Results 11 to 20 of about 2,946 (202)

Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway [PDF]

Frontiers in Endocrinology, 2018
A large body of data has established the hypothalamic kisspeptin (KP) and its receptor, KISS1R, as major players in the activation of the neuroendocrine reproductive axis at the time of puberty and maintenance of reproductive capacity in the adult.
Fazal Wahab, Bibi Atika, Farhad Ullah, Muhammad Shahab, Rüdiger Behr, Rüdiger Behr   +5 more
doaj   +5 more sources

Gene structure of the Kiss1 receptor-2 (Kiss1r-2) in the Atlantic halibut: Insights into the evolution and regulation of Kiss1r genes [PDF]

Molecular and Cellular Endocrinology, 2010
Kisspeptin and its receptor, Kiss1r, play an essential role in the control of the onset of puberty in vertebrates. We characterized the cDNA and genomic DNA encoding Kiss1r in Atlantic halibut (Hippoglossus hippoglossus). The 1146bp open reading frame predicts a 381 amino acid protein with high homology to the Kiss1r-2 of other teleost fish ...
Mechaly, Alejandro S., Viñas, Jordi, Murphy, Colleen, Reith, Michael, Piferrer, Francesc   +4 more
openaire   +4 more sources

Formation of Kiss1R/GPER Heterocomplexes Negatively Regulates Kiss1R-mediated Signalling through Limiting Receptor Cell Surface Expression

Journal of Molecular Biology, 2021
Kisspeptin receptor (Kiss1R) is an important receptor that plays central regulatory roles in reproduction by regulating hormone release in the hypothalamus. We hypothesize that the formation of heterocomplexes between Kiss1R and other hypothalamus G protein-coupled receptors (GPCRs) affects their cellular signaling.
Ran Ke, Samson Ian Sam Lok, Kailash Singh, Billy Kwok Chong Chow, Harald Janovjak, Leo Tsz On Lee   +5 more
openaire   +3 more sources

KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion [PDF]

European Journal of Histochemistry, 2011
KISS1 and its receptor, KISS1R, have both been found to be expressed in central nervous system, but few data are present in the literature about their distribution in peripheral nervous structures.
A. Porzionato, G. Fenu, M. Rucinski, V. Macchi, A. Montella, L. K. Malendowicz, R. De Caro   +6 more
doaj   +3 more sources

Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in Prostate Cancer [PDF]

Anticancer Research, 2020
Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. In contrast to localized disease, metastatic PCa leads to increased mortality. Kisspeptin (KISS1) functions as a metastasis suppressor in various cancers. The aim of this study was to detect the expression of KISS1 and its receptor GPR54 (KISS1R) in prostate cancer.The ...
Xoxakos, I., Petraki, C., Msauel, P., Armakolas, A., Grigorakis, A., Stefanakis, S., Koutsilieris, M.   +6 more
core   +5 more sources

Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery [PDF]

Reproductive Biology and Endocrinology, 2019
Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role
Yubin Cao, Zeping Li, Wenyu Jiang, Yan Ling, Haibin Kuang   +4 more
doaj   +3 more sources

Abstract 5213: KiSS1R signaling in breast cancer

Cancer Research, 2010
Abstract KiSS1R, a G-protein coupled receptor (GPCR), and its ligands, collectively known as the kisspeptins, were originally discovered to have anti-metastatic effects. In melanoma, the expression of KiSS1R and the kisspeptins correlates with positive prognosis. However, in breast tumors, higher mRNA expression of KiSS1R and kisspeptins
Matthew M. Zajac, Andy Babwah, Moshmi Bhattacharya   +2 more
openaire   +2 more sources

A Novel KISS1R Loss-of-function Variant in a Chinese Child with Congenital Hypogonadotropic Hypogonadism [PDF]

JCRPE, 2022
Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder, resulting from impaired production, secretion, or action of gonadotropin-releasing hormone (GnRH). Variants of the KISS1R gene can result in CHH.
Peng Zhou, Jin Wu
doaj   +2 more sources

KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation [PDF]

Endocrinology, 2011
AbstractThe goal of this study was to investigate how the Arg386Pro mutation prolongs KiSS-1 receptor (KISS1R) responsiveness to kisspeptin, contributing to human central precocious puberty. Confocal imaging showed colocalization of wild-type (WT) KISS1R with a membrane marker, which persisted for up to 5 h of stimulation. Conversely, no colocalization
Suzy D C, Bianco, Lauren, Vandepas, Mayrin, Correa-Medina, Balázs, Gereben, Abir, Mukherjee, Wendy, Kuohung, Rona, Carroll, Milena G, Teles, Ana Claudia, Latronico, Ursula B, Kaiser   +9 more
openaire   +3 more sources

Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice

Scientific Reports, 2018
The roles of kisspeptin signaling outside the hypothalamus in the brain are unknown. We examined here the impact of Kiss1r-deletion on hippocampus-related behaviors of anxiety and spatial learning in adult male mice using two mouse models.
Sarah Delmas, Robert Porteous, Dave H. Bergin, Allan E. Herbison   +3 more
doaj   +2 more sources