EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression
Cell Communication and Signaling, 2021 Background During pregnancy, trophoblast cell invasion needs to be finely controlled. Aberrant trophoblast cell invasion is associated with placental diseases.
Lanlan Fang +7 more
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The Kisspeptin System in Male Reproduction
Endocrines, 2022 The kisspeptin system includes the cleavage products Kiss1 precursor and kisspeptin receptor (Kiss1R). It was originally discovered and studied in cancer metastasis, but the identification of KISS1/KISS1R gene mutations causing hypogonadotropic ...
Rosaria Meccariello
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Altered placental expression of kisspeptin and its receptor in pre-eclampsia [PDF]
, 2012 Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy.
Williams, Paula Juliet +3 more
core +1 more source
Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). [PDF]
PLoS ONE, 2014 Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals.
Yali Zhao +4 more
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Kisspeptin Stimulation of Prolactin Secretion Requires Kiss1 Receptor but Not in Tuberoinfundibular Dopaminergic Neurons [PDF]
Endocrinology, 2019 Abstract Kisspeptin has been shown to stimulate prolactin secretion. We investigated whether kisspeptin acts through the Kiss1 receptor (Kiss1r) to regulate dopamine and prolactin. Initially, we evaluated prolactin response in a Kiss1r-deficient mouse line, in which Kiss1r had been knocked into GnRH neurons (Kiss1r−/−R ...
Nayara S S Aquino +8 more
openaire +2 more sources
Estrogen Stimulation of Kiss1 Expression in the Medial Amygdala Involves Estrogen Receptor-α But Not Estrogen Receptor-β [PDF]
Endocrinology, 2016 The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion. Neurons synthesizing kisspeptin are predominantly located in the hypothalamic anteroventral periventricular (AVPV) and arcuate nuclei, but smaller kisspeptin neuronal populations also reside in extrahypothalamic brain regions, such as the medial ...
Shannon B Z, Stephens +4 more
openaire +2 more sources
Journal of Ovarian Research, 2023 Background Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Electroacupuncture (EA) can effectively improve hyperandrogenism and increase ovulation frequency in patients with PCOS.
Ge Xu +6 more
doaj +1 more source
The Journal of Reproduction and Development, 2022 Reproductive function is suppressed during lactation owing to the suckling-induced suppression of the kisspeptin gene (Kiss1) expression in the arcuate nucleus (ARC) and subsequent suppression of luteinizing hormone (LH) release.
Arisa SUGIMOTO +5 more
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In-vitro effects of the urotensin-II peptide and its receptor antagonists on mcf-7 breast cancer cell line. [PDF]
J Egypt Natl Canc InstBackground Urotensin-II is a powerful vasoconstrictor peptide. Both the peptide and its receptor, GPR14, affect central nervous system, cardiovascular system, and kidney functions.
Olukman M +5 more
europepmc +2 more sources
Role of Kisspeptin-GPR54 system in regulation of reproductive functions in human and other mammals
Pakistan Journal of Pharmaceutical Sciences, 2021 Kisspeptin is a 54- amino acid peptide that acts as a ligand of a receptor called GPR54 which is basically a transmembrane receptor that spins seven times across the cell membrane and coupled with G-protein.
Ikram Ilahi, Taqweem Ul Haq
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