Results 61 to 70 of about 2,756 (195)
Normosmic idiopathic hypogonadotrophic hypogonadism due to a rare KISS1R gene mutation [PDF]
Endocrinology, Diabetes & Metabolism Case Reports, 2018 Summary Hypogonadotrophic hypogonadism is due to impaired or reduced gonadotrophin secretion from the pituitary gland. In the absence of any anatomical or functional lesions of the pituitary or hypothalamic gland, the hypogonadotrophic hypogonadism is referred to as idiopathic hypogonadotrophic hypogonadism (IHH). We present a case of
Chelaghma, N +6 more
openaire +3 more sources
Family pedigrees and corresponding KISS1R mutations.
, 2013 Panel A. Pedigree of the family with homozygous KISS1R c.937T>C mutation. The proband, subject II-8 (arrow), and his two affected sisters, subjects II-1 and II-3, were homozygous for the c.937T>C mutation.
Ronan Roussel (101806) +10 more
core +1 more source
Comprehensive RNA-seq reveals molecular changes in kidney malignancy among people living with HIV
Molecular Therapy: Nucleic Acids, 2022 To heighten the awareness of kidney malignancy in patients with HIV infection to facilitate the early diagnosis of kidney cancer, the differentially expressed mRNAs were analyzed in this malignant tumor using RNA sequencing.
Juan Bao +15 more
doaj +1 more source
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
Recapitulating thyroid cancer histotypes through engineering embryonic stem cells
Nature Communications, 2023 Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. Here, the authors show the ability of human embryonic stem cells (hESCs) to recapitulate the different TC histotypes upon specific genomic alterations delivered by CRISPR-Cas9 and ...
Veronica Veschi +26 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 4, Page 933-946, April 2026.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Induction of KISS1R expression by CRISPR activation in human embryonic stem cells
, 2022 Puberty initiation is a crucial physiological process in human development. A group of hypothalamic neurons secreting the gonadotropin-releasing hormone (GnRH) and expressing the kisspeptin receptor (KISS1R) plays a key role in launching puberty ...
Müller, Linda Helena
core
Acta Physiologica, Volume 242, Issue 4, April 2026.ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos +9 more
wiley +1 more source
PRR repeats in the intracellular domain of KISS1R are important for its export to cell membrane.: PRR repeats in intracellular domain of KISSIR [PDF]
, 2013 The National Institute of Health and Medical Research (INSERM, France) The Ministry of Research (France) The University Paris Diderot, Sorbonne Paris Cite (France) The National Institute of Blood Transfusion (INTS, France) The Laboratories of Excellence,
de Brevern, Alexandre +6 more
core +1 more source
The Role of SNPs in the Pathogenesis of Idiopathic Central Precocious Puberty in Girls
Children, 2023 The initiation of puberty is a crucial timepoint of development, with its disruptions being associated with multiple physical and psychological complications.
Konstantina Toutoudaki +5 more
doaj +1 more source