GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. [PDF]
PLoS ONE, 2012 Kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn) are coexpressed within KNDy neurons that project from the hypothalamic arcuate nucleus (ARC) to GnRH neurons and numerous other hypothalamic targets.
Pasha Grachev +8 more
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ارزیابی جهش های ژن GPR54 در دختران ایرانی با بلوغ زودرس فامیلیال [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2012 مقدمه: مسیر انتقال پیام GPR54/Kisspeptin به عنوان دروازه و تنظیم کننده فعالیت نورون های آزاد کننده گونادوتروپین و عامل کلیدی شروع بلوغ می باشد. جهش های از دست دهنده عملکرد در ژن گیرنده متصل شونده به پروتیین GPR54 )G با تأخیر بلوغ مرکزی و جهش های کسب ...
نصرت قائمی +4 more
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The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology
Genes and Diseases, 2022 KiSS-1, first identified as an anti-metastasis gene in melanoma, encodes C-terminally amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10.
Nisha Zhu +4 more
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The effect of high-fat diet and exercise on KISS-1/GPR54 expression in testis of growing rats
Nutrition & Metabolism, 2021 Purpose To find the expression of KISS-1 and G protein-coupled receptor 54 in rats testis from PND 21st to 56th. Method 128 three-week-old weaned rats underwent high-fat diet and exercise (60–70% VO2max, 1 h/day, 5 days/week) intervention and were ...
Junpeng Feng +6 more
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Advanced Science, 2022 Emerging evidence suggests that physiological distress is highly correlated with cancer incidence and mortality. However, the mechanisms underlying psychological challenges‐mediated tumor immune evasion are not systematically explored.
Su Zhang +13 more
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Kisspeptin/Gpr54‐Independent Gonadotrophin‐Releasing Hormone Activity in Kiss1 and Gpr54 Mutant Mice [PDF]
Journal of Neuroendocrinology, 2009 The kisspeptin/Gpr54 signalling pathway plays a critical role in reproduction by stimulating the secretion of gonadotrophin‐releasing hormone (GnRH), yet mice carrying mutations in Kiss1 (which encodes kisspeptin) or Gpr54 exhibit partial sexual ...
Y M, Chan +3 more
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Kisspeptin regulates the development of caprine primordial follicles in vitro
Journal of Animal Reproduction and Biotechnology, 2021 Kisspeptin, a neuropeptide and the master controller of reproductive axis upstream to GnRH neurons, and its receptor are also expressed in extrahypothalamic tissues, such as ovaries.
Manjula Priyantha Sumith Magamage +4 more
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Kisspeptin/G protein-coupled receptor-54 system as an essential gatekeeper of pubertal development [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2013 Puberty is the end-point of a complex series of developmental events, defined by the dynamic interaction between genetic factors and environmental cues, ultimately leading to the attainment of reproductive capacity.
Young-Jun Rhie
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Regulation of GPR54 Signaling by GRK2 and β-Arrestin [PDF]
Molecular Endocrinology, 2009 AbstractKisspeptin and its receptor, GPR54, are major regulators of the hypothalamic-pituitary-gonadal axis as well as regulators of human placentation and tumor metastases. GPR54 is a Gq/11-coupled G protein-coupled receptor (GPCR), and activation by kisspeptin stimulates phosphatidy linositol 4, 5-biphosphate hydrolysis, Ca2+ mobilization ...
Macarena, Pampillo +8 more
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Neuroanatomical evidence that kisspeptin directly regulates isotocin and vasotocin neurons. [PDF]
PLoS ONE, 2013 Neuropeptide kisspeptin has been suggested to be an essential central regulator of reproduction in response to changes in serum gonadal steroid concentrations.
Shinji Kanda +4 more
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