Results 31 to 40 of about 2,756 (195)

Kisspeptin and KISS1R: a critical pathway in the reproductive system [PDF]

Reproduction, 2008
Abstract In 2003, three groups around the world simultaneously discovered that KISS1R (GPR54) is a key gatekeeper of sexual maturation in both mice and men. Developmental changes in the expression of the ligand for KISS1R, kisspeptin, support its critical role in the pubertal transition. In addition, kisspeptin, a powerful stimulus of
Elena, Gianetti, Stephanie, Seminara
openaire   +2 more sources

Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model

The Journal of Clinical Investigation, 2022
Nonalcoholic fatty liver disease (NAFLD), the most common liver disease, has become a silent worldwide pandemic. The incidence of NAFLD correlates with the rise in obesity, type 2 diabetes, and metabolic syndrome.
Stephania Guzman, Magdalena Dragan, Hyokjoon Kwon, Vanessa de Oliveira, Shivani Rao, Vrushank Bhatt, Katarzyna M. Kalemba, Ankit Shah, Vinod K. Rustgi, He Wang, Paul R. Bech, Ali Abbara, Chioma Izzi-Engbeaya, Pinelopi Manousou, Jessie Y. Guo, Grace L. Guo, Sally Radovick, Waljit S. Dhillo, Fredric E. Wondisford, Andy V. Babwah, Moshmi Bhattacharya   +20 more
doaj   +1 more source

DNA hypermethylation of Kiss1r promoter and reduction of hepatic Kiss1r in female rats with type 2 diabetes

, 2022
Kisspeptin, produced from the brain and peripheral tissues, may constitute an important link in metabolic regulation in response to external cues, such as diet. The kisspeptin system is well described in the brain. However, its function and regulation in
Maciej Sassek (13774528), Emilia Grzeda (13774531), Yuexi Ma (12492382), Kamil Ziarniak (13774525), Megan Beetch (5044328), Joanna H. Sliwowska (13774534), Cayla Boycott (12492379), Barbara Stefanska (443027), Tony Yang (7256420)   +8 more
core   +1 more source

Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System [PDF]

Endocrinology and Metabolism, 2016
Kisspeptin signaling at the gonadotropin-releasing hormone (GnRH) neuron is now relatively well characterized and established as being critical for the neural control of fertility.
Xinhuai Liu, Allan E. Herbison
doaj   +1 more source

Relative expression profile of Kisspeptin (Kiss1-Kiss1r) and gonadotrophin receptor in the ovarian follicular tissue and their association in the Buffalo (Bubalus bubalis)

Indian Journal of Animal Sciences, 2022
In the past decade, kisspeptin research was primarily focussed on the regulation of GnRH release in hypothalamus. Present study was designed to explore the expression of extra-hypothalamic kisspeptinergic (Kiss1- Kiss1r) system in the follicular ...
Girish Kumar Mishra, Manas Patra Kumar, Laishram Kipjen Singh, Vikramaditya Upmanyu, Soumendu Chakravarti, Mathesh Karikalan, Manjit Panigrahi, Sanjay Kumar Singh, Goutam Kumar Das, Krishnaswamy Narayanan, Harendra Kumar   +10 more
doaj   +1 more source

Lower FSH With Normal Fertility in Male Mice Lacking Gonadotroph Kisspeptin Receptor

Frontiers in Physiology, 2022
The kisspeptin receptor, crucial for hypothalamic control of puberty and reproduction, is also present in the pituitary gland. Its role in the pituitary gland is not defined.
Yaping Ma, Yaping Ma, Olubusayo Awe, Sally Radovick, Xiaofeng Yang, Sara Divall, Andrew Wolfe, Sheng Wu, Sheng Wu, Sheng Wu   +9 more
doaj   +1 more source

KISS1R signaling modulates gonadotropin sensitivity in mouse Leydig cell [PDF]

Reproduction, 2020
Abstract Kisspeptin and its receptor KISS1R have been proven as pivotal regulators on controlling the hypothalamus–pituitary–gonad axis. Inactivating mutations in one of them cause idiopathic hypogonadotropic hypogonadism in human as well as rodent models.
Meng-Chieh Hsu, Leang-Shin Wu, De-Shien Jong, Chih-Hsien Chiu   +3 more
openaire   +2 more sources

Genetic variants of G‐protein coupled receptors associated with pubertal disorders

Reproductive Medicine and Biology, 2023
Background The human hypothalamic–pituitary‐gonadal (HPG) axis is the regulatory center for pubertal development. This axis involves six G‐protein coupled receptors (GPCRs) encoded by KISS1R, TACR3, PROKR2, GNRHR, LHCGR, and FSHR.
Erina Suzuki, Mami Miyado, Yoko Kuroki, Maki Fukami   +3 more
doaj   +1 more source

Metastasierungsspezifische Veränderungen im DNA-Methylierungsmuster von KISS1R und EPHB3 im muskelinvasiven Harnblasenkarzinom [PDF]

, 2023
Die epigenetische Inaktivierung von Genen durch Promotorhypermethylierung kann zur Entstehung und Metastasierung von Tumoren beitragen. Veränderungen im DNA-Methylierungsmuster gelten als hoch sensitiv und sind bereits frühzeitig nachweisbar.
Swienty, Anja Nathalie
core   +1 more source

Does kisspeptin exert a local modulatory effect on bovine ovarian steroidogenesis?

Reproduction and Fertility, 2023
Kisspeptin, a hypothalamic neuropeptide encoded by the KISS1 gene, has a pivotal role in promoting gonadotrophin-releasing hormone secretion in mammals.
Dareen Mattar, Warakorn Cheewasopit, Moafaq Samir, Phil G Knight   +3 more
doaj   +1 more source