Results 71 to 80 of about 2,756 (195)

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

Repression of kiss1r-2 by miR-24 in RTS34st cell line.

, 2013
The cells were transiently transfected with pmirGLO-kiss1r-2 vector construct or pmirGLO-kiss1r-2 vector construct together with miR-24 mimic or pmirGLO-scramble together with miR-24 mimic for 48 h followed by dual-luciferase reporter assay.
Teshome Tilahun Bizuayehu (405465), Steinar D. Johansen (8256), Igor Babiak (405466), Jorge M. O. Fernandes (166243)   +3 more
core   +1 more source

Determination of KISS1, KISS1R and Kisspeptin in Fat Tissue of Normal Weight and Obese Humans and Correlations between Serum Kisspeptin and Leptin

Siriraj Medical Journal, 2017
Kisspeptin, a neuropeptide mainly expressed in the hypothalamus, has a major role in reproductive regulation. Previous studies showed that Kiss1 mRNA expression is also found in adipose tissue in rats.
Chantacha Sitticharoon, Vipada Boonpuan, Chalermchai Mitrpant, Malika Churintaraphan   +3 more
doaj  

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Modeling and functional consequences of the p.Tyr313His KISS1R mutation. Panel A.

, 2013
Evolutionary conservation of Tyr313. Tyr313 is totally conserved among KISS1R homologs. Hs: Homo sapiens; Nl: Nomascus leucogenys; Cf: Canis familiaris; Bt: Bos taurus; Mm: Mus musculus; Rn: Rattus norvegicus; Sh: Sarcophilus harrisii; Oa ...
Ronan Roussel (101806), Bruno Francou (101791), Marc Lombès (39125), Jérôme Fagart (101795), Jacques Young (101833), Jérôme Bouligand (101786), Frédéric Brioude (101781), Say Viengchareun (39121), Sylvie Brailly-Tabard (101823), Laurent Combettes (101816), Anne Guiochon-Mantel (101841)   +10 more
core   +1 more source

Expression of kisspeptin/kiss1r system in developing hypothalamus of female rat and the possible effects on reproduction development and maintenance [PDF]

, 2016
BackgroundThe kisspeptin/kiss1r system, expressed in the hypothalamic arcuate nucleus, has been proclaimed as one of the most powerful factors of the reproduction axis, according to recent researches in the reproductive field.
Luo, Qian-Qian, Hou, Yun, Zhang, Hong-Qin, Yin, Na   +3 more
core   +1 more source

KISSPEPTIN INDUCES MESENCHYMAL TRANSITION (MES) VIA PROTEOMIC REGULATION OF MES-TRANSCRIPTION FACTORS AND CYTOSKELETAL REMODELLING PROTEINS FOR THE PROMOTION OF CELL INVASION IN KISS1R-EXPRESSING GLIOBLASTOMA CELLS [PDF]

, 2023
Glioblastoma (GBM) is the deadliest brain tumour. Epithelial-Mesenchymal-like transition (MES) is a crucial mechanism that influences GBM motility, conferring GBM its highly infiltrative nature.
Min Yee Chow, Syafiq Asnawi Zainal Abidin, Muhamad Noor Alfarizal Kamarudin, Zainal Abidin, Syafiq Asnawi, Jeyanthy Eswaran, Eswaran, Jeyanthy, Rakesh Naidu, Naidu, Rakesh, Chow, Min Yee, Kamarudin, Muhamad Noor Alfarizal   +9 more
core   +1 more source

Role of Kisspeptin-GPR54 system in regulation of reproductive functions in human and other mammals

Pakistan Journal of Pharmaceutical Sciences, 2021
Kisspeptin is a 54- amino acid peptide that acts as a ligand of a receptor called GPR54 which is basically a transmembrane receptor that spins seven times across the cell membrane and coupled with G-protein.
Ikram Ilahi, Taqweem Ul Haq
doaj   +1 more source

Identification and Functional Characterization of a Novel SEMA3A Exon Deletion Variant in Kallmann Syndrome

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
The study identified a novel SEMA3A exons 6–9 deletion variant in Kallmann syndrome that impairs GnRH neuronal migration and alters cell migration, gonad development, and synaptic pathways. The study expands mutation spectrum and offers mechanistic insights for clinical diagnosis of Kallmann syndrome.
Shaolian Zang, Shasha Zhou, Qingxu Liu, Xiaoqin Yin, Pin Li   +4 more
wiley   +1 more source

Developmental Profile and Sexually Dimorphic Expression of Kiss1 and Kiss1r in the Fetal Mouse Brain [PDF]

Frontiers in Endocrinology, 2013
The hypothalamic-pituitary-gonadal axis (HPG) is a complex neuroendocrine circuit involving multiple levels of regulation. Kisspeptin neurons play essential roles in controlling the HPG axis from the perspectives of puberty onset, oscillations of gonadotropin releasing hormone (GnRH) neuron activity, and the pre-ovulatory LH surge.
Knoll, John Gabriel, Clay, Colin M., Bouma, Gerrit J., Henion, Timothy R., Schwarting, Gerald A., Millar, Robert P., Tobet, Stuart A.   +6 more
openaire   +5 more sources