Results 101 to 110 of about 2,946 (202)

Metabolism and Energy Expenditure, But Not Feeding or Glucose Tolerance, Are Impaired in Young Kiss1r KO Female Mice [PDF]

, 2016
Kisspeptin regulates reproduction via signaling through the receptor, Kiss1r, in GnRH neurons. However, both kisspeptin and Kiss1r are produced in several peripheral tissues, and recent studies have highlighted a role for kisspeptin signaling in ...
Garcia, Christian, Tolson, Kristen P, Delgado, Iris, Kauffman, Alexander S, Marooki, Nuha   +4 more
core   +1 more source

Kisspeptin signaling in astrocytes modulates the reproductive axis

The Journal of Clinical Investigation
Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons.
Encarnacion Torres, Giuliana Pellegrino, Melissa Granados-Rodríguez, Antonio C. Fuentes-Fayos, Inmaculada Velasco, Adrian Coutteau-Robles, Amandine Legrand, Marya Shanabrough, Cecilia Perdices-Lopez, Silvia Leon, Shel H. Yeo, Stephen M. Manchishi, Maria J. Sánchez-Tapia, Victor M. Navarro, Rafael Pineda, Juan Roa, Frederick Naftolin, Jesús Argente, Raúl M. Luque, Julie A. Chowen, Tamas L. Horvath, Vincent Prevot, Ariane Sharif, William H. Colledge, Manuel Tena-Sempere, Antonio Romero-Ruiz   +25 more
doaj   +1 more source

GPR54 (KISS1R) Transactivates EGFR to Promote Breast Cancer Cell Invasiveness

PLoS ONE, 2011
Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans. However, recent studies have demonstrated that an increase in KISS1 and GPR54 expression in human breast tumors ...
Zajac, Mateusz, Law, Jeffrey, Cvetkovic, Dragana Donna, Pampillo, Macarena, McColl, Lindsay, Pape, Cynthia, Di Guglielmo, Gianni M., Postovit, Lynne M., Babwah, Andy V., Bhattacharya, Moshmi   +9 more
openaire   +5 more sources

KISS1 and KISS1R are variably expressed in MSCs, OPCs, and tumor cell lines.

, 2016
Protein expression of the kisspeptin precursor KISS1 and the receptor KISS1R was investigated in primary MSCs (A) and OPCs (B). Specificity of the KISS1R antibody was confirmed by the addition of a blocking antigen (C).
Lorenz C. Hofbauer (759669), Sanjay Tiwari (1669654), Norbert Schütze (306441), Franz Jakob (133384), Claus C. Glüer (347285), Robert J. Tower (2736013), Andreas Brandl (668766), Marc Müller (2736016), Regina Ebert (133381), Andreas Beilhack (63291), Julia Dotterweich (2736019)   +10 more
core   +1 more source

Conformational Change in the Ligand-Binding Pocket via a KISS1R Mutation (P147L) Leads to Isolated Gonadotropin-Releasing Hormone Deficiency [PDF]

Context: Kisspeptin receptor (KISS1R) is expressed in hypothalamic gonadotropin-releasing hormone neurons and responsible for pubertal onset and reproductive functions. KISS1R mutations remain a rare cause of congenital hypogonadotropic hypogonadism (CHH)
Miura, Ayako, Shimizu, Koichiro, 10180267, Sakoda, Hideyuki, シミズ, コウイチロウ, Miyazato, Mikiya, サコダ, ヒデユキ, 70710903, 山口, 秀樹, 30169, 26397, 90711292, 三浦, 綾子, Yoshida, Morikatsu, 21852, Nakazato, Masamitsu, 清水, 浩一郎, 中里, 雅光, 迫田, 秀之, 21757, Yonekawa, Tadato, 21756, 30173, Yamaguchi, Hideki, ナカザト, マサミツ, ヤマグチ, ヒデキ, 10305097, ミウラ, アヤコ   +27 more
core   +1 more source

Exploring the impact of exogenous Kisspeptin-10 on ovarian follicular development and estrus behaviour in Lakhimi cows of Assam

Indian Journal of Animal Sciences
The present study was carried out to assess the influence of exogenous intravenous kisspeptin-10 on the follicular dynamics, hormonal profile, and expression pattern of KiSS1 and KiSS1R of Lakhimi cows of Assam during the estrus period.
ANUPAM DATTA, ANUBHA BARUAH, ARUNDHATI BORA, DEVOJYOTI DUTTA, JITENDRA GOSWAMI, DEEPAK BHUYAN, SUKANTA DAS   +6 more
doaj   +1 more source

Sensitivities of mRNA expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats

, 2010
Decreased activity of kisspeptin, the product of the hypothalamic Kiss1 gene, is the major cause of the suppression of reproductive function in subnutritional conditions.
Riyo Kinouchi, Shinobu Fujisawa, Toshiyuki Yasui, Takeshi Iwasa, Masahiro Murakami, Minoru Irahara, Toshiya Matsuzaki, Ganbat Gereltsetseg, Akira Kuwahara   +8 more
core   +1 more source

The role of placental kisspeptin in trophoblast invasion and migration: An assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta [PDF]

Context: There is mounting evidence implicating kisspeptin signalling in placental development and function. Aims: This study aimed to elucidate kisspeptin\u27s role in trophoblast invasion and migration using three experimental models.
Coall, D. A., Panting, E. N., Sartori, J. A., Weight, J. H., Smith, J. T.   +4 more
core   +1 more source

Expression of GnRH, Kisspeptin, and Their Specific Receptors in the Ovary and Uterus in Deslorelin-Treated Late-Prepubertal Bitches

Veterinary Sciences
In this study, the expression and localization of gonadotropin-releasing hormone (GnRH1) and kisspeptin (KISS1) and their specific receptors in canine ovarian and uterine tissues were investigated after the application of deslorelin acetate (Suprelorin®,
Muhammet Ali Karadağ, Aykut Gram, Sabine Schäfer-Somi, Selim Aslan, Duygu Kaya   +4 more
doaj   +1 more source

KISS1R receptor (KISS1R; GPR54) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source