Results 71 to 80 of about 1,354,109 (194)
Immunohistochemical study of KiSS1 and KiSS1R expression in human primary breast cancer: Association with breast cancer receptor status, proliferation markers and clinicopathological features [PDF]
, 2015 Recent studies have raised doubts about the protective role of KiSS1/KiSS1R in breast malignancy progression. However, the role of the KiSS1/KiSS1R system in primary breast cancer remains largely unknown.
Milewski, Robert +4 more
core +1 more source
The Journal of Clinical Endocrinology & Metabolism, 2021 Abstract Context Recent evidence suggests that vasomotor symptoms (VMS) or hot flashes in the postmenopausal reproductive state and polycystic ovary syndrome (PCOS) in the premenopausal reproductive state emanate from the hyperactivity of Kiss1 neurons in the hypothalamic infundibular/arcuate nucleus (
Elizabeth A McCarthy +10 more
openaire +2 more sources
, 2018 Supplemental Material, supplemental_figure_1 for Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells—Potential Pathogenesis of Polycystic Ovary Syndrome by Kai-Lun Hu, Hongcui Zhao, Zheying Min, Yilei He, Tianjie Li, Xiumei ...
Tianjie Li (2885159) +9 more
core +1 more source
The role of KNDy neurons in human reproductive health
Endocrine JournalIn the early 2000s, metastin, an endogenous ligand for G protein-coupled receptor 54 (GPR54), was discovered in human placental extracts. In 2003, GPR54 receptor mutations were found in a family with congenital hypogonadotropic hypogonadism. Metastin was
Aki Oride, Haruhiko Kanasaki
doaj +1 more source
Does kisspeptin exert a local modulatory effect on bovine ovarian steroidogenesis?
Reproduction and Fertility, 2023 Kisspeptin, a hypothalamic neuropeptide encoded by the KISS1 gene, has a pivotal role in promoting gonadotrophin-releasing hormone secretion in mammals.
Dareen Mattar +3 more
doaj +1 more source
Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders [PDF]
Journal of Visualized Experiments, 2011 The kisspeptin receptor (KISS1R) is a G protein-coupled receptor recognized as the trigger of puberty and a regulator of reproductive competence in adulthood (1,2,3). Inactivating mutations in KISS1R identified in patients have been associated with iodiopathic hypogonadotropic hypogonadism (IHH) (1,2) and precocious puberty (4).
Luciana, Madeira da Silva +2 more
openaire +2 more sources
Kiss1-PgrKO mice have impaired kisspeptin-mediated GnRH release.
, 2016 A. Serum LH before and after stimulation of kisspeptin neurons by exogenous administration of estradiol in 6-8-month-old ovariectomized WT and Kiss1-PgrKO mice (n = 3); a represent statistical difference between WT, and b represents statistical ...
Andrew Wolfe (703417) +9 more
core +1 more source
Frontiers in Pharmacology, 2022 The Fuyou (Fy) formula is an in-hospital preparation consisting of traditional Chinese medicine (TCM) that has been used for treating precocious puberty (PP) for more than 20 years.
Yi Zhang +11 more
doaj +1 more source
Sexually dimorphic expression of hypothalamic estrogen receptors α and β and kiss1 in neonatal male and female rats [PDF]
Journal of Comparative Neurology, 2011 AbstractRelease of gonadotropins in adult rodents is sex specific and dependent upon kisspeptin (Kiss1) neurons. This crucial pathway within the hypothalamic‐pituitary‐gonadal (HPG) axis is profoundly influenced by neonatal estrogens, which induce a male‐like phenotype.
Jinyan, Cao, Heather B, Patisaul
openaire +2 more sources
Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.Abstract To describe clinical presentation and genetic findings in a cohort of infants with congenital hypogonadotropic hypogonadism (CHH) diagnosed before 2 years of age. From a large cohort of patients who underwent next‐generation sequencing (NGS) for CHH between 2019 and 2025, we identified all patients tested at ≤2 years of age.
Karine Aouchiche +16 more
wiley +1 more source