO (β-Arr1/2 KO) and corresponding wild type parental (WT2) MEFs following stimulation with 100 ...
Andy V. Babwah (215961) +5 more
core +1 more source
Frontiers in Endocrinology, 2013 The prominent role of the G protein coupled receptor GPR54 and its peptide ligand kisspeptin in the progression of puberty has been extensively documented in many mammalian species including humans. Kisspeptins are very potent GnRH secretagogues produced
Isabelle eFranceschini +1 more
doaj +1 more source
, 2013 Kisspeptins, acting via GPR54, are new players in the control of reproductive axis. They have the ability to communicate with GnRH neurons sending environmental, metabolic, and gonadal signals, with the induction of GnRH and LH secretion as final ...
PIERANTONI, Riccardo +4 more
core +1 more source
The kisspeptin and GPR54 ligand-receptor pair in autocrine and endocrine signalling in cancer
, 2009 Kisspeptins and their receptor, GPR54, mediate sex hormone release through stimulation of the hypothalamic-pituitary-gonadal axis and have been implicated as metastasis suppressors.
Prentice, Leah Marie
core +1 more source
Does kisspeptin signalling have a role in the testes?
Frontiers in Endocrinology, 2013 Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that regulate the mammalian reproductive axis by a central action in the hypothalamus to stimulate GnRH release. Kisspeptins and their receptor (Gpr54 also called Kiss1r) are
Mei eHua +4 more
doaj +1 more source