Results 11 to 20 of about 2,756 (195)
Epigenetics, 2022 Kisspeptin, produced from the brain and peripheral tissues, may constitute an important link in metabolic regulation in response to external cues, such as diet. The kisspeptin system is well described in the brain. However, its function and regulation in
Kamil Ziarniak +8 more
doaj +4 more sources
BMC Research Notes, 2011 Background Pubertal timing is a strongly heritable trait, but no single puberty gene has been identified. Thus, the genetic background of idiopathic central precocious puberty (ICPP) is poorly understood. Overall, the genetic modulation of pubertal onset
Koivu Rosanna +6 more
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Gene structure of the Kiss1 receptor-2 (Kiss1r-2) in the Atlantic halibut: Insights into the evolution and regulation of Kiss1r genes [PDF]
Molecular and Cellular Endocrinology, 2010 Kisspeptin and its receptor, Kiss1r, play an essential role in the control of the onset of puberty in vertebrates. We characterized the cDNA and genomic DNA encoding Kiss1r in Atlantic halibut (Hippoglossus hippoglossus). The 1146bp open reading frame predicts a 381 amino acid protein with high homology to the Kiss1r-2 of other teleost fish ...
Mechaly, Alejandro S. +4 more
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KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis [PDF]
Neuroendocrinology, 2015 Kisspeptin (KP) is now well recognized as a potent stimulator of gonadotropin-releasing hormone (GnRH) secretion and thereby a major regulator of the neuroendocrine-reproductive axis. KP signals via KISS1R, a G protein-coupled receptor (GPCR) that activates the G proteins Gα<sub>q/11</sub>. Modulation of the interaction of KP with KISS1R is
Millar, Robert P., Babwah, Andy V.
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Journal of Molecular Biology, 2021 Kisspeptin receptor (Kiss1R) is an important receptor that plays central regulatory roles in reproduction by regulating hormone release in the hypothalamus. We hypothesize that the formation of heterocomplexes between Kiss1R and other hypothalamus G protein-coupled receptors (GPCRs) affects their cellular signaling.
Ran Ke +5 more
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Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery [PDF]
Reproductive Biology and Endocrinology, 2019 Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role
Yubin Cao +4 more
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Abstract 5213: KiSS1R signaling in breast cancer
Cancer Research, 2010 Abstract KiSS1R, a G-protein coupled receptor (GPCR), and its ligands, collectively known as the kisspeptins, were originally discovered to have anti-metastatic effects. In melanoma, the expression of KiSS1R and the kisspeptins correlates with positive prognosis. However, in breast tumors, higher mRNA expression of KiSS1R and kisspeptins
Matthew M. Zajac +2 more
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KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation [PDF]
Endocrinology, 2011 AbstractThe goal of this study was to investigate how the Arg386Pro mutation prolongs KiSS-1 receptor (KISS1R) responsiveness to kisspeptin, contributing to human central precocious puberty. Confocal imaging showed colocalization of wild-type (WT) KISS1R with a membrane marker, which persisted for up to 5 h of stimulation. Conversely, no colocalization
Suzy D C, Bianco +9 more
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KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion [PDF]
European Journal of Histochemistry, 2011 KISS1 and its receptor, KISS1R, have both been found to be expressed in central nervous system, but few data are present in the literature about their distribution in peripheral nervous structures.
A. Porzionato +6 more
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Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in Prostate Cancer [PDF]
Anticancer Research, 2020 Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. In contrast to localized disease, metastatic PCa leads to increased mortality. Kisspeptin (KISS1) functions as a metastasis suppressor in various cancers. The aim of this study was to detect the expression of KISS1 and its receptor GPR54 (KISS1R) in prostate cancer.The ...
Xoxakos, I. +6 more
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