Results 11 to 20 of about 1,110,898 (202)

Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in Prostate Cancer [PDF]

Anticancer Research, 2020
Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. In contrast to localized disease, metastatic PCa leads to increased mortality. Kisspeptin (KISS1) functions as a metastasis suppressor in various cancers. The aim of this study was to detect the expression of KISS1 and its receptor GPR54 (KISS1R) in prostate cancer.The ...
Xoxakos, I., Petraki, C., Msauel, P., Armakolas, A., Grigorakis, A., Stefanakis, S., Koutsilieris, M.   +6 more
openaire   +4 more sources

KISS1/KISS1R in Cancer: Friend or Foe?

Frontiers in Endocrinology, 2018
The KISS1 gene encodes KISS1, a protein that is rapidly processed in serum into smaller but biologically active peptides called kisspeptins (KPs). KISS1 and the KPs signal via the G-protein coupled receptor KISS1R.
Stephania Guzman, Stephania Guzman, Muriel Brackstone, Sally Radovick, Sally Radovick, Andy V. Babwah, Andy V. Babwah, Moshmi M. Bhattacharya, Moshmi M. Bhattacharya, Moshmi M. Bhattacharya   +9 more
doaj   +2 more sources

G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance. [PDF]

Sci Rep, 2017
AbstractTriple-negative breast cancer (TNBC) lacks the expression of estrogen receptor α, progesterone receptor and human epidermal growth factor receptor 2 (HER2). TNBC patients lack targeted therapies, as they fail to respond to endocrine and anti-HER2 therapy.
Blake A, Dragan M, Tirona RG, Hardy DB, Brackstone M, Tuck AB, Babwah AV, Bhattacharya M.   +7 more
europepmc   +6 more sources

Supplemental Material, supplemental_table_1_primer_sequences - Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells—Potential Pathogenesis of Polycystic Ovary Syndrome

, 2018
Supplemental Material, supplemental_table_1_primer_sequences for Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells—Potential Pathogenesis of Polycystic Ovary Syndrome by Kai-Lun Hu, Hongcui Zhao, Zheying Min, Yilei He, Tianjie Li, Xiumei Zhen, Yun Ren, Hsun-Ming Chang, Yang Yu, and Rong Li in Reproductive ...
Hu, Kai-Lun, Zhao, Hongcui, Min, Zheying, He, Yilei, Li, Tianjie, Zhen, Xiumei, Ren, Yun, Chang, Hsun-Ming, Yu, Yang, Li, Rong   +9 more
core   +4 more sources

Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats

The Journal of Reproduction and Development
Hypothalamic arcuate (ARC) kisspeptin neurons are considered the gonadotropin-releasing hormone pulse generator in rats. In virgin rats, the expression of the ARC kisspeptin gene (Kiss1) is repressed by proestrous levels of estradiol-17β (high E2) but ...
Marina TAKIZAWA, Sae MIYAZAKI, Hitomi TSUCHIDA, Mayuko NAGAE, Shunsuke SEKI, Masumi HIRABAYASHI, Fumitaka OSAKADA, Naoko INOUE, Hiroko TSUKAMURA, Yoshihisa UENOYAMA   +9 more
doaj   +2 more sources

Role of the kisspeptin/KISS1 receptor system in the testicular development of mice. [PDF]

J Chin Med Assoc, 2021
Background: Kisspeptin and its receptor KISS1R have been found to be essential regulators of reproductive function. Previous data have revealed the presence of Kiss1 and Kiss1r mRNAs in the hypothalamus and the testis of humans and rodents.
Chiang CM, Chiu HY, Jong DS, Wu LS, Lee YJ, Chiu CH.   +5 more
europepmc   +7 more sources

Evolutionary insights into the steroid sensitive kiss1 and kiss2 neurons in the vertebrate brain

Frontiers in Endocrinology, 2012
Kisspeptin was originally found as a peptide product of Kiss1gene and is now supposed to be an essential central regulator of reproduction in mammals. However, there is now a growing body of evidence to suggest that kiss2, the paralogous gene for kiss1 ...
Shinji eKanda, Yoshitaka eOka
doaj   +2 more sources

Evaluation of KISS1 Receptor Gene Expression in Egyptian Female Patients with Breast Cancer. [PDF]

Asian Pac J Cancer Prev, 2022
Breast cancer is the second most common cancer in the world. Many metastasis suppressor genes were identified, including the KISS1 gene which encodes for a 145 amino acid protein (kisspeptin-145), which undergoes proteolytic cleavage resulting in kisspeptin-14, -13 and -10. All of these proteins can activate KISS1 receptor (KISS1R).
Gomaa SH, Zaki MA, Sultan MH, Sultan MH, Dwedar FI, Elzain Zidan EH.   +5 more
europepmc   +3 more sources

Effect of social isolation and kisspeptin analogues (KS6 and KS10) on the expression of KISS1, KISS2, and their receptors in danio rerio

Research Results in Pharmacology
Introduction: The kisspeptin system regulates both reproductive and stress-related neuroendocrine functions. In zebrafish (Danio rerio), social isolation disrupts the expression of kiss1, kiss2, and their receptors (kiss1ra, kiss1rb).
Anastasiya P. Perova, Vladanka Goltz, Sarng S. Pyurveev, Alexey V. Lizunov, Edgar A. Sekste, Alexander M. Potapkin, Sergei O. Eresko, Alexander V. Lysakovsky, Marat I. Airapetov, Andrei А. Lebedev, Petr D. Shabanov   +10 more
doaj   +2 more sources

High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors

Endocrine-Related Cancer, 2007
Abstract KiSS1 is a putative metastasis suppressor gene in melanoma and breast cancer-encoding kisspeptins, which are also described as neuroendocrine regulators of the gonadotropic axis. Negative as well as positive regulation of KiSS1 gene expression by estradiol (E2) has been reported in the hypothalamus.
Marot, D., Bieche, I., Aumas, C., Esselin, S., Bouquet, C., Vacher, S., Lazennec, Gwendal, Perricaudet, M., Kuttenn, F., Lidereau, R., Roux N, De   +10 more
openaire   +5 more sources