Results 61 to 70 of about 4,400 (198)
Hyperalgesic activity of kisspeptin in mice
Molecular Pain, 2011 Background Kisspeptin is a neuropeptide known for its role in the hypothalamic regulation of the reproductive axis. Following the recent description of kisspeptin and its 7-TM receptor, GPR54, in the dorsal root ganglia and dorsal horns of the spinal ...
Spampinato Simona +9 more
doaj +1 more source
Kisspeptins and GPR54—The new biology of the mammalian GnRH axis [PDF]
Cell Metabolism, 2005 Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis.
openaire +2 more sources
Mitochondrial‐Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential
Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.Age‐related mitochondrial dysfunction in oocytes and sperm is characterized by increased oxidative stress, mtDNA damage, impaired mitochondrial biogenesis, and defective mitophagy, contributing to reduced gamete quality, aneuploidy, impaired fertilization, and embryo failure.
Binarwan Halim +2 more
wiley +1 more source
Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling [PDF]
Reproduction, 2006 Abstract The Kiss1 gene codes for a family of peptides that act as endogenous ligands for the G protein-coupled receptor GPR54. Spontaneous mutations or targeted deletions of GPR54 in man and mice produce hypogonadotropic hypogonadism and infertility.
Jeremy T, Smith +2 more
openaire +2 more sources
Obesity Reviews, Volume 27, Issue 1, Page 1-21, January 2026.ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic–pituitary–ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The risk of complications during pregnancy, such as gestational diabetes mellitus (GDM) and preeclampsia (PE)
Shaohua Zhang +5 more
wiley +1 more source
International Journal of Genomics, Volume 2026, Issue 1, 2026.Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy. Here, we conducted a comprehensive investigation of KISS1 across various cancers, with a specific focus on breast cancer, using TCGA and GTEx datasets.
Chunbiao Wu +8 more
wiley +1 more source
Antiproliferative effects of kisspeptin-10 depend on artificial GPR54 (KISS1R) expression levels
, 2013 Kisspeptins are peptides derived from the metastasis suppressor gene KISS1 interacting with GPR54 as their corresponding receptor. The KISS1/GPR54 system is one regulator of cellular motility mechanisms leading to decreased migration and invasion.
Ziegler, Elke +3 more
core +1 more source
Advanced Science, Volume 12, Issue 38, October 13, 2025.This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang +12 more
wiley +1 more source
MKRN3 and KISS1R mutations in precocious and early puberty
Italian Journal of Pediatrics, 2020 Background Pubertal timing is known to be influenced by interactions among various genetic, nutritional, environmental and socio-economic factors, although the ultimate mechanisms underlying the increase in pulsatile GnRH secretion at puberty have yet to
Sara Pagani +8 more
doaj +1 more source
Association analysis of polymorphisms of G protein-coupled receptor 54 gene exons with reproductive traits in Jiaxing Black sows [PDF]
Asian-Australasian Journal of Animal Sciences, 2019 Objective The aim of this study was to detect single nucleotide polymorphisms (SNP) of G protein-coupled receptor 54 (GPR54) gene and explore association of this candidate gene with reproductive traits in Jiaxing Black sows.
Fen Wu +6 more
doaj +1 more source