Results 61 to 70 of about 2,946 (202)
Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar +7 more
wiley +1 more source
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 4, Page 933-946, April 2026.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Sexual Dimorphism in Kisspeptin and Kiss1R in the Ventrolateral Periaqueductal Gray [PDF]
, 2021 Chronic pain manifests as a debilitating pathological state that affects up to 10% of the global population. Previous investigations revealed a disproportionate distribution of pain experience between sexes with females reporting a higher prevalence of ...
Hernandez, Jacqueline
core
The Role of SNPs in the Pathogenesis of Idiopathic Central Precocious Puberty in Girls
Children, 2023 The initiation of puberty is a crucial timepoint of development, with its disruptions being associated with multiple physical and psychological complications.
Konstantina Toutoudaki +5 more
doaj +1 more source
Acta Physiologica, Volume 242, Issue 4, April 2026.ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos +9 more
wiley +1 more source
Siriraj Medical Journal, 2017 Kisspeptin, a neuropeptide mainly expressed in the hypothalamus, has a major role in reproductive regulation. Previous studies showed that Kiss1 mRNA expression is also found in adipose tissue in rats.
Chantacha Sitticharoon +3 more
doaj
Recapitulating thyroid cancer histotypes through engineering embryonic stem cells
Nature Communications, 2023 Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. Here, the authors show the ability of human embryonic stem cells (hESCs) to recapitulate the different TC histotypes upon specific genomic alterations delivered by CRISPR-Cas9 and ...
Veronica Veschi +26 more
doaj +1 more source
Role of Kisspeptin-GPR54 system in regulation of reproductive functions in human and other mammals
Pakistan Journal of Pharmaceutical Sciences, 2021 Kisspeptin is a 54- amino acid peptide that acts as a ligand of a receptor called GPR54 which is basically a transmembrane receptor that spins seven times across the cell membrane and coupled with G-protein.
Ikram Ilahi, Taqweem Ul Haq
doaj +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source