Results 81 to 90 of about 4,400 (198)

An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

Advanced Healthcare Materials, Volume 13, Issue 29, November 22, 2024.
The analgesics currently employed in tumor are immunosuppressive. A painless administration of Esketamine combined with Cisplatin (DDP)co‐loaded in a thermo‐sensitive injectable hydrogel (PDEH) is designed to improve the immunosuppressive tumor microenvironment (TME) by activating Dendritic Cells (DCs), interferon‐γ (IFN‐γ) cells and inhibiting ...
Xiali Yin, Yaohua Ke, Ying Liang, Shuxian Zhang, Ziqi Chen, Lixia Yu, Ming Jiang, Qin Liu, Xiaoping Gu   +8 more
wiley   +1 more source

Interactions of GPR54 and GPR147 receptors with RF-amide ligands [PDF]

, 2014
Includes bibliographical references.G protein-coupled receptors play a key role in cellular signaling by transducing extracellular signals via G proteins to elicit intracellular responses.
Hendrikse, Megan
core   +1 more source

Phoenixin knockout mice show no impairment in fertility or differences in metabolic response to a high‐fat diet, but exhibit behavioral differences in an open field test

Journal of Neuroendocrinology, Volume 36, Issue 10, October 2024.
Phoenixin (PNX) is a peptide that had been linked to the control of reproduction and energy homeostasis but the homozygous knockout (KO) of PNX did not impact fertility or the amount of weight gained on a high fat diet, possibly due to compensation. PNX has also been demonstrated to have anti‐inflammatory effects in vivo and in vitro but we found that ...
Emma K. McIlwraith, Neruja Loganathan, Kimberly W. Y. Mak, Wenyuan He, Denise D. Belsham   +4 more
wiley   +1 more source

Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?

Cellular Physiology and Biochemistry, 2018
Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and ...
Camila M. Trevisan, Erik Montagna, Renato de Oliveira, Denise M. Christofolini, Caio P. Barbosa, Keith A. Crandall, Bianca  Bianco   +6 more
doaj   +1 more source

A career in numbers: A citation network analysis of the work of RP Millar and his contribution to GnRH research

Journal of Neuroendocrinology, Volume 36, Issue 10, October 2024.
Here, we use citation network analysis in a novel manner to identify the particular topics to which RP Millar's papers have made a particular contribution. This analysis shows that it makes no sense to conceive of the citation impact of an author in isolation; it depends on the existence of a receptive community that is alert to the potential utility ...
Rhodri I. Leng, Gareth Leng
wiley   +1 more source

Kisspeptin Activates Ankrd 26 Gene Expression in Migrating Embryonic GnRH Neurons

Frontiers in Endocrinology, 2016
Kisspeptin, a newly discovered neuropeptide regulates gonadotropin-releasing hormone (GnRH). Kisspeptins are a large RF-amide family of peptides. The kisspeptin coded by kiss1 gene is a 145-amino acid- protein that is cleaved to C-terminal peptide ...
Tomoko eSoga, Lim Wei Ling, Alan Soo-Beng Khoo, Ishwar S Parhar   +3 more
doaj   +1 more source

Dual fluorescence in situ hybridization showing that isotocin and vasotocin neurons express gpr54-2.

, 2013
Isotocin neurons (A; green) and vasotocin neurons (D; green) express gpr54-2 (B, E; magenta). Merged photographs are shown in C and F. On the other hand, neurons that do not express isotocin or vasotocin (green) express gpr54-1(magenta) mRNA (G–I, and J ...
Yasuhisa Akazome (407147), Kataaki Okubo (407149), Yoshitaka Oka (407150), Yuta Mitani (407148), Shinji Kanda (407146)   +4 more
core   +1 more source

Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway

, 2021
Oxidative stress-induced neuron apoptosis plays a crucial role in the early brain injury (EBI) after subarachnoid hemorrhage (SAH). Kisspeptin has been reported as antioxidant to reduce oxidative stress-induced neuronal cell death through G protein ...
Huang, Lei, Fang, Yuanjian, Lu, Qin, Tang, Lihui, Huang, Yi, Tang, Jiping, Lian, Lifei, Liu, Rui, Ren, Reng, Chen, Gao, Zhang, John H., Li, Dujuan, Guo, Yong, Hu, Yongmei, Reng Ren, Lei Huang, Rui Liu, Yuanjian Fang, Gao Chen, Jiping Tang, Yongmei Hu, Qin Lu, Yi Huang, Lihui Tang, Dujuan Li, John H. Zhang, Yong Guo, Lifei Lian   +27 more
core   +1 more source

Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential

Annals of the New York Academy of Sciences, Volume 1540, Issue 1, Page 47-60, October 2024.
The neuropeptide kisspeptin is a critical endogenous activator of the reproductive system. Notably, both kisspeptin and its receptor are expressed in the key bone cells, osteoblasts, and osteoclasts, suggesting direct bone effects. In this review, we examine the evidence derived from in vitro experiments through to in vivo and clinical studies ...
Edouard G. Mills, Ali Abbara, Waljit S. Dhillo, Alexander N. Comninos   +3 more
wiley   +1 more source

KISS1 and Its G Protein-Coupled Receptor (GPR54) in Cancer Progression and Metastasis

, 2012
Activation of G-protein coupled receptor 54 (GPR54) signaling generated by kisspeptins (endogenous GPR54 ligands encoded by KISS1 gene) has been known to regulate puberty and to suppress cancer metastasis. However, an endogenous GPR54 signaling in cancer
Cho, Sunggook Gook
core