Results 41 to 50 of about 1,110,898 (202)
GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness. [PDF]
PLoS ONE, 2011 Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans. However, recent
Mateusz Zajac +9 more
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Biomolecules, 2022 The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde +9 more
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Estradiol Regulation of Kiss1 Neurons [PDF]
, 2018 Kisspeptin, encoded by the Kiss1 gene, is required for reproductive function. There are several distinct Kiss1 populations in the brain, and how these kisspeptin neurons are regulated is still not fully understood.
Liaw, Reanna Beverly
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Haploinsufficiency in the Prometastasis Kiss1 Receptor Gpr54 Delays Breast Tumor Initiation, Progression, and Lung Metastasis [PDF]
Cancer Research, 2011 Abstract Activation of KISS1 receptor (KISS1R or GPR54) by its ligands (Kisspeptins) regulates a diverse function both in normal physiology and pathophysiology. In cancer, KISS1R has been implicated in tumor angiogenesis and metastasis, but a broader evaluation of KISS1R in tumorigenesis and tumor progression is yet to be conducted.
Sung-Gook, Cho +7 more
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Frontiers in Oncology, 2022 Nasopharyngeal carcinoma (NPC) is a cancer that occurs in the nasopharynx. Infinite proliferation and distant metastasis are the main characteristics of NPC cells, and the main reason for the current failure of malignant tumor treatment.
Tingting Li +7 more
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A role for GABA agonist in controlling the reproduction of female rats via hypothalamic ghrelin, kisspeptin, and RFRP-3 gene expression [PDF]
The Iranian Journal of Veterinary Science and Technology, 2021 Kisspeptin stimulates gonadotropin releasing hormone (GnRH). The GnRH neurons receive inhibitory inputs from ghrelin, RFamide related peptide-3 (RFRP-3), and gamma-aminobutyric acid (GABA) neurons.
Elaheh Rahimi Rick +4 more
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Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors From Kiss1 Cells [PDF]
Endocrinology, 2013 Abstract Pubertal onset only occurs in a favorable, anabolic hormonal environment. The neuropeptide kisspeptin, encoded by the Kiss1 gene, modifies GnRH neuronal activity to initiate puberty and maintain fertility, but the factors that regulate Kiss1 neurons and permit pubertal maturation remain to be clarified.
Xiaoliang, Qiu +7 more
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Ecotoxicology and Environmental Safety, 2022 Chlorobisphenol A (ClxBPA) is a kind of novel estrogenic compounds. The present study aims to investigate the effects of three ClxBPA compounds on the kisspeptin/G protein-coupled receptor 54 (GPR54, also named KissR1)-gonadotropin-releasing hormone ...
Bingli Lei +5 more
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Animal Biotechnology, 2018 ABSTARCT The neuropeptide kisspeptin (Kp) through its receptor Kiss1r regulates the HPG axis by controlling GnRH release. Since buffalo is a seasonal breeder with problems of delayed puberty and postpartum anestrus, we characterized the Kiss1 and Kiss1r and investigated the immunolocalization in the hypothalamus and corpus luteum (CL). Kiss1 and Kiss1r
Girish Kumar, Mishra +9 more
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Duplicated Kiss1 receptor genes in zebrafish: distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity [PDF]
, 2012 The kisspeptin (Kiss1) and Kiss1 receptor (Kiss1r) pathway plays a central role in the neuroendocrine control of reproduction. In contrast to humans and mammals that have a single Kiss1 gene and a single Kiss1r gene, multiple Kiss ligand and receptor ...
Duan, Cunming, Onuma, Takeshi A.
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