Results 91 to 100 of about 2,946 (202)

Reduced voluntary wheel running behaviour in Kiss1r knockout mice

Physiology & Behavior
Kisspeptin and its receptor, Kiss1r, are novel players in the central balance of energy intake and expenditure. Recent evidence also indicates that kisspeptin signalling is important in thermoregulation and generation of the circadian rhythm. We used global Kiss1r knockout mice (Kiss1r KO), which are hypogonadal and develop obesity, to determine the ...
Raj Patel, Aaron Gomes, Shane K Maloney, Jeremy T Smith   +3 more
openaire   +2 more sources

Spatial Transcriptomics Shows a Distinctive Tumour Microenvironment in the Invasive Versus Premalignant Portion of Early Cutaneous Squamous Cell Carcinoma

Experimental Dermatology, Volume 34, Issue 6, June 2025.
In this study, we compared gene expression patterns between the premalignant actinic keratosis (AK) and invasive cutaneous squamous cell carcinoma (SCC) portions within early‐stage cutaneous SCC tissue samples. We identified 29, 14, and 15 differentially expressed genes (DEGs) between the invasive SCC and premalignant AK portions in tumor cells, immune
Jeong‐An Gim, Chungyeul Kim, Hyun Jyung Oh, Ko Eun Kim, Jiehyun Jeon, Aeree Kim, Yoo Sang Baek   +6 more
wiley   +1 more source

The Mutual Modulation of Endocannabinoid and Kisspeptin Systems in Rat Testis

Endocrines
Background: The endocannabinoid system (ECS) and the Kisspeptin system (KS) play crucial roles in the central and peripheral regulation of male reproduction. The KS comprises Kisspeptins, the cleavage product of the Kiss1 protein, and its receptor Kiss1R;
Elena Mele, Mario Ruggiero, Filomena Mazzeo, Andrea Viggiano, Rosaria Meccariello   +4 more
doaj   +1 more source

KISS1 and KISS1R expression in gastric cancer.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2019
Kisspeptins, which are derived from the gene KISS1, supress tumor progression. We intended to investigate the production of KISS1 and its receptor (KISSR) in gastric cancer.The expression of KISS1 and KISS1R in both normal and cancer tissue was examined with immunohistochemistry in tissue specimens of 40 cases of gastric adenocarcinoma.KISS1 expression
Ioannis D, Kostakis, George, Agrogiannis, Aristeidis G, Vaiopoulos, Eleni, Mylona, Efstratios, Patsouris, Gregory, Kouraklis, Michael, Koutsilieris   +6 more
openaire   +1 more source

Kisspeptin Alleviates Human Hepatic Fibrogenesis by Inhibiting TGFβ Signaling in Hepatic Stellate Cells

Cells
The peptide hormone kisspeptin attenuates liver steatosis, metabolic dysfunction-associated steatohepatitis (MASH), and fibrosis in mouse models by signaling via the kisspeptin 1 receptor (KISS1R).
Kavita Prasad, Dipankar Bhattacharya, Shams Gamal Eldin Shams, Kimberly Izarraras, Tia Hart, Brent Mayfield, Maryjka B. Blaszczyk, Zhongren Zhou, Utpal B. Pajvani, Scott L. Friedman, Moshmi Bhattacharya   +10 more
doaj   +1 more source

Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1/KISS1R signaling

, 2015
Renal cell carcinoma (RCC) is a common urological cancer worldwide and is known to have a high risk of metastasis, which is considered responsible for more than 90% of cancer associated deaths. Honokiol is a small-molecule biphenol isolated from Magnolia
Castillo, Victor, Cheng, Shujie, Eliaz, Isaac, Sliva, Daniel   +3 more
core   +1 more source

Immunohistochemical study of KiSS1 and KiSS1R expression in human primary breast cancer: Association with breast cancer receptor status, proliferation markers and clinicopathological features [PDF]

, 2015
Recent studies have raised doubts about the protective role of KiSS1/KiSS1R in breast malignancy progression. However, the role of the KiSS1/KiSS1R system in primary breast cancer remains largely unknown.
Milewski, Robert, Kozlowski, Leszek, Koda, Mariusz, Wolczynsk, Slawomir, Jarzabek, Katarzyna   +4 more
core   +1 more source

Estudio in silico de sapogeninas esteroidales del efecto modulador de la activación de KISS1R [PDF]

, 2023
“El gen KiSS1, las KPs y el receptor KISS1R regulan el desarrollo y la progresión de varios tipos de cáncer. Existe un papel dual de la kisspeptina, por una parte actúan como supresores de la tumorigénesis y la metástasis en muchos tipos de cáncer, pero ...
Vicente Morales, Ángel de Jesús
core  

Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure [PDF]

, 2016
Kisspeptin controls reproduction by stimulating gonadotrophin-releasing hormone neurones via its receptor Kiss1r. Kiss1r is also expressed other brain areas and in peripheral tissues, suggesting additional nonreproductive roles.
Nasamran, Chanond, Tolson, Kristen P, Smith, Jeremy T, Kauffman, Alexander S, De Bond, Julie‐Ann P   +4 more
core   +1 more source

Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome.

, 2018
PURPOSE: The neurokinin B (NKB)/NK3 receptor (NK3R) and kisspeptin (KISS1)/kisspeptin receptor (KISS1R), two systems essential for reproduction, are present in human granulosa cells (GCs) of healthy women and contribute to the control of fertility, at ...
Tena-Sempere, Manuel, Candenas, Luz, Pinto, Francisco M, Prados, Nicolas, Blasco, Victor, Fernandez-Atucha, Ainhoa, Fernandez-Sanchez, Manuel   +6 more
core   +1 more source