Results 51 to 60 of about 1,354,109 (194)

Sex‐specific expression of estrogen receptors α and β and Kiss1 in the postnatal rat amygdala [PDF]

Journal of Comparative Neurology, 2012
Abstract The rodent amygdaloid complex is composed of numerous subnuclei important for the sex‐specific regulation of sociosexual behavior. Although estrogen receptors (ERs) are critical for organizing functional and cytoarchitectural sex differences in these subnuclei, a detailed developmental profile of ER expression in the ...
Jinyan, Cao, Heather B, Patisaul
openaire   +2 more sources

Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity

Biomolecules, 2022
The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde, Danielle Kulyk, Allison Vanschaik, Sierra Daisey, Catherine Rojas, Kimberly Wiersielis, Ali Yasrebi, Thomas J. Degroat, Yuxiang Sun, Troy A. Roepke   +9 more
doaj   +1 more source

Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models. [PDF]

J Ovarian Res
Polycystic ovary syndrome (PCOS) and mental health disorders have high rates of co-occurrence. Although the precise pathophysiological mechanisms remain unknown, the observed changes in those conditions may be modulated by kisspeptin (Kiss1), a protein ...
Mo T, Qiu Y, He S, Wang G, Li B, Shen Q, Nie X, Wei J, Li N, Pang B, Liu Y, Pan X.   +11 more
europepmc   +2 more sources

GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness. [PDF]

PLoS ONE, 2011
Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans. However, recent
Mateusz Zajac, Jeffrey Law, Dragana Donna Cvetkovic, Macarena Pampillo, Lindsay McColl, Cynthia Pape, Gianni M Di Guglielmo, Lynne M Postovit, Andy V Babwah, Moshmi Bhattacharya   +9 more
doaj   +1 more source

Kiss1 Inhibits the Proliferation of Nasopharyngeal Carcinoma Cells Via Activation of the LKB1/AMPK Pathway

Frontiers in Oncology, 2022
Nasopharyngeal carcinoma (NPC) is a cancer that occurs in the nasopharynx. Infinite proliferation and distant metastasis are the main characteristics of NPC cells, and the main reason for the current failure of malignant tumor treatment.
Tingting Li, Yong Tian, Yixuan Wang, Zhen Cui, Zelai He, Xiao Wu, Yajun Zhang, Hao Jiang   +7 more
doaj   +1 more source

Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors From Kiss1 Cells [PDF]

Endocrinology, 2013
Abstract Pubertal onset only occurs in a favorable, anabolic hormonal environment. The neuropeptide kisspeptin, encoded by the Kiss1 gene, modifies GnRH neuronal activity to initiate puberty and maintain fertility, but the factors that regulate Kiss1 neurons and permit pubertal maturation remain to be clarified.
Xiaoliang, Qiu, Abigail R, Dowling, Joseph S, Marino, Latrice D, Faulkner, Benjamin, Bryant, Jens C, Brüning, Carol F, Elias, Jennifer W, Hill   +7 more
openaire   +2 more sources

A role for GABA agonist in controlling the reproduction of female rats via hypothalamic ghrelin, kisspeptin, and RFRP-3 gene expression [PDF]

The Iranian Journal of Veterinary Science and Technology, 2021
Kisspeptin stimulates gonadotropin releasing hormone (GnRH). The GnRH neurons receive inhibitory inputs from ghrelin, RFamide related peptide-3 (RFRP-3), and gamma-aminobutyric acid (GABA) neurons.
Elaheh Rahimi Rick, Fariba Mahmoudi, Homayoun khazali, Asadollah Asadi, Mahnaz Ghowsi   +4 more
doaj   +1 more source

Sexually dimorphic gene expression and neurite sensitivity to estradiol in fetal arcuate Kiss1 cells [PDF]

, 2020
International audienceKiss1 neurons of the arcuate (ARC) nucleus form an interconnected network of cells that communicate via neurokinin B (encoded by Tac2) and its receptor (encoded by Tacr3) and play key roles in the control of the reproductive axis ...
Poissenot, Kevin, Alfaia, Caroline, Colledge, William, Le Vern, Yves, Robert, Vincent, Guillaume, Daniel, Yeo, Shel-Hwa, Franceschini, Isabelle   +7 more
core   +2 more sources

Chlorobisphenol A activated kisspeptin/GPR54-GnRH neuroendocrine signals through ERα and GPER pathway in neuronal GT1-7 cells

Ecotoxicology and Environmental Safety, 2022
Chlorobisphenol A (ClxBPA) is a kind of novel estrogenic compounds. The present study aims to investigate the effects of three ClxBPA compounds on the kisspeptin/G protein-coupled receptor 54 (GPR54, also named KissR1)-gonadotropin-releasing hormone ...
Bingli Lei, Lanbing Xu, Yaoyao Huang, Yun Liu, Mengjie Yu, Qianqian Tang   +5 more
doaj   +1 more source

Kiss1 and its receptor: molecular characterization and immunolocalization in the hypothalamus and corpus luteum of the buffalo

Animal Biotechnology, 2018
ABSTARCT The neuropeptide kisspeptin (Kp) through its receptor Kiss1r regulates the HPG axis by controlling GnRH release. Since buffalo is a seasonal breeder with problems of delayed puberty and postpartum anestrus, we characterized the Kiss1 and Kiss1r and investigated the immunolocalization in the hypothalamus and corpus luteum (CL). Kiss1 and Kiss1r
Girish Kumar, Mishra, Manas Kumar, Patra, Laishram Kipjen, Singh, Vikramaditya, Upmanyu, Soumendu, Chakravarti, Karikalan, M, Sanjay Kumar, Singh, Goutam Kumar, Das, Harendra, Kumar, Narayanan, Krisnaswami   +9 more
openaire   +2 more sources