Results 41 to 50 of about 2,946 (202)

Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats

Biomedicines, 2021
Kisspeptins (Kp) are RF-amide neuropeptide regulators of the reproductive axis that also influence anxiety, locomotion, and metabolism. We aimed to investigate the effects of intracerebroventricular Kp-8 (an N-terminally truncated octapeptide) treatment ...
Katalin Eszter Ibos, Éva Bodnár, Zsolt Bagosi, Zsolt Bozsó, Gábor Tóth, Gyula Szabó, Krisztina Csabafi   +6 more
doaj   +1 more source

KISSPEPTIN INDUCES MESENCHYMAL TRANSITION (MES) VIA PROTEOMIC REGULATION OF MES-TRANSCRIPTION FACTORS AND CYTOSKELETAL REMODELLING PROTEINS FOR THE PROMOTION OF CELL INVASION IN KISS1R-EXPRESSING GLIOBLASTOMA CELLS [PDF]

, 2023
Glioblastoma (GBM) is the deadliest brain tumour. Epithelial-Mesenchymal-like transition (MES) is a crucial mechanism that influences GBM motility, conferring GBM its highly infiltrative nature.
Min Yee Chow, Syafiq Asnawi Zainal Abidin, Muhamad Noor Alfarizal Kamarudin, Jeyanthy Eswaran, Eswaran, Jeyanthy, Rakesh Naidu, Naidu, Rakesh; id_orcid, Zainal Abidin, Syafiq Asnawi; id_orcid, Chow, Min Yee; id_orcid, Kamarudin, Muhamad Noor Alfarizal; id_orcid   +9 more
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The interplay between kisspeptin and endocannabinoid systems modulates male hypothalamic and gonadic control of reproduction in vivo

Frontiers in Endocrinology, 2023
IntroductionMale reproduction is under the control of the hypothalamus–pituitary–gonadal (HPG) axis. The endocannabinoid system (ECS) and the kisspeptin system (KS) are two major signaling systems in the central and peripheral control of reproduction ...
Marianna Marino, Raffaella D’Auria, Elena Mele, Grazia Maria Giovanna Pastorino, Grazia Maria Giovanna Pastorino, Paola Di Pietro, Stefania D’Angelo, Natalia Della Rocca, Francesca Felicia Operto, Carmine Vecchione, Silvia Fasano, Riccardo Pierantoni, Andrea Viggiano, Rosaria Meccariello, Antonietta Santoro   +14 more
doaj   +1 more source

Kisspeptin treatment reverses high prolactin levels and improves gonadal function in hypothyroid male rats

Scientific Reports, 2023
We evaluated whether the administration of kisspeptin-10 (Kp10) is capable of restoring gonadal function in hypothyroid male rats. Hypothyroidism was induced with 6-propyl-2-thiouracil (PTU) for three months.
Luciano Cardoso Santos, Jeane Martinha dos Anjos Cordeiro, Larissa da Silva Santana, Erikles Macêdo Barbosa, Bianca Reis Santos, Letícia Dias Mendonça, Maria Clara da Silva Galrão Cunha, William Morais Machado, Larissa Rodrigues Santana, Maíra Guimarães Kersul, Patrícia Costa Henriques, Roberta Araújo Lopes, Paola Pereira das Neves Snoeck, Raphael Escorsim Szawka, Juneo Freitas Silva   +14 more
doaj   +1 more source

An Isolated Hypogonadotropic Hypogonadism due to a L102P Inactivating Mutation of KISS1R/GPR54 in a Large Family

Case Reports in Pediatrics, 2019
KISS1R (GPR54) mutations have been reported in several patients with congenital normosmic idiopathic hypogonadotropic hypogonadism (nIHH). We aim to describe in detail nIHH patients with KISS1R (GPR54) mutations belonging to one related extended family ...
Ahmad J. Alzahrani, Azzam Ahmad, Tariq Alhazmi, Lujin Ahmad   +3 more
doaj   +1 more source

Kiss1 Inhibits the Proliferation of Nasopharyngeal Carcinoma Cells Via Activation of the LKB1/AMPK Pathway

Frontiers in Oncology, 2022
Nasopharyngeal carcinoma (NPC) is a cancer that occurs in the nasopharynx. Infinite proliferation and distant metastasis are the main characteristics of NPC cells, and the main reason for the current failure of malignant tumor treatment.
Tingting Li, Yong Tian, Yixuan Wang, Zhen Cui, Zelai He, Xiao Wu, Yajun Zhang, Hao Jiang   +7 more
doaj   +1 more source

The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease. [PDF]

PLoS ONE, 2016
Multiple myeloma is one of the most common hematological diseases and is characterized by an aberrant proliferation of plasma cells within the bone marrow.
Julia Dotterweich, Robert J Tower, Andreas Brandl, Marc Müller, Lorenz C Hofbauer, Andreas Beilhack, Regina Ebert, Claus C Glüer, Sanjay Tiwari, Norbert Schütze, Franz Jakob   +10 more
doaj   +1 more source

Kisspeptin/Kisspeptin Receptor System in the Ovary

Frontiers in Endocrinology, 2018
Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic–pituitary–gonadal axis.
Kai-Lun Hu, Hongcui Zhao, Hsun-Ming Chang, Yang Yu, Jie Qiao   +4 more
doaj   +1 more source

Sexually dimorphic pubertal development and adipose tissue kisspeptin dysregulation in the obese and preeclamptic-like BPH/5 mouse model offspring

Frontiers in Physiology, 2023
Preeclampsia (PE) is a devastating hypertensive disorder of pregnancy closely linked to obesity. Long-term adverse outcomes may occur in offspring from preeclamptic pregnancies.
Viviane C. L. Gomes, Kalie F. Beckers, Kassandra R. Crissman, Camille A. Landry, Juliet P. Flanagan, Reham M. Awad, Fabio Del Piero, Chin-Chi Liu, Jenny L. Sones   +8 more
doaj   +1 more source

Induction of KISS1R expression by CRISPR activation in human embryonic stem cells

, 2022
Puberty initiation is a crucial physiological process in human development. A group of hypothalamic neurons secreting the gonadotropin-releasing hormone (GnRH) and expressing the kisspeptin receptor (KISS1R) plays a key role in launching puberty ...
Müller, Linda Helena
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