Results 21 to 30 of about 4,400 (198)

Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis. [PDF]

Adv Biol (Weinh)
This study introduces and investigates different‐sex gonad transplants in a mouse model of gender‐affirming hormone therapy. Ovaries and testes implanted into gonadectomized adults exhibit gametogenesis and steroidogenesis independent of the sex of the host.
Pfau DR, Rionda MA, Cho E, Clark JG, Kruger RE, Chan-Sui RK, Padmanabhan V, Moravek MB, Shikanov A.   +8 more
europepmc   +2 more sources

New Insights in Bovine Follicular Cysts. [PDF]

Reprod Domest Anim
ABSTRACT The aim of the present study was to understand the involved factors in follicular cysts in dairy cows. The study consisted of an in vivo and in vitro approach. The in vivo part, hormonal evaluation (Kisspeptin‐10 [Kp‐10], Gonadotropin inhibiting hormone [GnIH], Luteinizing hormone [LH], Oestrogens [E2] and cortisol) was performed in sera of ...
Carbonari A, Martino NA, Burgio M, Cicirelli V, Frattina L, Dell'Aquila ME, Rizzo A.   +6 more
europepmc   +2 more sources

GPR54 and kisspeptins in vertebrates, from fish to mammals

, 2021
Since the discovery of KISS/GPR54 pair in mammals, distinct kisspeptin forms have been reported in non-mammalian vertebrates, including reptilian, amphibian and fish. There is also evidence that multiple forms of kisspeptin receptors, up to four GPR54 paralogs, appear to exist in vertebrates.
Felip, Alicia, Espigares, F., Escobar, Sebastián, Alvarado, M. V., Zanuy, Silvia, Carrillo, Manuel, Gómez Peris, Ana   +6 more
openaire   +2 more sources

Kisspeptin/Gpr54‐Independent Gonadotrophin‐Releasing Hormone Activity in Kiss1 and Gpr54 Mutant Mice [PDF]

Journal of Neuroendocrinology, 2009
The kisspeptin/Gpr54 signalling pathway plays a critical role in reproduction by stimulating the secretion of gonadotrophin‐releasing hormone (GnRH), yet mice carrying mutations in Kiss1 (which encodes kisspeptin) or Gpr54 exhibit partial sexual ...
Y M, Chan, S, Broder-Fingert, K M, Wong, S B, Seminara   +3 more
openaire   +2 more sources

Neuroendocrine Regulation of Stress‐Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway

Advanced Science, 2022
Emerging evidence suggests that physiological distress is highly correlated with cancer incidence and mortality. However, the mechanisms underlying psychological challenges‐mediated tumor immune evasion are not systematically explored.
Su Zhang, Fangfei Yu, Anran Che, Binghe Tan, Chenshen Huang, Yuxue Chen, Xiaohong Liu, Qi Huang, Wenying Zhang, Chengbin Ma, Min Qian, Mingyao Liu, Juliang Qin, Bing Du   +13 more
doaj   +1 more source

Kisspeptin regulates the development of caprine primordial follicles in vitro

Journal of Animal Reproduction and Biotechnology, 2021
Kisspeptin, a neuropeptide and the master controller of reproductive axis upstream to GnRH neurons, and its receptor are also expressed in extrahypothalamic tissues, such as ovaries.
Manjula Priyantha Sumith Magamage, Sriravali Sathagopam, Kiran Avula, Di Neththi Nimesh Madushanka, Sathya Velmurugan   +4 more
doaj   +1 more source

Kisspeptin/G protein-coupled receptor-54 system as an essential gatekeeper of pubertal development [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2013
Puberty is the end-point of a complex series of developmental events, defined by the dynamic interaction between genetic factors and environmental cues, ultimately leading to the attainment of reproductive capacity.
Young-Jun Rhie
doaj   +1 more source

Regulation of GPR54 Signaling by GRK2 and β-Arrestin [PDF]

Molecular Endocrinology, 2009
AbstractKisspeptin and its receptor, GPR54, are major regulators of the hypothalamic-pituitary-gonadal axis as well as regulators of human placentation and tumor metastases. GPR54 is a Gq/11-coupled G protein-coupled receptor (GPCR), and activation by kisspeptin stimulates phosphatidy linositol 4, 5-biphosphate hydrolysis, Ca2+ mobilization ...
Macarena, Pampillo, Natasha, Camuso, Jay E, Taylor, Jacob M, Szereszewski, Maryse R, Ahow, Mateusz, Zajac, Robert P, Millar, Moshmi, Bhattacharya, Andy V, Babwah   +8 more
openaire   +2 more sources

Neuroanatomical evidence that kisspeptin directly regulates isotocin and vasotocin neurons. [PDF]

PLoS ONE, 2013
Neuropeptide kisspeptin has been suggested to be an essential central regulator of reproduction in response to changes in serum gonadal steroid concentrations.
Shinji Kanda, Yasuhisa Akazome, Yuta Mitani, Kataaki Okubo, Yoshitaka Oka   +4 more
doaj   +1 more source

The role of kisspeptin and GPR54 in the hippocampus

Peptides, 2009
The granule cells of the dentate gyrus form the input stage of the hippocampal trisynaptic circuit and their function is strongly influenced by peptidergic systems. GPR54 is highly and discretely expressed in these cells. We have found that activation of GPR54 with kisspeptin-10 causes a rapid and large increase in the amplitude of excitatory synaptic ...
Amy C. Arai, Nathane Orwig, Yan‐Fang Xia   +2 more
openaire   +3 more sources