Results 101 to 110 of about 4,400 (198)

Absence of GPR54 and TACR3 mutations in sporadic cases of idiopathic central precocious puberty

, 2014
Background/Aims: Kisspeptin (KISS1)/GPR54 (KISSR) signaling complex and neurokinin B (NKB)/NKB receptor (TACR3) signaling have been proposed as an integral part of the network coordinating GnRH release.
Louizou, E., Kambouris, M., De Roux, N., Kanaka-Gantenbein, C., Leka-Emiri, S., Chrousos, G.   +5 more
core   +1 more source

DIG-labelled in situ hybridization of gpr54-1 shows localization of gpr54-1 mRNA positive cells.

, 2013
gpr54-1 mRNA positive neurons are localized in POp, POm (A), Vd/Vs/Vp (not shown), and habenula (Hb; B). Scale bars: 50 µm.
Yasuhisa Akazome (407147), Kataaki Okubo (407149), Yoshitaka Oka (407150), Yuta Mitani (407148), Shinji Kanda (407146)   +4 more
core   +1 more source

An Isolated Hypogonadotropic Hypogonadism due to a L102P Inactivating Mutation of KISS1R/GPR54 in a Large Family

Case Reports in Pediatrics, 2019
KISS1R (GPR54) mutations have been reported in several patients with congenital normosmic idiopathic hypogonadotropic hypogonadism (nIHH). We aim to describe in detail nIHH patients with KISS1R (GPR54) mutations belonging to one related extended family ...
Ahmad J. Alzahrani, Azzam Ahmad, Tariq Alhazmi, Lujin Ahmad   +3 more
doaj   +1 more source

Molecular and clinical investigation of children with disorders of puberty: GPR54 gene and relevant genes

, 2014
Background: Kisspeptin (KISS1)/GPR54 (KISSR) signaling complex and Neurokinin B (NKB)/ NKB receptor (TACR3) signaling have been proposed as an integral part of the network coordinating GnRH release.
Leka-Emiri, Sofia, Λέκα-Εμίρη, Σοφία, Σοφία Λέκα-Εμίρη   +2 more
core   +1 more source

The role of kisspeptin/GPR54 in the reproductive system.

In vivo (Athens, Greece), 2011
The Kiss-1 gene encodes a secreted protein that is proteolytically cleaved to produce a number of structurally related peptides, with high interspecies conservation, globally termed kisspeptins. The original niche for the role of kisspeptin in human physiology is derived from cancer biology, with the loss of Kiss-1 expression being associated with poor
E, Papaoiconomou, P, Msaouel, A, Makri, E, Diamanti-Kandarakis, M, Koutsilieris   +4 more
openaire   +1 more source

G_q/11 and β-arrestin-dependent GPR54-coupled pathways regulate the spatial distribution of pERK.

, 2013
Immunofluorescence analysis of GPR54 expression and pERK levels in GPR54-EYFP overexpressing Gq/11 and β-Arr KO MEFs and their WT parents before and after 10 minutes of Kp-10 treatment.
Andy V. Babwah (215961), Jacob M. Szereszewski (361527), Macarena Pampillo (215952), Maryse R. Ahow (361528), Moshmi Bhattacharya (215963), Stefan Offermanns (223955)   +5 more
core   +1 more source

The expression and function of gpr54a and gpr54b in allotriploid crucian carp and diploid red crucian carp (Carassius auratus red var.)

Reproduction and Breeding
The kisspeptin receptor (GPR54), a member of the G-protein-coupled receptors, plays a central role in regulating reproduction. However, research on GPR54 in allotriploid fish remains limited.
Lu Huang, Qiubei Wang, Shuxin Zhang, Faxian Yu, Shengnan Li, Huan Zhong, Rurong Zhao, Min Tao   +7 more
doaj   +1 more source

Dual fluorescence in situ hybridization showing that kisspeptin receptors (gpr54-1 and -2) are highly expressed in the neurons (magenta) adjacent to the GnRH1 neurons (green) in the POA.

, 2013
gpr54-1 mRNA (B) is expressed by neurons in proximity to the ventrolateral group of GnRH1 neurons in the POA (A; merged photo in C). gpr54-2 mRNA (E) is expressed in neurons near the dorsomedial group of GnRH1 neurons in the POA (D; merged photo in F ...
Yasuhisa Akazome (407147), Kataaki Okubo (407149), Yoshitaka Oka (407150), Yuta Mitani (407148), Shinji Kanda (407146)   +4 more
core   +1 more source

GPR54 gene analysis in patients with idiopathic central pubertal disorders

, 2008
O complexo de sinalização kisspeptina-GPR54 é um regulador chave para ativação dos neurônios de GnRH e do eixo reprodutivo. Mutações inativadoras no GPR54 foram identificadas em pacientes com hipogonadismo hipogonadotrófico normósmico isolado (HHIn).
Milena Gurgel Teles Bezerra, Bezerra, Milena Gurgel Teles   +1 more
core   +1 more source

IHC of GPR54 expression in the placentas of Control A (A), ePE (B), Control B (C), lPE (D), isotype control (E), positive control (F), negative control (G).

, 2013
Panel H shows GPR54 immunity intensity score semiquantitation. GPR54 was detected in syncytiotrophoblast from ePE and Control A, and hardly detected from lPE and Control B.
Tao Shang (299590), Caixia Liu (299589), Chunhui Wang (141889), Jiao Zhao (92360), Chong Qiao (299588)   +4 more
core   +1 more source