Kisspeptin Mitigates Hepatic De Novo Lipogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease [PDF]
CellsThe peptide hormone kisspeptin, signaling via its receptor, KISS1R, decreases hepatic steatosis and protects against metabolic dysfunction-associated steatotic liver disease (MASLD). Enhanced de novo lipogenesis (DNL) contributes to MASLD.
Kimberly Izarraras +5 more
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KISS1/KISS1R In Cancer: Friend or Foe?
Frontiers in Endocrinology, 2018 The KISS1 gene encodes KISS1, a protein that is rapidly processed in serum into smaller but biologically active peptides called kisspeptins (KPs). KISS1 and the KPs signal via the G-protein coupled receptor KISS1R.
Andy V Babwah +2 more
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Genetic variants of the DLK1, KISS1R, MKRN3 genes in girls with precocious puberty [PDF]
Вавиловский журнал генетики и селекцииPrecocious puberty (PP, E30.1, Е22.8, Е30.9 according to ICD 10, MIM 176400, 615346) in children is a disorder in which secondary sexual characteristics appear earlier than the age norm.
E. A. Sazhenova +8 more
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Genetic and epigenetic aspects of the and genes in pubertal development and central precocious puberty: A review [PDF]
Precision and Future Medicine, 2023 The onset of puberty is a pivotal developmental milestone, and the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone is a key factor in the initiation of puberty. Both kisspeptin and its receptor (KISS1) and KISS1 receptor (KISS1R)
Ahreum Kwon
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Pharmaceuticals, 2023 Kisspeptins (KPs, KISS1) and their receptor (KISS1R) play a pivotal role as metastasis suppressor for many cancers. Low or lost KP expression is associated with higher tumor grade, increased metastatic potential, and poor prognosis.
Ina Israel +4 more
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Epigenetics, 2022 Kisspeptin, produced from the brain and peripheral tissues, may constitute an important link in metabolic regulation in response to external cues, such as diet. The kisspeptin system is well described in the brain. However, its function and regulation in
Kamil Ziarniak +8 more
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The Kisspeptin System in Male Reproduction
Endocrines, 2022 The kisspeptin system includes the cleavage products Kiss1 precursor and kisspeptin receptor (Kiss1R). It was originally discovered and studied in cancer metastasis, but the identification of KISS1/KISS1R gene mutations causing hypogonadotropic ...
Rosaria Meccariello
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Two families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 receptor): clinical evaluation and molecular characterization of a novel mutation. [PDF]
PLoS ONE, 2013 CONTEXT: KISS1R mutations have been reported in few patients with normosmic congenital hypogonadotropic hypogonadism (nCHH) (OMIM #146110). OBJECTIVE: To describe in detail nCHH patients with biallelic KISS1R mutations belonging to 2 unrelated families ...
Frédéric Brioude +10 more
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Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model
The Journal of Clinical Investigation, 2022 Nonalcoholic fatty liver disease (NAFLD), the most common liver disease, has become a silent worldwide pandemic. The incidence of NAFLD correlates with the rise in obesity, type 2 diabetes, and metabolic syndrome.
Stephania Guzman +20 more
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Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System [PDF]
Endocrinology and Metabolism, 2016 Kisspeptin signaling at the gonadotropin-releasing hormone (GnRH) neuron is now relatively well characterized and established as being critical for the neural control of fertility.
Xinhuai Liu, Allan E. Herbison
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