Results 91 to 100 of about 2,756 (195)

Direct co-culturing with INA-6 cells significantly upregulates KISS1R expression in MSCs and OPCs.

, 2016
KISS1R expression analyses of MSCs and OPCs after direct co-culturing with the MM cell line INA-6 (A). Both MSCs and OPCs express significantly higher KISS1R levels (relative to EEF1A1 controls) in response to direct contact with MM cells (n = 5) (B). Up-
Lorenz C. Hofbauer (759669), Sanjay Tiwari (1669654), Norbert Schütze (306441), Franz Jakob (133384), Claus C. Glüer (347285), Robert J. Tower (2736013), Andreas Brandl (668766), Marc Müller (2736016), Regina Ebert (133381), Andreas Beilhack (63291), Julia Dotterweich (2736019)   +10 more
core   +1 more source

Neuroendocrine mechanisms responsible for elevated gonadotrophin‐releasing hormone and luteinising hormone pulses in polycystic ovary syndrome

Journal of Neuroendocrinology, Volume 37, Issue 8, August 2025.
Abstract Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in premenopausal individuals with ovaries worldwide. Despite the diagnostic features of anovulation, ovarian cysts, and hyperandrogenemia, which indicate that ovary dysfunction is the cause of the syndrome, changes in central neuroendocrine circuits are a ...
Aleisha M. Moore
wiley   +1 more source

Spatial Transcriptomics Shows a Distinctive Tumour Microenvironment in the Invasive Versus Premalignant Portion of Early Cutaneous Squamous Cell Carcinoma

Experimental Dermatology, Volume 34, Issue 6, June 2025.
In this study, we compared gene expression patterns between the premalignant actinic keratosis (AK) and invasive cutaneous squamous cell carcinoma (SCC) portions within early‐stage cutaneous SCC tissue samples. We identified 29, 14, and 15 differentially expressed genes (DEGs) between the invasive SCC and premalignant AK portions in tumor cells, immune
Jeong‐An Gim, Chungyeul Kim, Hyun Jyung Oh, Ko Eun Kim, Jiehyun Jeon, Aeree Kim, Yoo Sang Baek   +6 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Investigational Nonapeptide KISS1R Agonists with Testosterone-Suppressive Activity

, 2016
Metastin/kisspeptin is a 54 amino acid peptide ligand of the KISS1R receptor and is a critical regulator of GnRH secretion. The N-terminally truncated peptide, metastin(45–54), possesses a 10-fold higher receptor-binding affinity than full-length ...
Masaharu Nakayama (285382), Naoki Nishizawa (1773700), Kimiko Nishibori (1773715), Hirokazu Matsumoto (1884082), Yoshihiro Ishibashi (1884085), Tetsuya Ohtaki (1773685), Chieko Kitada (1773679), Hisanori Matsui (1773688), Taiji Asami (1773697), Shin-ichi Matsumoto (1773706), Naoki Tarui (1773682), Masashi Yamaguchi (276947), Yasuko Horikoshi (1884088)   +12 more
core   +1 more source

Evaluación de los receptores Kiss1r en el útero de ratas Wistar puberales [PDF]

, 2022
"La maduración del útero en los mamíferos se da en el periodo posnatal en donde se establece el crecimiento y la morfogénesis propia del órgano. En el desarrollo uterino posnatal ocurre la organización y estratificación del estroma endometrial, la ...
De la Rosa Priego, Joaquina
core  

The Expression of Kisspeptins and Matrix Metalloproteinases in Extragenital Endometriosis

Biomedicines
Endometriosis is characterized by a condition where endometrial tissue grows outside the uterine cavity. The mechanisms of endometrium growth during endometriosis might be similar to the development of a tumor.
Tatiana Kleimenova, Victoria Polyakova, Natalia Linkova, Anna Drobintseva, Dmitriy Medvedev, Alexander Krasichkov   +5 more
doaj   +1 more source

Comprehensive chemoanatomical mapping, and the gonadal regulation, of seven kisspeptin neuronal populations in the mouse brain

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract Kisspeptinergic signaling is well‐established as crucial for the regulation of reproduction, but its potential broader role in brain function is less understood. This study investigates the distribution and chemotyping of kisspeptin‐expressing neurons within the mouse brain.
Vito S. Hernández, Mario A. Zetter, Oscar R. Hernández‐Pérez, Rafael Hernández‐González, Ignacio Camacho‐Arroyo, Robert P. Millar, Lee E. Eiden, Limei Zhang   +7 more
wiley   +1 more source

Kisspeptin Alleviates Human Hepatic Fibrogenesis by Inhibiting TGFβ Signaling in Hepatic Stellate Cells

Cells
The peptide hormone kisspeptin attenuates liver steatosis, metabolic dysfunction-associated steatohepatitis (MASH), and fibrosis in mouse models by signaling via the kisspeptin 1 receptor (KISS1R).
Kavita Prasad, Dipankar Bhattacharya, Shams Gamal Eldin Shams, Kimberly Izarraras, Tia Hart, Brent Mayfield, Maryjka B. Blaszczyk, Zhongren Zhou, Utpal B. Pajvani, Scott L. Friedman, Moshmi Bhattacharya   +10 more
doaj   +1 more source

KISS1 and KISS1R expression in gastric cancer.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2019
Kisspeptins, which are derived from the gene KISS1, supress tumor progression. We intended to investigate the production of KISS1 and its receptor (KISSR) in gastric cancer.The expression of KISS1 and KISS1R in both normal and cancer tissue was examined with immunohistochemistry in tissue specimens of 40 cases of gastric adenocarcinoma.KISS1 expression
Ioannis D, Kostakis, George, Agrogiannis, Aristeidis G, Vaiopoulos, Eleni, Mylona, Efstratios, Patsouris, Gregory, Kouraklis, Michael, Koutsilieris   +6 more
openaire   +1 more source

Investigation of KISS1/KISS1R gene expression and KISS1 rs5780218 polymorphism in somatotropinomas nonfunctioning pituitary adenomas

, 2018
Apesar de amplamente estudados, os mecanismos envolvidos no processo de transformação neoplásica das células hipofisárias e na progressão desses tumores permanecem, ainda, pouco esclarecidos.
Amorim, Paulo Vinícius Gonçalves Holanda
core   +1 more source