Results 11 to 20 of about 4,181 (199)

The kisspeptin (KiSS-1)/GPR54 system in cancer biology

Cancer Treatment Reviews, 2008
Kisspeptin (KiSS-1) gene, initially described as a melanoma metastasis suppressor gene, encodes a number of peptides (kp-54, kp-14, kp-13, kp-10), which are endogenous ligands to a G protein-coupled receptor, referred as hOT7T175 or AXOR12 or GPR54. So far intensive investigation has provided substantiate evidence supporting the role of KiSS-1/GPR54 ...
Peter Lembessis, Michael Koutsilieris, Nikolaos Pissimissis   +2 more
exaly   +5 more sources

Kisspeptin and GPR54 Receptor Expression in Endometrial Cancer Tissue

Cancers, 2023
Kisspeptin (KISS) is a natural peptide—discovered in 1996 as a factor inhibiting the ability to metastasize in malignant melanoma. This protein plays also a regulatory role in the process of puberty, the menstrual cycle, spermatogenesis, implantation and development of the human placenta.
Marek Gowkielewicz, Aleksandra Lipka, Aleksandra Piotrowska, Marta Szadurska-Noga, Jacek J. Nowakowski, Ewa Lepiarczyk, Marta Wiszpolska, Tomasz Waśniewski, Piotr Dzięgiel, Jerzy Kaleczyc, Mariusz Krzysztof Majewski, Marta Majewska   +11 more
openaire   +3 more sources

Kisspeptin Receptor GPR54 Promotes Adipocyte Differentiation and Fat Accumulation in Mice

Frontiers in Physiology, 2018
GPR54, Kisspeptin-1 receptor (KISS1R), a member of rhodopsin family, plays a critical role in puberty development and has been proposed to be involved in regulation of energy metabolism.
Tongtong Wang, Xueqin Cui, Ling Xie, Roumei Xing, Panpan You, Yongliang Zhao, Yiqing Yang, Yongqian Xu, Li Zeng, Huaqing Chen, Mingyao Liu, Mingyao Liu   +11 more
doaj   +2 more sources

GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner. [PDF]

PLoS ONE, 2010
G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation.
Jacob M Szereszewski, Macarena Pampillo, Maryse R Ahow, Stefan Offermanns, Moshmi Bhattacharya, Andy V Babwah   +5 more
doaj   +2 more sources

GPR54 Is a Target for Suppression of Metastasis in Endometrial Cancer [PDF]

Molecular Cancer Therapeutics, 2011
Abstract Invasion into deep myometrium and/or lymphovascular space is a well-known risk factor for endometrial cancer metastasis, resulting in poor prognosis. It is therefore clinically important to identify novel molecules that suppress tumor invasion.
Hyun Sook, Kang, Tsukasa, Baba, Masaki, Mandai, Noriomi, Matsumura, Junzo, Hamanishi, Budiman, Kharma, Eiji, Kondoh, Yumiko, Yoshioka, Shinya, Oishi, Nobutaka, Fujii, Susan K, Murphy, Ikuo, Konishi   +11 more
openaire   +3 more sources

Novel DNA variation of GPR54 gene in familial central precocious puberty

Italian Journal of Pediatrics, 2019
Background Puberty can be considered the end point of a maturation process which is defined by the dynamic interactions of genes and environmental factors during prenatal and postnatal development.
Nosrat Ghaemi, Martha Ghahraman, Samaneh Noroozi Asl, Rahim Vakili, Fatemeh Fardi Golyan, Meysam Moghbeli, Mohammad Reza Abbaszadegan   +6 more
doaj   +2 more sources

GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness. [PDF]

PLoS ONE, 2011
Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans. However, recent
Mateusz Zajac, Jeffrey Law, Dragana Donna Cvetkovic, Macarena Pampillo, Lindsay McColl, Cynthia Pape, Gianni M Di Guglielmo, Lynne M Postovit, Andy V Babwah, Moshmi Bhattacharya   +9 more
doaj   +2 more sources

Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma [PDF]

BMC Medicine, 2007
Background Kisspeptins and their G-protein coupled receptor, GPR54 are required for GnRH release and have been associated with anti-metastatic tumour cell behaviour in model systems.
Mehl Erika, Kenney Challayne, Santos Jennifer L, McKinney Steven, Köbel Martin, Kalloger Steve, Klausen Christian, Prentice Leah M, Gilks C Blake, Leung Peter, Swenerton Ken, Huntsman David G, Aparicio Samuel AJ   +12 more
doaj   +3 more sources

Involvement of the kisspeptin system in regulation of sexual behaviors in medaka [PDF]

iScience
Summary: In mammals, kisspeptin (Kiss1) neurons are generally considered as a sex steroid-dependent key regulator of hypothalamic-pituitary-gonadal (HPG) axis.
Mikoto Nakajo, Shinji Kanda, Yoshitaka Oka   +2 more
doaj   +2 more sources

Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway [PDF]

Journal of Neuroinflammation
Background Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions. While neuroendocrine-immune system dysfunction plays a crucial role in the development of autoimmune diseases, its involvement in MG remains largely unexplored.
Dan Lu, Linqi Liu, Wenjun Que, Rui Fan, Pingyang Ke, Jing Dong, Yaoqi Gan, Fei Xiao   +7 more
doaj   +2 more sources