Results 71 to 80 of about 1,110,898 (202)

Redundancy in Kiss1 expression safeguards reproduction in the mouse

, 2013
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a prerequisite for puberty and reproduction.
Moriyama, Ryutaro M., Navarro, Victor M., Steiner, Robert A, Seminara, Stephanie B., Popa, Simina M., Concepcion, Tessa L., Clifton, Donald K., Chan, Yee-Ming, Sanz, Elisenda, Yang, Jasmine J., Oakley, Amy E., Caligioni, Claudia S., Lee, In Hae, Palmiter, Richard D., Amieux, Paul S., Cho, Caroline M., Caraty, Alain   +16 more
core   +1 more source

Inactivating KISS1 mutation and hypogonadotropic hypogonadism

, 2012
Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B stimulate GnRH release.
Kotan, Damla, Yuksel, Bilgin, Topaloglu, A Kemal, Millar, Robert, Ozbek, Mehmet, Gurbuz, Fatih, Temiz, Fatih, Erdogan, Seref, Yilmaz, Bertan, Tello, Javier   +9 more
core   +2 more sources

Effects of Fuyou Formula on GnRH Secretion and Related Gene Expression in Treating Precocious Puberty

Frontiers in Pharmacology, 2022
The Fuyou (Fy) formula is an in-hospital preparation consisting of traditional Chinese medicine (TCM) that has been used for treating precocious puberty (PP) for more than 20 years.
Yi Zhang, Ning Sun, Meng Zhang, Meng Zhang, Qian Ding, Qian Ding, Qian Wang, Yuguang Liang, Huan He, Yuxin Yang, Chunyan Guo, Chunyan Guo   +11 more
doaj   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 3-16, August 2026.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Gene structure of the Kiss1 receptor-2 (Kiss1r-2) in the Atlantic halibut: Insights into the evolution and regulation of Kiss1r genes [PDF]

Molecular and Cellular Endocrinology, 2010
Kisspeptin and its receptor, Kiss1r, play an essential role in the control of the onset of puberty in vertebrates. We characterized the cDNA and genomic DNA encoding Kiss1r in Atlantic halibut (Hippoglossus hippoglossus). The 1146bp open reading frame predicts a 381 amino acid protein with high homology to the Kiss1r-2 of other teleost fish ...
Mechaly, Alejandro S., Viñas, Jordi, Murphy, Colleen, Reith, Michael, Piferrer, Francesc   +4 more
openaire   +3 more sources

Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice [PDF]

, 2014
Kisspeptin, encoded by Kiss1, stimulates reproduction and is synthesized in the hypothalamic anteroventral periventricular and arcuate nuclei. Kiss1 is also expressed at lower levels in the medial amygdala (MeA) and bed nucleus of the stria terminalis ...
Lux, Victoria Adela R., Di Giorgio, Noelia Paula, Kauffman, Alexander S., Lux-Lantos, Victoria A., Lux-Lantos, Victoria A, Di Giorgio, Noelia P., Semaan, Sheila J, López, Paula V, Lopez, Paula V., Lopez, Paula Veronica, Semaan, Sheila J., Di Giorgio, Noelia P, Kauffman, Alexander S, Bettler, Bernhard, Libertun, Carlos, Kim, Joshua   +15 more
core   +1 more source

Differential regulation of Kiss1 gene expression by oestradiol in the hypothalamus of the female Damaraland mole-rat, an induced ovulator [PDF]

, 2023
DATA AVAILABILITY : Data will be made available on request.Kisspeptin, a product of the Kiss1 gene is considered a potent stimulator of gonadotropin release, by interacting with its receptor, the G protein-coupled receptor 54.
Bennett, Nigel Charles, Voigt, Cornelia, Gahr, Manfred   +2 more
core   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, Volume 18, Issue 7, Page 862-876, July 2026.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Delayed pubertal onset and prepubertalKiss1expression in female mice lacking centraloestrogen receptor beta [PDF]

Human Molecular Genetics, 2015
Ovarian oestradiol is essential for pubertal maturation and adult physiology of the female reproductive axis. It acts at central and peripheral sites through two main oestrogen receptors (ER) α and β. Here we investigate the role of ERβ on central effects of oestradiol, by generating a mouse line specifically lacking the ERβ gene in neuronal and glial ...
Naule, Lydie, Robert, Vincent, Parmentier, Caroline, Martini, Mariangela, Keller, Matthieu, Cohen-Solal, Martine, Hardin-Pouzet, Helene, Grange-Messent, Valerie, Franceschini, Isabelle, Mhaouty-Kodja, Sakina   +9 more
openaire   +4 more sources

Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period.

PLoS ONE, 2015
Reproduction requires adequate energy stores for parents and offspring to survive. Kiss1 neurons, which are essential for fertility, have the potential to serve as the central sensors of metabolic factors that signal to the reproductive axis the presence
Xiaoliang Qiu, Hoangha Dao, Mengjie Wang, Amelia Heston, Kaitlyn M Garcia, Alisha Sangal, Abigail R Dowling, Latrice D Faulkner, Scott C Molitor, Carol F Elias, Jennifer W Hill   +10 more
doaj   +1 more source