Results 31 to 40 of about 2,946 (202)
Lower FSH With Normal Fertility in Male Mice Lacking Gonadotroph Kisspeptin Receptor
Frontiers in Physiology, 2022 The kisspeptin receptor, crucial for hypothalamic control of puberty and reproduction, is also present in the pituitary gland. Its role in the pituitary gland is not defined.
Yaping Ma +9 more
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Genetic variants of G‐protein coupled receptors associated with pubertal disorders
Reproductive Medicine and Biology, 2023 Background The human hypothalamic–pituitary‐gonadal (HPG) axis is the regulatory center for pubertal development. This axis involves six G‐protein coupled receptors (GPCRs) encoded by KISS1R, TACR3, PROKR2, GNRHR, LHCGR, and FSHR.
Erina Suzuki +3 more
doaj +1 more source
Does kisspeptin exert a local modulatory effect on bovine ovarian steroidogenesis?
Reproduction and Fertility, 2023 Kisspeptin, a hypothalamic neuropeptide encoded by the KISS1 gene, has a pivotal role in promoting gonadotrophin-releasing hormone secretion in mammals.
Dareen Mattar +3 more
doaj +1 more source
Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype [PDF]
, 2019 Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity ...
Tolson, Kristen P +4 more
core +1 more source
KISS1R signaling modulates gonadotropin sensitivity in mouse Leydig cell [PDF]
Reproduction, 2020 Abstract Kisspeptin and its receptor KISS1R have been proven as pivotal regulators on controlling the hypothalamus–pituitary–gonad axis. Inactivating mutations in one of them cause idiopathic hypogonadotropic hypogonadism in human as well as rodent models.
Meng-Chieh Hsu +3 more
openaire +2 more sources
Kisspeptins inhibit human airway smooth muscle proliferation
JCI Insight, 2022 Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous role for estrogen in airway remodeling, making it unclear whether sex hormones are protective or ...
Niyati A. Borkar +5 more
doaj +1 more source
Silent Mutation in KISS1 and KISS1R and Unexplained Infertility [PDF]
Avicenna Journal of Medical Biochemistry, 2015 Kisspeptin (KP) is a set of peptides coded by the KISS1 gene that is a metastasis suppressor gene located on chromosome 1q32. It plays an important role in regulation of hypothalamic-pituitary-gonadal axis (1). The association of KP with the disruption of hypothalamic-pituitarygonadal axis, can be exemplified by high concordance of the phenotypes ...
Rehman, Jamil, Fatima, Alam
doaj +2 more sources
, 2022 Kisspeptin, produced from the brain and peripheral tissues, may constitute an important link in metabolic regulation in response to external cues, such as diet. The kisspeptin system is well described in the brain. However, its function and regulation in
Maciej Sassek (13774528) +8 more
core +1 more source
Endokrynologia Polska, 2021 INTRODUCTION: Pituitary neuroendocrine tumours (PitNETs), traditionally designated as pituitary adenomas, show elatively frequent invasive growth with exceptional metastatic potential, the causes of which are not entirely elucidated.
Milena Mihajlovic +13 more
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PRR repeats in the intracellular domain of KISS1R are important for its export to cell membrane.: PRR repeats in intracellular domain of KISSIR [PDF]
, 2013 The National Institute of Health and Medical Research (INSERM, France) The Ministry of Research (France) The University Paris Diderot, Sorbonne Paris Cite (France) The National Institute of Blood Transfusion (INTS, France) The Laboratories of Excellence,
de Brevern, Alexandre +6 more
core +1 more source