Results 101 to 110 of about 2,756 (195)

Expression of functional KISS1 and KISS1R system is altered in human pituitary adenomas: evidence for apoptotic action of kisspeptin-10.

, 2011
CONTEXT: KISS1 was originally identified as a metastasis-suppressor gene able to inhibit tumor progression. KISS1 gene products, the kisspeptins, bind to a G-protein-coupled receptor (KISS1R, formerly GPR54), which is highly expressed in placenta ...
Luque R. M., ZATELLI, Maria Chiara, Moreno Fernández J., Jiménez Reina L., Resmini E., DEGLI UBERTI, Ettore, Benito López P., Malagón M. M., Castaño J. P., Molina M., Leal Cerro A., Diéguez C., Soto A., Quintero A., Martínez Fuentes A. J., Webb S. M., Vázquez Martínez R., Gahete M. D., de la Riva A.   +18 more
core   +2 more sources

GPR54 (KISS1R) Transactivates EGFR to Promote Breast Cancer Cell Invasiveness

PLoS ONE, 2011
Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans. However, recent studies have demonstrated that an increase in KISS1 and GPR54 expression in human breast tumors ...
Zajac, Mateusz, Law, Jeffrey, Cvetkovic, Dragana Donna, Pampillo, Macarena, McColl, Lindsay, Pape, Cynthia, Di Guglielmo, Gianni M., Postovit, Lynne M., Babwah, Andy V., Bhattacharya, Moshmi   +9 more
openaire   +5 more sources

Reduced voluntary wheel running behaviour in Kiss1r knockout mice

Physiology & Behavior
Kisspeptin and its receptor, Kiss1r, are novel players in the central balance of energy intake and expenditure. Recent evidence also indicates that kisspeptin signalling is important in thermoregulation and generation of the circadian rhythm. We used global Kiss1r knockout mice (Kiss1r KO), which are hypogonadal and develop obesity, to determine the ...
Raj Patel, Aaron Gomes, Shane K Maloney, Jeremy T Smith   +3 more
openaire   +2 more sources

Genetic Variations of theKISS1RGene in Korean Girls with Central Precocious Puberty

Journal of Korean Medical Science, 2017
The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study aimed to identify the kisspeptin receptor (KISS1R) gene variations and to investigate the associations between these variations and central precocious puberty (CPP).
Yeon Joung Oh, Young-Jun Rhie, Hyo-Kyoung Nam, Hye Ryun Kim, Kee-Hyoung Lee   +4 more
openaire   +2 more sources

Metabolism and Energy Expenditure, But Not Feeding or Glucose Tolerance, Are Impaired in Young Kiss1r KO Female Mice [PDF]

, 2016
Kisspeptin regulates reproduction via signaling through the receptor, Kiss1r, in GnRH neurons. However, both kisspeptin and Kiss1r are produced in several peripheral tissues, and recent studies have highlighted a role for kisspeptin signaling in ...
Garcia, Christian, Tolson, Kristen P, Delgado, Iris, Kauffman, Alexander S, Marooki, Nuha   +4 more
core   +1 more source

Kisspeptin signaling in astrocytes modulates the reproductive axis

The Journal of Clinical Investigation
Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons.
Encarnacion Torres, Giuliana Pellegrino, Melissa Granados-Rodríguez, Antonio C. Fuentes-Fayos, Inmaculada Velasco, Adrian Coutteau-Robles, Amandine Legrand, Marya Shanabrough, Cecilia Perdices-Lopez, Silvia Leon, Shel H. Yeo, Stephen M. Manchishi, Maria J. Sánchez-Tapia, Victor M. Navarro, Rafael Pineda, Juan Roa, Frederick Naftolin, Jesús Argente, Raúl M. Luque, Julie A. Chowen, Tamas L. Horvath, Vincent Prevot, Ariane Sharif, William H. Colledge, Manuel Tena-Sempere, Antonio Romero-Ruiz   +25 more
doaj   +1 more source

Exploring the impact of exogenous Kisspeptin-10 on ovarian follicular development and estrus behaviour in Lakhimi cows of Assam

Indian Journal of Animal Sciences
The present study was carried out to assess the influence of exogenous intravenous kisspeptin-10 on the follicular dynamics, hormonal profile, and expression pattern of KiSS1 and KiSS1R of Lakhimi cows of Assam during the estrus period.
ANUPAM DATTA, ANUBHA BARUAH, ARUNDHATI BORA, DEVOJYOTI DUTTA, JITENDRA GOSWAMI, DEEPAK BHUYAN, SUKANTA DAS   +6 more
doaj   +1 more source

Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility

Iranian South Medical Journal, 2017
Background: Infertility referes to the inability of a couple to conceive over an average period of one year with unprotected sexual intercourse. In mammals, Fertility is initiated at puberty by the pulsatile secretion of gonadotrophin releasing hormone ...
Azadeh Poursharif, Hamidreza Vaziri, Toba Mirzapour   +2 more
doaj  

Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat

, 2009
Identification of kisspeptin (Kiss1) and its G protein-coupled receptor 54 (Kiss1r) as an essential component of the hypothalamic-pituitary-gonadal (HPG) axis controlling gonadotrophin secretion raises the possibility that kisspeptin-Kiss1r signalling ...
Kinsey-Jones, J. S., Wilkinson, E. S., Chaudhary, A A, Li, X. F., O'Byrne, K T, Lightman, S. L., Milligan, S. R., Lightman, S L, O'Byrne, K. T., Knox, A M I, Li, X F, Wilkinson, E S, Zhu, X. L., Knox, A. M. I., Kinsey-Jones, J S, Chaudhary, A. A., Zhu, X L, Milligan, S R   +17 more
core   +1 more source

KISS1R receptor (KISS1R; GPR54) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source