Results 91 to 100 of about 1,354,109 (194)

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, Volume 18, Issue 7, Page 862-876, July 2026.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Does kisspeptin signalling have a role in the testes?

Frontiers in Endocrinology, 2013
Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that regulate the mammalian reproductive axis by a central action in the hypothalamus to stimulate GnRH release. Kisspeptins and their receptor (Gpr54 also called Kiss1r) are
Mei eHua, Joanne eDoran, Victoria eKyle, Shel-Hwa eYeo, William Henry Colledge   +4 more
doaj   +1 more source

Liver Receptor Homolog-1 Regulates Kisspeptin Expression in the Arcuate Nucleus to Promote Reproductive Axis Function

, 2014
The timing of ovulation in mammals is set by a complex hypothalamic pituitary neuroendocrine axis. Kisspeptin neurons in the arcuate nucleus (Arc) are thought to secrete kisspeptin (Kiss1) to stimulate the release of follicle stimulating hormone (FSH ...
Atkin, Stan Dean
core   +3 more sources

Pubertal development and hypothalamic–pituitary–gonadal axis are altered in male mice lacking Mecp2

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Ana Martín‐Sánchez, Daniela Jiménez‐Díaz, Rafael Esteve‐Pérez, Alexandru Vasile‐Tudorache, Jordan E. Read, Sasha R. Howard, Carmen Agustín‐Pavón   +6 more
wiley   +1 more source

CHARACTERIZATION OF Kiss1 NEURONS USING TRANSGENIC MOUSE MODELS

, 2011
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism.
MARGATHO, L. O., ROVINSKY, S., GAUTRON, L., CRAVO, R. M., FRAZAO, R., BOOKOUT, A. L., DONATO JR., J., ZIGMAN, J. M., ELIAS, C. F., OSBORNE-LAWRENCE, S., ATKIN, S., LEE, C. E.   +11 more
core   +1 more source

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof‐of‐Concept Synthesis of Landscape‐Level Regulation

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter   +3 more
wiley   +1 more source

The Expression of Kisspeptins and Matrix Metalloproteinases in Extragenital Endometriosis

Biomedicines
Endometriosis is characterized by a condition where endometrial tissue grows outside the uterine cavity. The mechanisms of endometrium growth during endometriosis might be similar to the development of a tumor.
Tatiana Kleimenova, Victoria Polyakova, Natalia Linkova, Anna Drobintseva, Dmitriy Medvedev, Alexander Krasichkov   +5 more
doaj   +1 more source

Eel Kisspeptins: Identification, Functional Activity, and Inhibition on both Pituitary LH and GnRH Receptor Expression

Frontiers in Endocrinology, 2018
The European eel (Anguilla anguilla) presents a blockade of sexual maturation at a prepubertal stage due to a deficient production of gonadotropins.
Jérémy Pasquier, Anne-Gaëlle Lafont, Florian Denis, Benjamin Lefranc, Christophe Dubessy, Antonio Moreno-Herrera, Antonio Moreno-Herrera, Hubert Vaudry, Jérôme Leprince, Sylvie Dufour, Karine Rousseau   +10 more
doaj   +1 more source

Regulation of Kiss1 Expression by Sex Steroids in the Amygdala of the Rat and Mouse

, 2011
Kisspeptin (encoded by the Kiss1 gene) is an important regulator of reproduction. In rodents, Kiss1 is expressed in two hypothalamic regions, the arcuate nucleus and anteroventral periventricular/ periventricular continuum, where it is regulated by sex ...
Donald K. Clifton, Alexander S. Kauffman, Sheila J. Semaan, Sangeeta Dhamija, Robert A. Steiner, Joshua Kim   +5 more
core   +1 more source

Role of amygdala kisspeptin in pubertal timing in female rats.

PLoS ONE, 2017
To investigate the mechanism by which maternal obesity disrupts reproductive function in offspring, we examined Kiss1 expression in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV) nuclei, and posterodorsal medial amygdala (MePD ...
Daniel A Adekunbi, Xiao Feng Li, Shengyun Li, Olufeyi A Adegoke, Bolanle O Iranloye, Ayodele O Morakinyo, Stafford L Lightman, Paul D Taylor, Lucilla Poston, Kevin T O'Byrne   +9 more
doaj   +1 more source