Results 31 to 40 of about 1,354,109 (194)
Endokrynologia Polska, 2021 Pituitary neuroendocrine tumours (PitNETs), traditionally designated as pituitary adenomas, show elatively frequent invasive growth with exceptional metastatic potential, the causes of which are not entirely elucidated. Kisspeptins, which perform their activity through KISS1 receptor (KISS1R), are recognised as metastatic suppressors in many malignant ...
Milena, Mihajlovic +13 more
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Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 [PDF]
Proceedings of the National Academy of Sciences, 2003 Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
Nicolas, de Roux +5 more
openaire +4 more sources
Upregulation of Kiss-1 and Gpr54 Genes Expression in Pituitary of Male Rats Following the Central Administration of Neuropeptide Y [PDF]
International Journal of Basic Science in Medicine, 2019 Introduction: The neuropeptide Y (NPY) in the neural circuits of the hypothalamus has a stimulating effect on reproductive activities in mammals. Kisspeptin (KiSS1) is a quintessential neurotransmitter in the reproductive axis which directly stimulates ...
Vahid Azizi +3 more
doaj +1 more source
Frontiers in Oncology, 2023 Metastatic dissemination is still one of the major causes of death of melanoma’s patients. KiSS1 is a metastasis suppressor originally identified in melanoma cells, known to play an important physiological role in mammals’ development and puberty. It has
Carlotta Guzzetti +7 more
doaj +1 more source
Shift in Kiss1 Cell Activity Requires Estrogen Receptor α [PDF]
The Journal of Neuroscience, 2013 Reproductive function requires timely secretion of gonadotropin-releasing hormone, which is controlled by a complex excitatory/inhibitory network influenced by sex steroids. Kiss1 neurons are fundamental players in this network, but it is currently unclear whether different conditions of circulating sex steroids directly alter ...
Renata, Frazão +8 more
openaire +2 more sources
Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells [PDF]
Human Reproduction, 2014 Are neurokinin B (NKB), NK3 receptor (NK3R), kisspeptin (KISS1) and kisspeptin receptor (KISS1R) expressed in human ovarian granulosa cells?The NKB/NK3R and kisspeptin/KISS1R systems are co-expressed and functionally active in ovarian granulosa cells.The NKB/NK3R and KISS1/KISS1R systems are essential for reproduction.
J, García-Ortega +9 more
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Indian Journal of Animal Sciences, 2022 In the past decade, kisspeptin research was primarily focussed on the regulation of GnRH release in hypothalamus. Present study was designed to explore the expression of extra-hypothalamic kisspeptinergic (Kiss1- Kiss1r) system in the follicular ...
Girish Kumar Mishra +10 more
doaj +1 more source
Differential activation of kiss receptors by Kiss1 and Kiss2 peptides in the sea bass [PDF]
Reproduction, 2015 Abstract Two forms of kiss gene (kiss1 and kiss2) have been described in the teleost sea bass. This study assesses the cloning and characterization of two Kiss receptor genes, namely kissr2 and kissr3 (known as gpr54-1b and gpr54-2b, respectively), and their signal transduction pathways in response to Kiss1 and Kiss2 peptides ...
Felip, Alicia +3 more
openaire +4 more sources
G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance. [PDF]
Sci Rep, 2017 AbstractTriple-negative breast cancer (TNBC) lacks the expression of estrogen receptor α, progesterone receptor and human epidermal growth factor receptor 2 (HER2). TNBC patients lack targeted therapies, as they fail to respond to endocrine and anti-HER2 therapy.
Blake A +7 more
europepmc +5 more sources
Frontiers in Endocrinology, 2023 IntroductionMale reproduction is under the control of the hypothalamus–pituitary–gonadal (HPG) axis. The endocannabinoid system (ECS) and the kisspeptin system (KS) are two major signaling systems in the central and peripheral control of reproduction ...
Marianna Marino +14 more
doaj +1 more source