Results 21 to 30 of about 1,110,898 (202)

The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease. [PDF]

PLoS One, 2016
Multiple myeloma is one of the most common hematological diseases and is characterized by an aberrant proliferation of plasma cells within the bone marrow. As a result of crosstalk between cancer cells and the bone microenvironment, bone homeostasis is disrupted leading to osteolytic lesions and poor prognosis. Current diagnostic strategies for myeloma
Dotterweich J, Tower RJ, Brandl A, Müller M, Hofbauer LC, Beilhack A, Ebert R, Glüer CC, Tiwari S, Schütze N, Jakob F.   +10 more
europepmc   +6 more sources

Kiss1 receptor knockout exacerbates airway hyperresponsiveness and remodeling in a mouse model of allergic asthma. [PDF]

Respir Res
In asthma, sex-steroids signaling is recognized as a critical regulator of disease pathophysiology. However, the paradoxical role of sex-steroids, especially estrogen, suggests that an upstream mechanism or even independent of estrogen plays an important role in regulating asthma pathophysiology.
Ambhore NS, Balraj P, Kumar A, Reza MI, Ramakrishnan YS, Tesch J, Lohana S, Sathish V.   +7 more
europepmc   +4 more sources

Kiss1 and Kiss1 receptor expression in the rhesus monkey testis: a possible local regulator of testicular function

Open Life Sciences, 2013
Abstract
Tariq Amna, Shahab Muhammad, Clarke Iain, Pereira Alda, Smith Jeremy, Khan Saeed-ul-Hasan, Sultan Javeria, Javed Sehrish, Anwar Tayyaba   +8 more
doaj   +2 more sources

Expression of kisspeptin and KISS1 receptor in pituitary neuroendocrine tumours — an immunohistochemical study

Endokrynologia Polska, 2021
Pituitary neuroendocrine tumours (PitNETs), traditionally designated as pituitary adenomas, show elatively frequent invasive growth with exceptional metastatic potential, the causes of which are not entirely elucidated. Kisspeptins, which perform their activity through KISS1 receptor (KISS1R), are recognised as metastatic suppressors in many malignant ...
Milena, Mihajlovic, Sandra, Pekic, Mirjana, Doknic, Marko, Stojanovic, Dragana, Miljic, Ivan, Soldatovic, Tatjana, Vukotic, Tijana, Janev, Sanja, Cirovic, Tatjana, Terzic, Savo, Raicevic, Milica, Skender-Gazibara, Vera, Popovic, Emilija, Manojlovic-Gacic   +13 more
openaire   +3 more sources

Shift in Kiss1 Cell Activity Requires Estrogen Receptor α [PDF]

The Journal of Neuroscience, 2013
Reproductive function requires timely secretion of gonadotropin-releasing hormone, which is controlled by a complex excitatory/inhibitory network influenced by sex steroids. Kiss1 neurons are fundamental players in this network, but it is currently unclear whether different conditions of circulating sex steroids directly alter Kiss1 neuronal activity ...
Renata, Frazão, Roberta M, Cravo, Jose, Donato, Dhirender V, Ratra, Deborah J, Clegg, Joel K, Elmquist, Jeffrey M, Zigman, Kevin W, Williams, Carol F, Elias   +8 more
openaire   +2 more sources

Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells [PDF]

Human Reproduction, 2014
Are neurokinin B (NKB), NK3 receptor (NK3R), kisspeptin (KISS1) and kisspeptin receptor (KISS1R) expressed in human ovarian granulosa cells?The NKB/NK3R and kisspeptin/KISS1R systems are co-expressed and functionally active in ovarian granulosa cells.The NKB/NK3R and KISS1/KISS1R systems are essential for reproduction.
J, García-Ortega, F M, Pinto, M, Fernández-Sánchez, N, Prados, A, Cejudo-Román, T A, Almeida, M, Hernández, M, Romero, M, Tena-Sempere, L, Candenas   +9 more
openaire   +2 more sources

Relative expression profile of Kisspeptin (Kiss1-Kiss1r) and gonadotrophin receptor in the ovarian follicular tissue and their association in the Buffalo (Bubalus bubalis)

Indian Journal of Animal Sciences, 2022
In the past decade, kisspeptin research was primarily focussed on the regulation of GnRH release in hypothalamus. Present study was designed to explore the expression of extra-hypothalamic kisspeptinergic (Kiss1- Kiss1r) system in the follicular ...
Girish Kumar Mishra, Manas Patra Kumar, Laishram Kipjen Singh, Vikramaditya Upmanyu, Soumendu Chakravarti, Mathesh Karikalan, Manjit Panigrahi, Sanjay Kumar Singh, Goutam Kumar Das, Krishnaswamy Narayanan, Harendra Kumar   +10 more
doaj   +1 more source

Serum kisspeptin levels mainly depend on ovarian expression of Kiss1 mRNA in female rats

Frontiers in Physiology, 2022
The hypothalamic kisspeptin/KISS1 receptor system is essential for puberty onset and reproductive development. Although serum kisspeptin might be associated with puberty, its levels, according to developmental stage, and its origin still remain unclear ...
Ahreum Kwon, Ji Young Eom, Woo Jung Lee, Han Saem Choi, Kyungchul Song, Junghwan Suh, Hyun Wook Chae, Ho-Seong Kim   +7 more
doaj   +1 more source

Differential activation of kiss receptors by Kiss1 and Kiss2 peptides in the sea bass [PDF]

Reproduction, 2015
Abstract Two forms of kiss gene (kiss1 and kiss2) have been described in the teleost sea bass. This study assesses the cloning and characterization of two Kiss receptor genes, namely kissr2 and kissr3 (known as gpr54-1b and gpr54-2b, respectively), and their signal transduction pathways in response to Kiss1 and Kiss2 peptides ...
Felip, Alicia, Espigares, F., Zanuy, Silvia, Gómez, Ana   +3 more
openaire   +4 more sources

The interplay between kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproduction in vivo

Frontiers in Endocrinology, 2023
IntroductionMale reproduction is under the control of the hypothalamus–pituitary–gonadal (HPG) axis. The endocannabinoid system (ECS) and the kisspeptin system (KS) are two major signaling systems in the central and peripheral control of reproduction ...
Marianna Marino, Raffaella D’Auria, Elena Mele, Grazia Maria Giovanna Pastorino, Grazia Maria Giovanna Pastorino, Paola Di Pietro, Stefania D’Angelo, Natalia Della Rocca, Francesca Felicia Operto, Carmine Vecchione, Silvia Fasano, Riccardo Pierantoni, Andrea Viggiano, Rosaria Meccariello, Antonietta Santoro   +14 more
doaj   +1 more source