Gallium-68-Labeled KISS1-54 Peptide for Mapping KISS1 Receptor via PET: Initial Evaluation in Human Tumor Cell Lines and in Tumor-Bearing Mice [PDF]
Pharmaceuticals, 2023 Kisspeptins (KPs, KISS1) and their receptor (KISS1R) play a pivotal role as metastasis suppressor for many cancers. Low or lost KP expression is associated with higher tumor grade, increased metastatic potential, and poor prognosis.
Ina Israel +4 more
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Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches. [PDF]
Reprod Domest AnimABSTRACT Kisspeptin is a peptide that plays a pivotal role in the central regulation of gonadotropins. It is regarded as a key regulator of reproductive processes, including follicular and luteal development and endometrial remodelling. The objective of this study was to investigate the expression of KISS1, its receptor KISS1R and the proliferation ...
Korkmaz Ağaoğlu Ö +4 more
europepmc +2 more sources
Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models [PDF]
Journal of Ovarian ResearchPolycystic ovary syndrome (PCOS) and mental health disorders have high rates of co-occurrence. Although the precise pathophysiological mechanisms remain unknown, the observed changes in those conditions may be modulated by kisspeptin (Kiss1), a protein ...
Tingting Mo +11 more
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Gynecological Endocrinology, 2023 Objectives To explore the association of KISS1, LIN28B, vitamin D receptor (VDR), and estrogen receptor α (ERα) gene polymorphisms and the risk of early with fast puberty (EFP) risk, and with hormone levels in EFP cases, in Chinese girls.Methods The ...
Yunwei Li +4 more
doaj +3 more sources
GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice. [PDF]
J NeuroendocrinolAbstract The arcuate nucleus kisspeptin (ARNKISS) neurons intermittently synchronize their activity to operate as the GnRH pulse generator and drive pulsatile reproductive hormone secretion in mammals. Although ARNKISS neurons are known to receive various GABAergic inputs, the effects of GABAA and GABAB receptor modulation on their ability to ...
Eddleston T, Morris PG, Herbison AE.
europepmc +2 more sources
Genetic and epigenetic aspects of the and genes in pubertal development and central precocious puberty: A review [PDF]
Precision and Future Medicine, 2023 The onset of puberty is a pivotal developmental milestone, and the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone is a key factor in the initiation of puberty. Both kisspeptin and its receptor (KISS1) and KISS1 receptor (KISS1R)
Ahreum Kwon
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Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice
Nature Communications, 2023 Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exerting a surge-
Jose M. Ramos-Pittol +14 more
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Frontiers in Cell and Developmental Biology, 2022 Kisspeptins are involved in the regulation of hypothalamic-pituitary-gonadal axis, Leydig cell functions, and testosterone secretion, acting as endogenous ligands of the KISS1 receptor.
Giulia Ricci +12 more
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Upregulation of Kiss-1 and Gpr54 Genes Expression in Pituitary of Male Rats Following the Central Administration of Neuropeptide Y [PDF]
International Journal of Basic Science in Medicine, 2019 Introduction: The neuropeptide Y (NPY) in the neural circuits of the hypothalamus has a stimulating effect on reproductive activities in mammals. Kisspeptin (KiSS1) is a quintessential neurotransmitter in the reproductive axis which directly stimulates ...
Vahid Azizi +3 more
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Frontiers in Oncology, 2023 Metastatic dissemination is still one of the major causes of death of melanoma’s patients. KiSS1 is a metastasis suppressor originally identified in melanoma cells, known to play an important physiological role in mammals’ development and puberty. It has
Carlotta Guzzetti +7 more
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