Results 61 to 70 of about 1,354,109 (194)

Haploinsufficiency in the Prometastasis Kiss1 Receptor Gpr54 Delays Breast Tumor Initiation, Progression, and Lung Metastasis [PDF]

Cancer Research, 2011
Abstract Activation of KISS1 receptor (KISS1R or GPR54) by its ligands (Kisspeptins) regulates a diverse function both in normal physiology and pathophysiology. In cancer, KISS1R has been implicated in tumor angiogenesis and metastasis, but a broader evaluation of KISS1R in tumorigenesis and tumor progression is yet to be conducted.
Sung-Gook, Cho, Ying, Wang, Melissa, Rodriguez, Kunrong, Tan, Wenzheng, Zhang, Jian, Luo, Dali, Li, Mingyao, Liu   +7 more
openaire   +2 more sources

Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.

, 2011
Kisspeptin (Kiss1) and neurokinin B (NKB) (encoded by the Kiss1 and Tac2 genes, respectively) are indispensable for reproduction. In the female of many species, Kiss1 neurons in the arcuate nucleus (ARC) coexpress dynorphin A and NKB.
Ronnekleiv, O K, Clifton, D K, Alreja, M, D. García-Galiano, D. K. Clifton, M. Alreja, Tena, Sempere M, L. Pinilla, Garcia, Galiano D, S. J. Hobbs, M. L. Gottsch, O. K. Ronnekleiv, M. Tena-Sempere, Dearth, A, Braun, R E, A. Dearth, Wu, M, Palmiter, R D, Gottsch, M L, R. A. Steiner, M. Wu, Bosch, M A, M. A. Bosch, R. E. Braun, Pinilla, L, Steiner, R A, Navarro, V M, V. M. Navarro, R. D. Palmiter, Hobbs, S J   +29 more
core   +2 more sources

The differential expression of Kiss1, MMP9 and angiogenic regulators across the feto-maternal interface of healthy human pregnancies: implications for trophoblast invasion and vessel development. [PDF]

PLoS ONE, 2013
Genes involved in invasion of trophoblast cells and angiogenesis are crucial in determining pregnancy outcome. We therefore studied expression profiles of these genes in both fetal and maternal tissues to enhance our understanding of feto-maternal ...
Mushi Matjila, Robert Millar, Zephne van der Spuy, Arieh Katz   +3 more
doaj   +1 more source

Association of the KISS1, LIN28B, VDR and ERα gene polymorphisms with early and fast puberty in Chinese girls

Gynecological Endocrinology, 2023
Objectives To explore the association of KISS1, LIN28B, vitamin D receptor (VDR), and estrogen receptor α (ERα) gene polymorphisms and the risk of early with fast puberty (EFP) risk, and with hormone levels in EFP cases, in Chinese girls.Methods The ...
Yunwei Li, Huifeng Zhang, Qiang Li, Xinwei Huang, Xiangyang Kong   +4 more
doaj   +1 more source

Duplicated Kiss1 receptor genes in zebrafish: distinct gene expression patterns, different ligand selectivity, and a novel nuclear isoform with transactivating activity [PDF]

, 2012
The kisspeptin (Kiss1) and Kiss1 receptor (Kiss1r) pathway plays a central role in the neuroendocrine control of reproduction. In contrast to humans and mammals that have a single Kiss1 gene and a single Kiss1r gene, multiple Kiss ligand and receptor ...
Duan, Cunming, Onuma, Takeshi A.
core   +1 more source

Investigation of the relationship between prolactin and infertility by expression levels of kisspeptin (KISS1), KISS1 receptor, neurokinin (NK), NK receptor genes

The European Research Journal
Objectives: Prolactin level, which rises in the blood during pregnancy and after birth, plays a role in physiological events such as metabolism and reproduction. Increased blood levels of prolactin lead to various disorders. The most important of these are amenorrhea/galactorrhea and disruption of ovulation. Disruption of ovulation is a serious problem
Eylül Akbal, Mehmet Bertan Yılmaz
openaire   +2 more sources

Anteroventral Periventricular Kiss1 Gene Expression is Regulated by Estradiol through Estrogen Response Elements [PDF]

, 2020
In females, estrogen signaling is necessary for coordinating ovulation and the menstrual cycle. KISS1, a gene expressed by kisspeptin neurons and critical for reproduction, is positively and negatively regulated by 17β-estradiol (E2), an endogenous ...
Chou, Teresa
core   +1 more source

Role of Kiss1 in serotonergic modulation in the zebrafish

, 2017
KISS1/Kiss1 gene produces a neuropeptide, kisspeptin with the ability to activate its G-protein coupled receptor, GPR54 (Kiss-R), which is involved in the control of vertebrate reproduction.
Nathan , Fatima Megala (3770320)
core   +1 more source

Developmental Profile and Sexually Dimorphic Expression of Kiss1 and Kiss1r in the Fetal Mouse Brain

Frontiers in Endocrinology, 2013
The hypothalamic-pituitary-gonadal axis (HPG) is a complex neuroendocrine circuit involving multiple levels of regulation. Kisspeptin neurons play essential roles in controlling the HPG axis from the perspectives of puberty onset, oscillations of ...
John Gabriel Knoll, Colin eClay, Gerrit eBouma, Timothy eHenion, Gerald eSchwarting, Robert eMillar, Stuart eTobet   +6 more
doaj   +1 more source

New Evidence for the Existence of Two Kiss/Kissr Systems in a Flatfish Species, the Turbot (Scophthalmus maximus), and Stimulatory Effects on Gonadotropin Gene Expression

Frontiers in Endocrinology, 2022
Seasonal reproduction is generally controlled by the hypothalamus-pituitary-gonadal (HPG) axis in fish. Previous studies have demonstrated that the kisspeptin (Kiss)/kisspeptin receptor (Kissr) system, a positive regulator of the HPG axis, mediates the ...
Chunyan Zhao, Chunyan Zhao, Chunyan Zhao, Bin Wang, Yifan Liu, Yifan Liu, Yifan Liu, Chengcheng Feng, Chengcheng Feng, Shihong Xu, Shihong Xu, Wenqi Wang, Qinghua Liu, Qinghua Liu, Jun Li, Jun Li, Jun Li   +16 more
doaj   +1 more source