Results 11 to 20 of about 4,400 (198)

Design and synthesis of fluorescent probes for GPR54 [PDF]

Bioorganic & Medicinal Chemistry, 2014
Kisspeptins are neuropeptides that induce the secretion of gonadotropin-releasing hormone via the activation of the cognate receptor, G-protein coupled receptor 54 (GPR54). The kisspeptin-GPR54 axis is associated with the onset of puberty and the maintenance of the reproductive system.
Kaneda, Masato, Misu, Ryosuke, Ohno, Hiroaki, Hirasawa, Akira, Ieda, Nahoko, Uenoyama, Yoshihisa, Tsukamura, Hiroko, Maeda, Kei-ichiro, Oishi, Shinya, Fujii, Nobutaka   +9 more
openaire   +5 more sources

GPR54 Is a Target for Suppression of Metastasis in Endometrial Cancer [PDF]

Molecular Cancer Therapeutics, 2011
Abstract Invasion into deep myometrium and/or lymphovascular space is a well-known risk factor for endometrial cancer metastasis, resulting in poor prognosis. It is therefore clinically important to identify novel molecules that suppress tumor invasion.
Hyun Sook, Kang, Tsukasa, Baba, Masaki, Mandai, Noriomi, Matsumura, Junzo, Hamanishi, Budiman, Kharma, Eiji, Kondoh, Yumiko, Yoshioka, Shinya, Oishi, Nobutaka, Fujii, Susan K, Murphy, Ikuo, Konishi   +11 more
openaire   +3 more sources

Kisspeptin and GPR54 Receptor Expression in Endometrial Cancer Tissue

Cancers, 2023
Kisspeptin (KISS) is a natural peptide—discovered in 1996 as a factor inhibiting the ability to metastasize in malignant melanoma. This protein plays also a regulatory role in the process of puberty, the menstrual cycle, spermatogenesis, implantation and development of the human placenta.
Marek Gowkielewicz, Aleksandra Lipka, Aleksandra Piotrowska, Marta Szadurska-Noga, Jacek J. Nowakowski, Ewa Lepiarczyk, Marta Wiszpolska, Tomasz Waśniewski, Piotr Dzięgiel, Jerzy Kaleczyc, Mariusz Krzysztof Majewski, Marta Majewska   +11 more
openaire   +3 more sources

Kisspeptin Receptor GPR54 Promotes Adipocyte Differentiation and Fat Accumulation in Mice

Frontiers in Physiology, 2018
GPR54, Kisspeptin-1 receptor (KISS1R), a member of rhodopsin family, plays a critical role in puberty development and has been proposed to be involved in regulation of energy metabolism.
Tongtong Wang, Xueqin Cui, Ling Xie, Roumei Xing, Panpan You, Yongliang Zhao, Yiqing Yang, Yongqian Xu, Li Zeng, Huaqing Chen, Mingyao Liu, Mingyao Liu   +11 more
doaj   +2 more sources

Novel DNA variation of GPR54 gene in familial central precocious puberty

Italian Journal of Pediatrics, 2019
Background Puberty can be considered the end point of a maturation process which is defined by the dynamic interactions of genes and environmental factors during prenatal and postnatal development.
Nosrat Ghaemi, Martha Ghahraman, Samaneh Noroozi Asl, Rahim Vakili, Fatemeh Fardi Golyan, Meysam Moghbeli, Mohammad Reza Abbaszadegan   +6 more
doaj   +2 more sources

GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness. [PDF]

PLoS ONE, 2011
Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans. However, recent
Mateusz Zajac, Jeffrey Law, Dragana Donna Cvetkovic, Macarena Pampillo, Lindsay McColl, Cynthia Pape, Gianni M Di Guglielmo, Lynne M Postovit, Andy V Babwah, Moshmi Bhattacharya   +9 more
doaj   +2 more sources

GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. [PDF]

PLoS ONE, 2012
Kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn) are coexpressed within KNDy neurons that project from the hypothalamic arcuate nucleus (ARC) to GnRH neurons and numerous other hypothalamic targets.
Pasha Grachev, Xiao Feng Li, Yuan Shao Lin, Ming Han Hu, Leena Elsamani, Stewart J Paterson, Robert P Millar, Stafford L Lightman, Kevin T O'Byrne   +8 more
doaj   +3 more sources

Ligand selectivity of the sea bass kisspeptin receptors gpr54-1b and gpr54-2b

, 2013
The Kiss/Gpr54 system is considered to be an essential regulator of the reproductive axis in most vertebrate species. The existence of paralogous kisspeptin genes as well as kisspeptin receptor genes has quite recently been reported in several fish and amphibian species.
Espigares, F., Felip, Alicia, Zanuy, Silvia, Gómez Peris, Ana   +3 more
openaire   +2 more sources

Female reproductive maturation in the absence of kisspeptin/GPR54 signaling

Nature Neuroscience, 2011
Puberty onset is initiated in the brain by activation of gonadotropin-releasing hormone (GnRH) neurosecretion. Different permissive signals must be integrated for the initiation of reproductive maturation; however, the neural circuits controlling timely awakening of the reproductive axis are not understood.
Mayer, C., Boehm, U.
openaire   +4 more sources

Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1. [PDF]

CNS Neurosci Ther
The Kisspeptin‐10 (KP‐10)/GPR54 signaling pathway is dysregulated in both individuals with cerebral aneurysms and experimentally induced mice. KP‐10 administration prevents CA formation in wild type but not GPR54 KO mice, highlighting the crucial role of GPR54 in mediating KP‐10's protective effects. KP‐10 inhibits the expression of MMP‐9 and VEGF‐A in
Yu H, Xie M, Liufu X, Xu Y, Chen L.
europepmc   +2 more sources