Results 41 to 50 of about 2,756 (195)
Silent Mutation in KISS1 and KISS1R and Unexplained Infertility [PDF]
Avicenna Journal of Medical Biochemistry, 2015 Kisspeptin (KP) is a set of peptides coded by the KISS1 gene that is a metastasis suppressor gene located on chromosome 1q32. It plays an important role in regulation of hypothalamic-pituitary-gonadal axis (1). The association of KP with the disruption of hypothalamic-pituitarygonadal axis, can be exemplified by high concordance of the phenotypes ...
Rehman, Jamil, Fatima, Alam
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KISS1R polymorphism rs587777844 (Tyr313His) is linked to female infertility
British Journal of Biomedical Science, 2021 Infertility is a reproductive system disorder, defined as the failure to become pregnant after 12 months of regular, unprotected intercourse, or to produce a viable infant [1,2].
Z Siahpoosh +4 more
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Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
Scientific Reports, 2018 The roles of kisspeptin signaling outside the hypothalamus in the brain are unknown. We examined here the impact of Kiss1r-deletion on hippocampus-related behaviors of anxiety and spatial learning in adult male mice using two mouse models.
Sarah Delmas +3 more
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Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype [PDF]
, 2019 Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity ...
Tolson, Kristen P +4 more
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Kisspeptins inhibit human airway smooth muscle proliferation
JCI Insight, 2022 Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous role for estrogen in airway remodeling, making it unclear whether sex hormones are protective or ...
Niyati A. Borkar +5 more
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Endokrynologia Polska, 2021 INTRODUCTION: Pituitary neuroendocrine tumours (PitNETs), traditionally designated as pituitary adenomas, show elatively frequent invasive growth with exceptional metastatic potential, the causes of which are not entirely elucidated.
Milena Mihajlovic +13 more
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Biomedicines, 2021 Kisspeptins (Kp) are RF-amide neuropeptide regulators of the reproductive axis that also influence anxiety, locomotion, and metabolism. We aimed to investigate the effects of intracerebroventricular Kp-8 (an N-terminally truncated octapeptide) treatment ...
Katalin Eszter Ibos +6 more
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Frontiers in Endocrinology, 2023 IntroductionMale reproduction is under the control of the hypothalamus–pituitary–gonadal (HPG) axis. The endocannabinoid system (ECS) and the kisspeptin system (KS) are two major signaling systems in the central and peripheral control of reproduction ...
Marianna Marino +14 more
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Scientific Reports, 2023 We evaluated whether the administration of kisspeptin-10 (Kp10) is capable of restoring gonadal function in hypothyroid male rats. Hypothyroidism was induced with 6-propyl-2-thiouracil (PTU) for three months.
Luciano Cardoso Santos +14 more
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Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy [PDF]
GeroScience, 2023 Abstract The prevalence of chronic kidney disease (CKD) is increasing globally, especially in elderly patients. Uremic cardiomyopathy is a common cardiovascular complication of CKD, characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and fibrosis.
Hoa Dinh +30 more
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