EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression
Cell Communication and Signaling, 2021 Background During pregnancy, trophoblast cell invasion needs to be finely controlled. Aberrant trophoblast cell invasion is associated with placental diseases.
Lanlan Fang +7 more
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The Kisspeptin System in Male Reproduction
Endocrines, 2022 The kisspeptin system includes the cleavage products Kiss1 precursor and kisspeptin receptor (Kiss1R). It was originally discovered and studied in cancer metastasis, but the identification of KISS1/KISS1R gene mutations causing hypogonadotropic ...
Rosaria Meccariello
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Altered placental expression of kisspeptin and its receptor in pre-eclampsia [PDF]
, 2012 Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy.
Williams, Paula Juliet +3 more
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Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). [PDF]
PLoS ONE, 2014 Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals.
Yali Zhao +4 more
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Kisspeptin Stimulation of Prolactin Secretion Requires Kiss1 Receptor but Not in Tuberoinfundibular Dopaminergic Neurons [PDF]
Endocrinology, 2019 Abstract Kisspeptin has been shown to stimulate prolactin secretion. We investigated whether kisspeptin acts through the Kiss1 receptor (Kiss1r) to regulate dopamine and prolactin. Initially, we evaluated prolactin response in a Kiss1r-deficient mouse line, in which Kiss1r had been knocked into GnRH neurons (Kiss1r−/−R ...
Nayara S S Aquino +8 more
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Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species
Frontiers in Endocrinology, 2018 Kisspeptin is a neuropeptide, encoded by kisspeptin 1 (KISS1)/Kiss1 gene, which primarily acts as the regulator of reproductive functions via its receptor, kisspeptin receptor (KissR) in vertebrates.
Satoshi Ogawa, Ishwar S. Parhar
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Journal of Ovarian Research, 2023 Background Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Electroacupuncture (EA) can effectively improve hyperandrogenism and increase ovulation frequency in patients with PCOS.
Ge Xu +6 more
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The Journal of Reproduction and Development, 2022 Reproductive function is suppressed during lactation owing to the suckling-induced suppression of the kisspeptin gene (Kiss1) expression in the arcuate nucleus (ARC) and subsequent suppression of luteinizing hormone (LH) release.
Arisa SUGIMOTO +5 more
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Role of Kisspeptin-GPR54 system in regulation of reproductive functions in human and other mammals
Pakistan Journal of Pharmaceutical Sciences, 2021 Kisspeptin is a 54- amino acid peptide that acts as a ligand of a receptor called GPR54 which is basically a transmembrane receptor that spins seven times across the cell membrane and coupled with G-protein.
Ikram Ilahi, Taqweem Ul Haq
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Sex‐specific expression of estrogen receptors α and β and Kiss1 in the postnatal rat amygdala [PDF]
Journal of Comparative Neurology, 2012 AbstractThe rodent amygdaloid complex is composed of numerous subnuclei important for the sex‐specific regulation of sociosexual behavior. Although estrogen receptors (ERs) are critical for organizing functional and cytoarchitectural sex differences in these subnuclei, a detailed developmental profile of ER expression in the amygdaloid complex is not ...
Jinyan, Cao, Heather B, Patisaul
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