Results 81 to 90 of about 1,354,109 (194)
Gene structure of the Kiss1 receptor-2 (Kiss1r-2) in the Atlantic halibut: Insights into the evolution and regulation of Kiss1r genes [PDF]
Molecular and Cellular Endocrinology, 2010 Kisspeptin and its receptor, Kiss1r, play an essential role in the control of the onset of puberty in vertebrates. We characterized the cDNA and genomic DNA encoding Kiss1r in Atlantic halibut (Hippoglossus hippoglossus). The 1146bp open reading frame predicts a 381 amino acid protein with high homology to the Kiss1r-2 of other teleost fish ...
Mechaly, Alejandro S. +4 more
openaire +3 more sources
Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period.
PLoS ONE, 2015 Reproduction requires adequate energy stores for parents and offspring to survive. Kiss1 neurons, which are essential for fertility, have the potential to serve as the central sensors of metabolic factors that signal to the reproductive axis the presence
Xiaoliang Qiu +10 more
doaj +1 more source
Delayed pubertal onset and prepubertalKiss1expression in female mice lacking centraloestrogen receptor beta [PDF]
Human Molecular Genetics, 2015 Ovarian oestradiol is essential for pubertal maturation and adult physiology of the female reproductive axis. It acts at central and peripheral sites through two main oestrogen receptors (ER) α and β. Here we investigate the role of ERβ on central effects of oestradiol, by generating a mouse line specifically lacking the ERβ gene in neuronal and glial ...
Naule, Lydie +9 more
openaire +4 more sources
Regulation of Kiss1 and Dynorphin Gene Expression in the Murine Brain by Classical and Nonclassical Estrogen Receptor Pathways [PDF]
The Journal of Neuroscience, 2009 Kisspeptin is a product of the Kiss1 gene and is expressed in the forebrain. Neurons that express Kiss1 play a crucial role in the regulation of pituitary luteinizing hormone secretion and reproduction.
Michelle L, Gottsch +8 more
openaire +2 more sources
The Journal of Reproduction and Development, 2020 Kisspeptin neurons located in the hypothalamic preoptic area (POA) are suggested to be responsible for the induction of the gonadotropin-releasing hormone (GnRH) surge and the following luteinizing hormone (LH) surge to regulate female mammals’ ovulation.
Yukina OSHIMO +8 more
doaj +1 more source
Maternal and infant gut microbiome
iMeta, Volume 5, Issue 4, August 2026.The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang +25 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.Of 175 Australian children with fetal alcohol spectrum disorder (FASD), 90% had genetic testing, and of those, 24% had a rare copy number variant (CNV). Genetic testing supports the FASD diagnostic process and may reveal additional diagnoses or sources of genetic vulnerability to FASD.
Suzy Byrnes +2 more
wiley +1 more source
Co‐expression of the calcitonin receptor gene in the hypothalamic kisspeptin neurons in female rats
Reproductive Medicine and Biology, 2018 Purpose Hypothalamic kisspeptin neurons are considered to play a critical role in regulating mammalian reproduction and integrating humoral and neuronal inputs that control gonadotropin‐releasing hormone (GnRH)/gonadotropin release.
Assadullah +7 more
doaj +1 more source
, 2022 The hypothalamic kisspeptin/KISS1 receptor system is essential for puberty onset and reproductive development. Although serum kisspeptin might be associated with puberty, its levels, according to developmental stage, and its origin still remain unclear ...
Ji Young Eom (14118657) +7 more
core +1 more source
Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology
Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 3-16, August 2026.ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib +3 more
wiley +1 more source