Results 81 to 90 of about 1,110,898 (202)

Pubertal development and hypothalamic–pituitary–gonadal axis are altered in male mice lacking Mecp2

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Ana Martín‐Sánchez, Daniela Jiménez‐Díaz, Rafael Esteve‐Pérez, Alexandru Vasile‐Tudorache, Jordan E. Read, Sasha R. Howard, Carmen Agustín‐Pavón   +6 more
wiley   +1 more source

Regulation of Kiss1 and Dynorphin Gene Expression in the Murine Brain by Classical and Nonclassical Estrogen Receptor Pathways [PDF]

The Journal of Neuroscience, 2009
Kisspeptin is a product of the Kiss1 gene and is expressed in the forebrain. Neurons that express Kiss1 play a crucial role in the regulation of pituitary luteinizing hormone secretion and reproduction.
Michelle L, Gottsch, Víctor M, Navarro, Zhen, Zhao, Christine, Glidewell-Kenney, Jeffrey, Weiss, J Larry, Jameson, Donald K, Clifton, Jon E, Levine, Robert A, Steiner   +8 more
openaire   +2 more sources

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof‐of‐Concept Synthesis of Landscape‐Level Regulation

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter   +3 more
wiley   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

Role of Kiss1 in serotonergic modulation in the zebrafish

, 2017
KISS1/Kiss1 gene produces a neuropeptide, kisspeptin with the ability to activate its G-protein coupled receptor, GPR54 (Kiss-R), which is involved in the control of vertebrate reproduction.
Nathan , Fatima Megala (3770320)
core   +1 more source

Estrogen increases KISS1 expression in newly generated immortalized KISS1-expressing cell line derived from goat preoptic area

The Journal of Reproduction and Development, 2020
Kisspeptin neurons located in the hypothalamic preoptic area (POA) are suggested to be responsible for the induction of the gonadotropin-releasing hormone (GnRH) surge and the following luteinizing hormone (LH) surge to regulate female mammals’ ovulation.
Yukina OSHIMO, Arisa MUNETOMO, Fumie MAGATA, Yuta SUETOMI, Shuhei SONODA, Yukari TAKEUCHI, Hiroko TSUKAMURA, Satoshi OHKURA, Fuko MATSUDA   +8 more
doaj   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Investigation of KISS1/KISS1R gene expression and KISS1 rs5780218 polymorphism in somatotropinomas nonfunctioning pituitary adenomas

, 2018
Apesar de amplamente estudados, os mecanismos envolvidos no processo de transformação neoplásica das células hipofisárias e na progressão desses tumores permanecem, ainda, pouco esclarecidos.
Amorim, Paulo Vinícius Gonçalves Holanda
core   +1 more source

Tooth Decay Promotes Senescence in Dental Pulp Stem Cells, Modifying Their Biological and Proteomic Profiles

Journal of Cellular Physiology, Volume 241, Issue 4, April 2026.
ABSTRACT Dental caries is a prevalent oral health problem that significantly reduces an individual's quality of life; although, it can be effectively managed through restorative treatments. Even in cases where the caries does not reach the pulp, released microbial products from the lesion can still penetrate the pulp chamber, potentially inducing ...
Sebahat Melike Durukan, Mustafa Burak Acar, Banu Çiçek Tez, Ahmet Şimşek, Sura Hilal Ahmed Al‐Sammarrie, Zeynep Günaydın, Melis Güzel, Başak Bilge Süer, Şerife Ayaz Güner, Hüseyin Güner, Nicola Alessio, Kemal Erdem Başaran, Zeynep Burçin Gönen, Servet Özcan   +13 more
wiley   +1 more source

Co‐expression of the calcitonin receptor gene in the hypothalamic kisspeptin neurons in female rats

Reproductive Medicine and Biology, 2018
Purpose Hypothalamic kisspeptin neurons are considered to play a critical role in regulating mammalian reproduction and integrating humoral and neuronal inputs that control gonadotropin‐releasing hormone (GnRH)/gonadotropin release.
Assadullah, Nahoko Ieda, Narumi Kawai, Hirotaka Ishii, Kunio Ihara, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura   +7 more
doaj   +1 more source