Results 21 to 30 of about 2,946 (202)

LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty [PDF]

BMC Research Notes, 2011
Background Pubertal timing is a strongly heritable trait, but no single puberty gene has been identified. Thus, the genetic background of idiopathic central precocious puberty (ICPP) is poorly understood. Overall, the genetic modulation of pubertal onset
Koivu Rosanna, Aksglaede Lise, Sørensen Kaspar, Tommiska Johanna, Puhakka Lea, Juul Anders, Raivio Taneli   +6 more
doaj   +4 more sources

Puberty-Associated Changes in Kiss1r, MC3R, and MC4R in the Ewe [PDF]

The neural mechanisms that control the onset of puberty are not completely understood. In livestock, the onset of puberty relies on an increase in gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH). Kisspeptin, neurokinin B, and dynorphin
Thomson, Ashleigh Caitlyn
openaire   +2 more sources

Expressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches. [PDF]

Reprod Domest Anim
ABSTRACT Kisspeptin is a peptide that plays a pivotal role in the central regulation of gonadotropins. It is regarded as a key regulator of reproductive processes, including follicular and luteal development and endometrial remodelling. The objective of this study was to investigate the expression of KISS1, its receptor KISS1R and the proliferation ...
Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Özmen Ö, Bozkurt G, Taşan Ş.   +4 more
europepmc   +2 more sources

RF9 Acts as a KISS1R Agonist In Vivo and In Vitro [PDF]

Endocrinology, 2015
RF9, a reported antagonist of the mammalian gonadotropin-inhibitory hormone receptor, stimulates gonadotropin secretion in mammals. Recent studies have suggested that the stimulatory effect of RF9 on gonadotropin secretion relies on intact kisspeptin receptor (KISS1R) signaling, but the underlying mechanisms remain to be elucidated.
Min, L, Leon, S, Li, H, Pinilla, L, Carroll, RS, Tena-Sempere M, Kaiser, UB   +6 more
openaire   +5 more sources

MKRN3 and KISS1R mutations in precocious and early puberty [PDF]

Italian Journal of Pediatrics, 2020
Abstract Background Pubertal timing is known to be influenced by interactions among various genetic, nutritional, environmental and socio-economic factors, although the ultimate mechanisms underlying the increase in pulsatile GnRH secretion at puberty have yet to be fully elucidated.
Pagani, Sara, Calcaterra, Valeria, Acquafredda, Gloria, Montalbano, Chiara, Bozzola, Elena, Ferrara, Pietro, Gasparri, Manuela, Villani, Alberto, Bozzola, Mauro   +8 more
openaire   +5 more sources

Kisspeptin/KISS1R System in Breast Cancer [PDF]

Journal of Cancer, 2013
Kisspeptins (KP), peptide products of the kisspeptin-1 (KISS1) gene are the endogenous ligands for a G protein-coupled receptor (GPCR) - KP receptor (KISS1R). KISS1R couples to the Gαq/11 signaling pathway. KISS1 is a metastasis suppressor gene and the KP/KISS1R signaling has anti-metastatic and tumor-suppressant effects in numerous human cancers.
Cvetković, Donna, Babwah, Andy V., Bhattacharya, Moshmi   +2 more
openaire   +2 more sources

Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility

Iranian South Medical Journal, 2017
Background: Infertility referes to the inability of a couple to conceive over an average period of one year with unprotected sexual intercourse. In mammals, Fertility is initiated at puberty by the pulsatile secretion of gonadotrophin releasing hormone ...
Azadeh Poursharif, Hamidreza Vaziri, Toba Mirzapour   +2 more
doaj   +1 more source

Kisspeptin and KISS1R: a critical pathway in the reproductive system [PDF]

Reproduction, 2008
Abstract In 2003, three groups around the world simultaneously discovered that KISS1R (GPR54) is a key gatekeeper of sexual maturation in both mice and men. Developmental changes in the expression of the ligand for KISS1R, kisspeptin, support its critical role in the pubertal transition. In addition, kisspeptin, a powerful stimulus of
Elena, Gianetti, Stephanie, Seminara
openaire   +2 more sources

KISS1R polymorphism rs587777844 (Tyr313His) is linked to female infertility

British Journal of Biomedical Science, 2021
Infertility is a reproductive system disorder, defined as the failure to become pregnant after 12 months of regular, unprotected intercourse, or to produce a viable infant [1,2].
Z Siahpoosh, M Farsimadan, M Pazhohan, H Vaziri, M Mahmoudi Gomari   +4 more
openaire   +3 more sources

Relative expression profile of Kisspeptin (Kiss1-Kiss1r) and gonadotrophin receptor in the ovarian follicular tissue and their association in the Buffalo (Bubalus bubalis)

Indian Journal of Animal Sciences, 2022
In the past decade, kisspeptin research was primarily focussed on the regulation of GnRH release in hypothalamus. Present study was designed to explore the expression of extra-hypothalamic kisspeptinergic (Kiss1- Kiss1r) system in the follicular ...
Girish Kumar Mishra, Manas Patra Kumar, Laishram Kipjen Singh, Vikramaditya Upmanyu, Soumendu Chakravarti, Mathesh Karikalan, Manjit Panigrahi, Sanjay Kumar Singh, Goutam Kumar Das, Krishnaswamy Narayanan, Harendra Kumar   +10 more
doaj   +1 more source