Results 51 to 60 of about 2,756 (195)

Kiss1 Inhibits the Proliferation of Nasopharyngeal Carcinoma Cells Via Activation of the LKB1/AMPK Pathway

Frontiers in Oncology, 2022
Nasopharyngeal carcinoma (NPC) is a cancer that occurs in the nasopharynx. Infinite proliferation and distant metastasis are the main characteristics of NPC cells, and the main reason for the current failure of malignant tumor treatment.
Tingting Li, Yong Tian, Yixuan Wang, Zhen Cui, Zelai He, Xiao Wu, Yajun Zhang, Hao Jiang   +7 more
doaj   +1 more source

The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease. [PDF]

PLoS ONE, 2016
Multiple myeloma is one of the most common hematological diseases and is characterized by an aberrant proliferation of plasma cells within the bone marrow.
Julia Dotterweich, Robert J Tower, Andreas Brandl, Marc Müller, Lorenz C Hofbauer, Andreas Beilhack, Regina Ebert, Claus C Glüer, Sanjay Tiwari, Norbert Schütze, Franz Jakob   +10 more
doaj   +1 more source

Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure [PDF]

, 2016
Kisspeptin controls reproduction by stimulating gonadotrophin-releasing hormone neurones via its receptor Kiss1r. Kiss1r is also expressed other brain areas and in peripheral tissues, suggesting additional nonreproductive roles.
Nasamran, Chanond, Tolson, Kristen P, Smith, Jeremy T, Kauffman, Alexander S, De Bond, Julie‐Ann P   +4 more
core   +1 more source

Kisspeptin/Kisspeptin Receptor System in the Ovary

Frontiers in Endocrinology, 2018
Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic–pituitary–gonadal axis.
Kai-Lun Hu, Hongcui Zhao, Hsun-Ming Chang, Yang Yu, Jie Qiao   +4 more
doaj   +1 more source

The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration. [PDF]

, 2021
Dissertation (MSc)--University of Pretoria, 2021.Kisspeptin receptor, also known as KISS1R, is the endogenous receptor for the ligand peptide, kisspeptin. It is a G-protein coupled receptor that couples through the Gαq/11 pathway.

core  

Sexually dimorphic pubertal development and adipose tissue kisspeptin dysregulation in the obese and preeclamptic-like BPH/5 mouse model offspring

Frontiers in Physiology, 2023
Preeclampsia (PE) is a devastating hypertensive disorder of pregnancy closely linked to obesity. Long-term adverse outcomes may occur in offspring from preeclamptic pregnancies.
Viviane C. L. Gomes, Kalie F. Beckers, Kassandra R. Crissman, Camille A. Landry, Juliet P. Flanagan, Reham M. Awad, Fabio Del Piero, Chin-Chi Liu, Jenny L. Sones   +8 more
doaj   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, Volume 18, Issue 7, Page 862-876, July 2026.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor

Cell Reports
Summary: Kisspeptin signaling through its G protein-coupled receptor, KISS1R, plays an indispensable role in regulating reproduction via the hypothalamic-pituitary-gonadal axis.
Shiyi Shen, Dongxue Wang, Heng Liu, Xinheng He, Yinglong Cao, Juanhua Chen, Shujie Li, Xi Cheng, H. Eric Xu, Jia Duan   +9 more
doaj   +1 more source

Three Siblings with Idiopathic Hypogonadotropic Hypogonadism in a Nonconsanguineous Family: A Novel KISS1R/GPR54 Loss-of-Function Mutation

JCRPE, 2019
Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disease caused by defects in the secretion of gonadotropin releasing hormone (GnRH) or the action of GnRH on the pituitary gonadotrophes.
Özlem Nalbantoğlu, Gülçin Arslan, Özge Köprülü, Filiz Hazan, Semra Gürsoy, Behzat Özkan   +5 more
doaj   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source