Results 1 to 10 of about 2,102 (127)

Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches. [PDF]

Reprod Domest Anim
ABSTRACT Kisspeptin is a peptide that plays a pivotal role in the central regulation of gonadotropins. It is regarded as a key regulator of reproductive processes, including follicular and luteal development and endometrial remodelling. The objective of this study was to investigate the expression of KISS1, its receptor KISS1R and the proliferation ...
Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Özmen Ö, Bozkurt G, Taşan Ş.   +4 more
europepmc   +2 more sources

Kisspeptin Mitigates Hepatic De Novo Lipogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease [PDF]

Cells
The peptide hormone kisspeptin, signaling via its receptor, KISS1R, decreases hepatic steatosis and protects against metabolic dysfunction-associated steatotic liver disease (MASLD). Enhanced de novo lipogenesis (DNL) contributes to MASLD.
Kimberly Izarraras, Ankit Shah, Kavita Prasad, Helena Tan, Zhongren Zhou, Moshmi Bhattacharya   +5 more
doaj   +2 more sources

Kiss1 receptor knockout exacerbates airway hyperresponsiveness and remodeling in a mouse model of allergic asthma [PDF]

Respiratory Research
Background In asthma, sex-steroids signaling is recognized as a critical regulator of disease pathophysiology. However, the paradoxical role of sex-steroids, especially estrogen, suggests that an upstream mechanism or even independent of estrogen plays ...
Nilesh Sudhakar Ambhore, Premanand Balraj, Ashish Kumar, Mohammad Irshad Reza, Yogaraj S. Ramakrishnan, Jacob Tesch, Sahil Lohana, Venkatachalem Sathish   +7 more
doaj   +2 more sources

Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control. [PDF]

J Neuroendocrinol
Abstract Kisspeptin (KP) signaling in the brain is defined by the anatomical distribution of KP‐producing neurons, their fibers, receptors, and connectivity. Technological advances have prompted a re‐evaluation of these chemoanatomical aspects, originally studied in the early years after the discovery of KP and its receptor Kiss1r.
Zhang L, Hernández VS, Zetter MA, Hernández-Pérez OR, Hernández-González R, Camacho-Arroyo I, Eiden LE, Millar RP.   +7 more
europepmc   +2 more sources

Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications. [PDF]

Obes Rev
ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic–pituitary–ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The risk of complications during pregnancy, such as gestational diabetes mellitus (GDM) and preeclampsia (PE)
Zhang S, Sun X, Guan H, Wang R, Zhang W, Xia H.   +5 more
europepmc   +2 more sources

Determination of Biotin Interference in Pediatric Obesity Related ELISA Research Kits Biotin Interference in Manual ELISA Kits. [PDF]

J Clin Lab Anal
In this study, we aimed for the first time to demonstrate biotin interference in ELISA research kits used in the analysis of pediatric obesity parameters other than routine testing. Our study revealed that biotin interaction may occur in manual ELISA kits and may cause erroneous test results.
Kürkçü Kahraman E, Donma O, Donma MM, Yılmaz A, Güzel S.   +4 more
europepmc   +2 more sources

KISS1/KISS1R in Cancer: Friend or Foe?

Frontiers in Endocrinology, 2018
The KISS1 gene encodes KISS1, a protein that is rapidly processed in serum into smaller but biologically active peptides called kisspeptins (KPs). KISS1 and the KPs signal via the G-protein coupled receptor KISS1R.
Andy Babwah, Stephania Guzman, Muriel Brackstone   +2 more
exaly   +3 more sources

Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway

Frontiers in Endocrinology, 2018
A large body of data has established the hypothalamic kisspeptin (KP) and its receptor, KISS1R, as major players in the activation of the neuroendocrine reproductive axis at the time of puberty and maintenance of reproductive capacity in the adult.
Rüdiger Bèhr, Fazal Wahab, Muhammad Shahab   +2 more
exaly   +3 more sources

Genetic variants of the DLK1, KISS1R, MKRN3 genes in girls with precocious puberty [PDF]

Вавиловский журнал генетики и селекции
Precocious puberty (PP, E30.1, Е22.8, Е30.9 according to ICD 10, MIM 176400, 615346) in children is a disorder in which secondary sexual characteristics appear earlier than the age norm.
E. A. Sazhenova, O. Yu. Vasilyeva, E. A. Fonova, M. B. Kankanam Pathiranage, A. Yu. Sambyalova, E. E. Khramova, L. V. Rychkova, S. A. Vasilyev, I. N. Lebedev   +8 more
doaj   +2 more sources

Expression of GnRH, Kisspeptin, and Their Specific Receptors in the Ovary and Uterus in Deslorelin-Treated Late-Prepubertal Bitches [PDF]

Veterinary Sciences
In this study, the expression and localization of gonadotropin-releasing hormone (GnRH1) and kisspeptin (KISS1) and their specific receptors in canine ovarian and uterine tissues were investigated after the application of deslorelin acetate (Suprelorin®,
Muhammet Ali Karadağ, Aykut Gram, Sabine Schäfer-Somi, Selim Aslan, Duygu Kaya   +4 more
doaj   +2 more sources