Results 21 to 30 of about 1,354,109 (194)

AVPV Kiss1 neuron-specific knockdown of purinergic P2X2 receptor suppresses LH surge and ovulation in Kiss1-Cre rats

The Journal of Reproduction and Development
Ovulation disorders are a major cause of low pregnancy rates and infertility in humans and livestock. Kisspeptin neurons located in the anteroventral periventricular nucleus (AVPV) are responsible for the generation of the gonadotropin-releasing hormone (
Safiullah HAZIM, Shunsuke SEKI, Ryoya YABUSHITA, Mayuko NAGAE, Hitomi TSUCHIDA, Masumi HIRABAYASHI, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Naoko INOUE   +8 more
doaj   +3 more sources

Evaluation of KISS1 Receptor Gene Expression in Egyptian Female Patients with Breast Cancer. [PDF]

Asian Pac J Cancer Prev, 2022
Breast cancer is the second most common cancer in the world. Many metastasis suppressor genes were identified, including the KISS1 gene which encodes for a 145 amino acid protein (kisspeptin-145), which undergoes proteolytic cleavage resulting in kisspeptin-14, -13 and -10. All of these proteins can activate KISS1 receptor (KISS1R).
Gomaa SH, Zaki MA, Sultan MH, Sultan MH, Dwedar FI, Elzain Zidan EH.   +5 more
europepmc   +3 more sources

Effect of social isolation and kisspeptin analogues (KS6 and KS10) on the expression of KISS1, KISS2, and their receptors in danio rerio

Research Results in Pharmacology
Introduction: The kisspeptin system regulates both reproductive and stress-related neuroendocrine functions. In zebrafish (Danio rerio), social isolation disrupts the expression of kiss1, kiss2, and their receptors (kiss1ra, kiss1rb).
Anastasiya P. Perova, Vladanka Goltz, Sarng S. Pyurveev, Alexey V. Lizunov, Edgar A. Sekste, Alexander M. Potapkin, Sergei O. Eresko, Alexander V. Lysakovsky, Marat I. Airapetov, Andrei А. Lebedev, Petr D. Shabanov   +10 more
doaj   +2 more sources

Genetic and epigenetic aspects of the and genes in pubertal development and central precocious puberty: A review [PDF]

Precision and Future Medicine, 2023
The onset of puberty is a pivotal developmental milestone, and the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone is a key factor in the initiation of puberty. Both kisspeptin and its receptor (KISS1) and KISS1 receptor (KISS1R)
Ahreum Kwon
doaj   +1 more source

The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease. [PDF]

PLoS One, 2016
Multiple myeloma is one of the most common hematological diseases and is characterized by an aberrant proliferation of plasma cells within the bone marrow. As a result of crosstalk between cancer cells and the bone microenvironment, bone homeostasis is disrupted leading to osteolytic lesions and poor prognosis. Current diagnostic strategies for myeloma
Dotterweich J, Tower RJ, Brandl A, Müller M, Hofbauer LC, Beilhack A, Ebert R, Glüer CC, Tiwari S, Schütze N, Jakob F.   +10 more
europepmc   +6 more sources

Inactivating KISS1 Mutation and Hypogonadotropic Hypogonadism [PDF]

, 2012
Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B stimulate GnRH release.
Ozbek, Mehmet N., Yuksel, Bilgin, Tello, Javier A., Gurbuz, Fatih, Yilmaz, M. Bertan, Temiz, Fatih, Erdogan, Seref, Kotan, L. Damla, Millar, Robert P., Topaloglu, A. Kemal   +9 more
core   +5 more sources

Kiss1 receptor knockout exacerbates airway hyperresponsiveness and remodeling in a mouse model of allergic asthma. [PDF]

Respir Res
In asthma, sex-steroids signaling is recognized as a critical regulator of disease pathophysiology. However, the paradoxical role of sex-steroids, especially estrogen, suggests that an upstream mechanism or even independent of estrogen plays an important role in regulating asthma pathophysiology.
Ambhore NS, Balraj P, Kumar A, Reza MI, Ramakrishnan YS, Tesch J, Lohana S, Sathish V.   +7 more
europepmc   +4 more sources

High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors

Endocrine-Related Cancer, 2007
Abstract KiSS1 is a putative metastasis suppressor gene in melanoma and breast cancer-encoding kisspeptins, which are also described as neuroendocrine regulators of the gonadotropic axis. Negative as well as positive regulation of KiSS1 gene expression by estradiol (E2) has been reported in the hypothalamus.
Marot, D., Bieche, I., Aumas, C., Esselin, S., Bouquet, C., Vacher, S., Lazennec, Gwendal, Perricaudet, M., Kuttenn, F., Lidereau, R., Roux N, De   +10 more
openaire   +5 more sources

KISS1R and ANKRD31 Cooperate to Enhance Leydig Cell Gene Expression via the Cytoskeletal-Nucleoskeletal Pathway

Frontiers in Cell and Developmental Biology, 2022
Kisspeptins are involved in the regulation of hypothalamic-pituitary-gonadal axis, Leydig cell functions, and testosterone secretion, acting as endogenous ligands of the KISS1 receptor.
Giulia Ricci, Florian Guillou, Angela Catizone, Vincenza Grazia Mele, Martina Moggio, Teresa Chioccarelli, Nadia Diano, Rosaria Meccariello, Riccardo Pierantoni, Silvia Fasano, Gilda Cobellis, Rosanna Chianese, Francesco Manfrevola   +12 more
doaj   +1 more source

Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice

Nature Communications, 2023
Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exerting a surge-
Jose M. Ramos-Pittol, Isabel Fernandes-Freitas, Alexandra Milona, Stephen M. Manchishi, Kara Rainbow, Brian Y. H. Lam, John A. Tadross, Anthony Beucher, William H. Colledge, Inês Cebola, Kevin G. Murphy, Irene Miguel-Aliaga, Giles S. H. Yeo, Waljit S. Dhillo, Bryn M. Owen   +14 more
doaj   +1 more source