Results 101 to 110 of about 4,181 (199)

Luciferase assays for the activation of two types of receptors, Gpr54-1 and Gpr54-2, by the ligands, Kiss1 and Kiss2.

, 2013
Medaka gpr54-1 (A, C) or gpr54-2 (B, D) cDNA was transfected to COS-7 cells with SRE-luc or CRE-luc vector. Various concentrations of medaka Kiss1 and Kiss2 were applied to the culture medium, and the luciferase activity was measured.
Yasuhisa Akazome (407147), Kataaki Okubo (407149), Yoshitaka Oka (407150), Yuta Mitani (407148), Shinji Kanda (407146)   +4 more
core   +1 more source

Supplementary Movie 1 from GPR54 Is a Target for Suppression of Metastasis in Endometrial Cancer

, 2011
Supplementary Movie 1 from GPR54 Is a Target for Suppression of Metastasis in Endometrial ...
Hyun Sook Kang (14917305), Tsukasa Baba (3430766), Noriomi Matsumura (690046), Shinya Oishi (164565), Ikuo Konishi (690047), Nobutaka Fujii (164590), Junzo Hamanishi (3430763), Eiji Kondoh (4399381), Yumiko Yoshioka (3430775), Masaki Mandai (724217), Budiman Kharma (14917302), Susan K. Murphy (7312109)   +11 more
core   +1 more source

G_q/11 and β-arrestin-dependent GPR54-coupled pathways regulate the spatial distribution of pERK.

, 2013
Immunofluorescence analysis of GPR54 expression and pERK levels in GPR54-EYFP overexpressing Gq/11 and β-Arr KO MEFs and their WT parents before and after 10 minutes of Kp-10 treatment.
Andy V. Babwah (215961), Jacob M. Szereszewski (361527), Macarena Pampillo (215952), Maryse R. Ahow (361528), Moshmi Bhattacharya (215963), Stefan Offermanns (223955)   +5 more
core   +1 more source

The expression and function of gpr54a and gpr54b in allotriploid crucian carp and diploid red crucian carp (Carassius auratus red var.)

Reproduction and Breeding
The kisspeptin receptor (GPR54), a member of the G-protein-coupled receptors, plays a central role in regulating reproduction. However, research on GPR54 in allotriploid fish remains limited.
Lu Huang, Qiubei Wang, Shuxin Zhang, Faxian Yu, Shengnan Li, Huan Zhong, Rurong Zhao, Min Tao   +7 more
doaj   +1 more source

GPR54 is coupled to ERK MAPK pathway in WT MEFs.

, 2013
Representative autoradiographs (A and C) and densitometric analyses (B and D) showing the expression of total and activated ERK1/2 in GPR54 overexpressing WT1 (β-arrestin-1 KO parent) and WT2 (β-arrestin-2 and 1/2 KO parent) MEFs following 10-minute ...
Andy V. Babwah (215961), Jacob M. Szereszewski (361527), Macarena Pampillo (215952), Maryse R. Ahow (361528), Moshmi Bhattacharya (215963), Stefan Offermanns (223955)   +5 more
core   +1 more source

DIG-labelled in situ hybridization of the brain regions surrounding the three types of GnRH neurons (B: gnrh1, E: gnrh2, H: gnrh3), showing the presence or absence of expressions for the kisspeptin receptors, gpr54-1 or gpr54-2, in these regions.

, 2013
The results for gpr54-1 mRNA signals (A, D, G) and gpr54-2 mRNA signals (C, F, I) show that the gpr54-1- and gpr54-2-expressing neurons are localized in the POA surrounding the GnRH1 neurons (A–C), but not in the midbrain tegmentum surrounding the GnRH2 ...
Yasuhisa Akazome (407147), Kataaki Okubo (407149), Yoshitaka Oka (407150), Yuta Mitani (407148), Shinji Kanda (407146)   +4 more
core   +1 more source

Metastin and GPR54 protein expressions in early-onset and late-onset preeclamptic placenta.

, 2013
(A) Representative western blot of metastin and GPR54 expressions in placenta of patients with ePE and lPE compared with the matched controls. Thirty micrograms of total protein was separated on 10% SDS-PAGE gel. β-actin was used as a loading control. (B)
Tao Shang (299590), Caixia Liu (299589), Chunhui Wang (141889), Jiao Zhao (92360), Chong Qiao (299588)   +4 more
core   +1 more source

The role of kisspeptin/GPR54 in the reproductive system.

In vivo (Athens, Greece), 2011
The Kiss-1 gene encodes a secreted protein that is proteolytically cleaved to produce a number of structurally related peptides, with high interspecies conservation, globally termed kisspeptins. The original niche for the role of kisspeptin in human physiology is derived from cancer biology, with the loss of Kiss-1 expression being associated with poor
E, Papaoiconomou, P, Msaouel, A, Makri, E, Diamanti-Kandarakis, M, Koutsilieris   +4 more
openaire   +1 more source

p53 Mediates GnRH Secretion via Lin28/let-7 System in GT1-7 Cells

Diabetes, Metabolic Syndrome and Obesity, 2020
Ting Chen, Haiying Wu, Xiuli Chen, Rongrong Xie, Fengyun Wang, Hui Sun, Linqi Chen Department of Endocrinology, Genetics and Metabolism, Children’s Hospital of Soochow University, Suzhou 215000 Jiangsu, People’s Republic of ...
Chen T, Wu H, Chen X, Xie R, Wang F, Sun H, Chen L   +6 more
doaj  

GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Galpha(q/11) and beta-arrestin-dependent manner

G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation.
Pampillo, M., Bhattacharya, M., Ahow, M. R., Babwah, A. V., Szereszewski, J. M., Offermanns, S.   +5 more
core   +2 more sources