Results 61 to 70 of about 4,181 (199)

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang, Wengui Lu, Zhifei Cheng, Luyao Wang, Zhenzhen Jiang, Yike Yue, Pengyu Jiang, Zehua Xia, Lei He, Fengying Wang, Limin Wu, Qi Wang, Hui Han   +12 more
wiley   +1 more source

KISS1 and Its G Protein-Coupled Receptor (GPR54) in Cancer Progression and Metastasis [PDF]

, 2010
Activation of G-protein coupled receptor 54 (GPR54) signaling generated by kisspeptins (endogenous GPR54 ligands encoded by KISS1 gene) has been known to regulate puberty and to suppress cancer metastasis. However, an endogenous GPR54 signaling in cancer
Cho, Sunggook Gook
core  

GPR54 gene analysis in patients with idiopathic central pubertal disorders

, 2008
O complexo de sinalização kisspeptina-GPR54 é um regulador chave para ativação dos neurônios de GnRH e do eixo reprodutivo. Mutações inativadoras no GPR54 foram identificadas em pacientes com hipogonadismo hipogonadotrófico normósmico isolado (HHIn).
Milena Gurgel Teles Bezerra, Bezerra, Milena Gurgel Teles   +1 more
core   +1 more source

MKRN3 and KISS1R mutations in precocious and early puberty

Italian Journal of Pediatrics, 2020
Background Pubertal timing is known to be influenced by interactions among various genetic, nutritional, environmental and socio-economic factors, although the ultimate mechanisms underlying the increase in pulsatile GnRH secretion at puberty have yet to
Sara Pagani, Valeria Calcaterra, Gloria Acquafredda, Chiara Montalbano, Elena Bozzola, Pietro Ferrara, Manuela Gasparri, Alberto Villani, Mauro Bozzola   +8 more
doaj   +1 more source

Neuroendocrine mechanisms responsible for elevated gonadotrophin‐releasing hormone and luteinising hormone pulses in polycystic ovary syndrome

Journal of Neuroendocrinology, Volume 37, Issue 8, August 2025.
Abstract Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in premenopausal individuals with ovaries worldwide. Despite the diagnostic features of anovulation, ovarian cysts, and hyperandrogenemia, which indicate that ovary dysfunction is the cause of the syndrome, changes in central neuroendocrine circuits are a ...
Aleisha M. Moore
wiley   +1 more source

Association analysis of polymorphisms of G protein-coupled receptor 54 gene exons with reproductive traits in Jiaxing Black sows [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective The aim of this study was to detect single nucleotide polymorphisms (SNP) of G protein-coupled receptor 54 (GPR54) gene and explore association of this candidate gene with reproductive traits in Jiaxing Black sows.
Fen Wu, Wei Zhang, Qian-Qian Song, Hai-Hong Li, Ming-Shu Xu, Guo-Liang Liu, Jin-Zhi Zhang   +6 more
doaj   +1 more source

Groundwater Flooding of Superficial Gravels in an Urbanized Catchment

Journal of Flood Risk Management, Volume 18, Issue 2, June 2025.
ABSTRACT Groundwater behavior in superficial gravel aquifers is globally poorly understood, especially across urban regions where drinking water is sourced from elsewhere. This study focuses on one such region around Staines, SE UK, where local River Terrace Gravels form a thin (< 10 m) superficial aquifer.
Jonathan D. Paul, Aneena Ajmi, Doris Bolaji‐Dada, Samuel Bordessoule   +3 more
wiley   +1 more source

Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract Kisspeptinergic signaling is well‐established as crucial for the regulation of reproduction, but its potential broader role in brain function is less understood. This study investigates the distribution and chemotyping of kisspeptin‐expressing neurons within the mouse brain.
Vito S. Hernández, Mario A. Zetter, Oscar R. Hernández‐Pérez, Rafael Hernández‐González, Ignacio Camacho‐Arroyo, Robert P. Millar, Lee E. Eiden, Limei Zhang   +7 more
wiley   +1 more source

In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation. [PDF]

PLoS ONE, 2017
Kisspeptins (KPs) and their receptor (GPR54 or KiSS1R) play a key-role in regulation of the hypothalamic-pituitary-gonadal axis and are therefore interesting targets for therapeutic interventions in the field of reproductive endocrinology. As dogs show a
C H J Albers-Wolthers, J de Gier, M Walen, P J S van Kooten, C B Lambalk, P A J Leegwater, B A J Roelen, A C Schaefers-Okkens, V P M G Rutten, R P M Millar, H S Kooistra   +10 more
doaj   +1 more source

Molecular and clinical investigation of children with disorders of puberty: GPR54 gene and relevant genes

, 2014
Background: Kisspeptin (KISS1)/GPR54 (KISSR) signaling complex and Neurokinin B (NKB)/ NKB receptor (TACR3) signaling have been proposed as an integral part of the network coordinating GnRH release.
Λέκα-Εμίρη, Σοφία, Leka-Emiri, Sofia   +1 more
core   +1 more source