Results 51 to 60 of about 2,946 (202)

Genetic landscape of a neonatal hypogonadotropic hypogonadism series: Novel variants and phenotypic spectrum

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract To describe clinical presentation and genetic findings in a cohort of infants with congenital hypogonadotropic hypogonadism (CHH) diagnosed before 2 years of age. From a large cohort of patients who underwent next‐generation sequencing (NGS) for CHH between 2019 and 2025, we identified all patients tested at ≤2 years of age.
Karine Aouchiche, Laure Van Wormhoudt, Kevin Perge, Joanne Dornberger, Cindy Colson, Marine Delagrange, Clara Leroy, Jennifer Ledmazel, Vanessa Menut, Jessica Benarrous Jaillet, Djamel Bendifallah, Mohamad Hage Chehade, Christelle Dib, Anne Barlier, Thierry Brue, Rachel Reynaud, Alexandru Saveanu   +16 more
wiley   +1 more source

Kiss1 receptor knockout exacerbates airway hyperresponsiveness and remodeling in a mouse model of allergic asthma

Respiratory Research
Background In asthma, sex-steroids signaling is recognized as a critical regulator of disease pathophysiology. However, the paradoxical role of sex-steroids, especially estrogen, suggests that an upstream mechanism or even independent of estrogen plays ...
Nilesh Sudhakar Ambhore, Premanand Balraj, Ashish Kumar, Mohammad Irshad Reza, Yogaraj S. Ramakrishnan, Jacob Tesch, Sahil Lohana, Venkatachalem Sathish   +7 more
doaj   +1 more source

Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor

Cell Reports
Summary: Kisspeptin signaling through its G protein-coupled receptor, KISS1R, plays an indispensable role in regulating reproduction via the hypothalamic-pituitary-gonadal axis.
Shiyi Shen, Dongxue Wang, Heng Liu, Xinheng He, Yinglong Cao, Juanhua Chen, Shujie Li, Xi Cheng, H. Eric Xu, Jia Duan   +9 more
doaj   +1 more source

Three Siblings with Idiopathic Hypogonadotropic Hypogonadism in a Nonconsanguineous Family: A Novel KISS1R/GPR54 Loss-of-Function Mutation

JCRPE, 2019
Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disease caused by defects in the secretion of gonadotropin releasing hormone (GnRH) or the action of GnRH on the pituitary gonadotrophes.
Özlem Nalbantoğlu, Gülçin Arslan, Özge Köprülü, Filiz Hazan, Semra Gürsoy, Behzat Özkan   +5 more
doaj   +1 more source

Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Stress impairs reproduction, at least in part, by inhibition of Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells and suppression of gonadotropin secretion. However, the mechanism for this inhibition is not clear. Neuropeptide Y (NPY) is a pleiotropic molecule that is produced in neurons throughout the brain and mediates several physiological ...
Lauren A. Young, Evan R. Hurtado, Kyla D. Jacobs, Zhi Mei Maria Lee, Casey C Nestor, Richard B. McCosh   +5 more
wiley   +1 more source

Repression of kiss1r-2 by miR-24 in RTS34st cell line.

, 2013
The cells were transiently transfected with pmirGLO-kiss1r-2 vector construct or pmirGLO-kiss1r-2 vector construct together with miR-24 mimic or pmirGLO-scramble together with miR-24 mimic for 48 h followed by dual-luciferase reporter assay.
Teshome Tilahun Bizuayehu (405465), Steinar D. Johansen (8256), Igor Babiak (405466), Jorge M. O. Fernandes (166243)   +3 more
core   +1 more source

Expression of functional KISS1 and KISS1R system is altered in human pituitary adenomas: evidence for apoptotic action of kisspeptin-10

, 2011
CONTEXT: KISS1 was originally identified as a metastasis-suppressor gene able to inhibit tumor progression. KISS1 gene products, the kisspeptins, bind to a G-protein-coupled receptor (KISS1R, formerly GPR54), which is highly expressed in placenta ...
Luque R. M., ZATELLI, Maria Chiara, Moreno Fernández J., Jiménez Reina L., Resmini E., DEGLI UBERTI, Ettore, Benito López P., Malagón M. M., Castaño J. P., Molina M., Leal Cerro A., Diéguez C., Soto A., Quintero A., Martínez Fuentes A. J., Webb S. M., Vázquez Martínez R., Gahete M. D., de la Riva A., Susan M Webb, Raul M Luque, Marcelo Molina, Ettore C degli Uberti, Antonio J Martínez-Fuentes, Manuel D Gahete, Jesús Moreno-Fernández, Rafael Vázquez-Martínez, María M Malagón, Pedro Benito-López, Carlos Diéguez, Maria C Zatelli, Justo P Castaño, Alfonso Soto, Ana Quintero, Eugenia Resmini, Alfonso Leal-Cerro, Luis Jiménez-Reina, Andrés de la Riva   +37 more
core   +2 more sources

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, Volume 18, Issue 7, Page 862-876, July 2026.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Evaluación de los receptores Kiss1r en el útero de ratas Wistar puberales [PDF]

, 2022
"La maduración del útero en los mamíferos se da en el periodo posnatal en donde se establece el crecimiento y la morfogénesis propia del órgano. En el desarrollo uterino posnatal ocurre la organización y estratificación del estroma endometrial, la ...
De la Rosa Priego, Joaquina
core  

Comprehensive RNA-seq reveals molecular changes in kidney malignancy among people living with HIV

Molecular Therapy: Nucleic Acids, 2022
To heighten the awareness of kidney malignancy in patients with HIV infection to facilitate the early diagnosis of kidney cancer, the differentially expressed mRNAs were analyzed in this malignant tumor using RNA sequencing.
Juan Bao, Jianqing Ye, Jingjing Xu, Shanshan Liu, Lin Wang, Zehuan Li, Qiuyue Li, Feng Liu, Xiaomeng He, Heng Zou, Yanling Feng, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu, Tongyu Zhu, Jin Wang   +15 more
doaj   +1 more source