Results 91 to 100 of about 1,110,898 (202)

Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Cleisla Souza Oliveira, Maria Clara Pascoal Santos Alvarez, Natália Panhoca Rodrigues, Jorge Lopez‐Tello, Amanda N. Sferruzzi‐Perri, Rogéria Serakides, Juneo Freitas Silva   +9 more
wiley   +1 more source

Sexually dimorphic gene expression and neurite sensitivity to estradiol in fetal arcuate Kiss1 cells [PDF]

, 2020
International audienceKiss1 neurons of the arcuate (ARC) nucleus form an interconnected network of cells that communicate via neurokinin B (encoded by Tac2) and its receptor (encoded by Tacr3) and play key roles in the control of the reproductive axis ...
Poissenot, Kevin, Alfaia, Caroline, Colledge, William, Le Vern, Yves, Robert, Vincent, Guillaume, Daniel, Yeo, Shel-Hwa, Franceschini, Isabelle   +7 more
core   +2 more sources

Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse. [PDF]

, 2016
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in the regulation of the mammalian reproductive axis. Kiss1 neurones are found in two locations in the rodent hypothalamus: one in the arcuate nucleus (ARC) and another in ...
Morris, PG, Sinnett-Smith, LC, Schacker, M, Colledge, W. H., Kyle, V, Jackman, S, Yeo, SH, Chen, C   +7 more
core   +3 more sources

The Expression of Kisspeptins and Matrix Metalloproteinases in Extragenital Endometriosis

Biomedicines
Endometriosis is characterized by a condition where endometrial tissue grows outside the uterine cavity. The mechanisms of endometrium growth during endometriosis might be similar to the development of a tumor.
Tatiana Kleimenova, Victoria Polyakova, Natalia Linkova, Anna Drobintseva, Dmitriy Medvedev, Alexander Krasichkov   +5 more
doaj   +1 more source

Does kisspeptin signalling have a role in the testes?

Frontiers in Endocrinology, 2013
Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that regulate the mammalian reproductive axis by a central action in the hypothalamus to stimulate GnRH release. Kisspeptins and their receptor (Gpr54 also called Kiss1r) are
Mei eHua, Joanne eDoran, Victoria eKyle, Shel-Hwa eYeo, William Henry Colledge   +4 more
doaj   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

AVPV Kiss1 neuron-specific knockdown of purinergic P2X2 receptor suppresses LH surge and ovulation in Kiss1-Cre rats

The Journal of Reproduction and Development
Ovulation disorders are a major cause of low pregnancy rates and infertility in humans and livestock. Kisspeptin neurons located in the anteroventral periventricular nucleus (AVPV) are responsible for the generation of the gonadotropin-releasing hormone (
Safiullah HAZIM, Shunsuke SEKI, Ryoya YABUSHITA, Mayuko NAGAE, Hitomi TSUCHIDA, Masumi HIRABAYASHI, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Naoko INOUE   +8 more
doaj   +1 more source

Eel Kisspeptins: Identification, Functional Activity, and Inhibition on both Pituitary LH and GnRH Receptor Expression

Frontiers in Endocrinology, 2018
The European eel (Anguilla anguilla) presents a blockade of sexual maturation at a prepubertal stage due to a deficient production of gonadotropins.
Jérémy Pasquier, Anne-Gaëlle Lafont, Florian Denis, Benjamin Lefranc, Christophe Dubessy, Antonio Moreno-Herrera, Antonio Moreno-Herrera, Hubert Vaudry, Jérôme Leprince, Sylvie Dufour, Karine Rousseau   +10 more
doaj   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, Volume 9, Issue 3, Page 453-461, March 2026.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

CHARACTERIZATION OF Kiss1 NEURONS USING TRANSGENIC MOUSE MODELS

, 2011
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism.
MARGATHO, L. O., ROVINSKY, S., GAUTRON, L., CRAVO, R. M., FRAZAO, R., BOOKOUT, A. L., DONATO JR., J., ZIGMAN, J. M., ELIAS, C. F., OSBORNE-LAWRENCE, S., ATKIN, S., LEE, C. E.   +11 more
core   +1 more source