Results 31 to 40 of about 7,724 (208)
Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. [PDF]
PLoS ONE, 2014 KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging ...
Sitaram Harihar +4 more
doaj +1 more source
Inactivating KISS1 Mutation and Hypogonadotropic Hypogonadism [PDF]
Obstetrical & Gynecological Survey, 2012 Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B stimulate GnRH release. Inactivating mutations in the genes encoding the human kisspeptin receptor (KISS1R, formerly called GPR54), neurokinin B (TAC3), and the neurokinin B ...
Topaloglu, A. Kemal +9 more
openaire +3 more sources
Frontiers in Oncology, 2023 Metastatic dissemination is still one of the major causes of death of melanoma’s patients. KiSS1 is a metastasis suppressor originally identified in melanoma cells, known to play an important physiological role in mammals’ development and puberty. It has
Carlotta Guzzetti +7 more
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Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice
Nature Communications, 2023 Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exerting a surge-
Jose M. Ramos-Pittol +14 more
doaj +1 more source
Association of the KiSS1 gene with litter size in Cyprus and Iraqi black goats [PDF]
Veterinary World, 2021 Aim: The study investigated the genetic polymorphism of the kisspeptin (KiSS1) gene and its relationship with litter size in Cyprus and Iraqi black goats.
M. A. Rahawy +1 more
doaj +1 more source
Upregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1. [PDF]
PLoS ONE, 2014 Ubiquitin-like with PHD and RING finger domains 1 (UHRF1), as an epigenetic regulator, plays important roles in the tumorigenesis and cancer progression.
Yu Zhang +7 more
doaj +1 more source
Transcriptional regulation of the human KiSS1 gene [PDF]
Molecular and Cellular Endocrinology, 2011 Kisspeptin, the product of the KiSS1 gene, has emerged as a key component of the mechanism by which the hypothalamus controls puberty and reproductive development. It does so by stimulating the secretion of gonadotropin releasing hormone (GnRH). Little is known about the transcriptional control of the KiSS1 gene.
Johanna K, Mueller +8 more
openaire +2 more sources
Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2
eLife, 2021 Hypothalamic Kiss1 neurons control gonadotropin-releasing hormone release through the secretion of kisspeptin. Kiss1 neurons serve as a nodal center that conveys essential regulatory cues for the attainment and maintenance of reproductive function ...
Silvia Leon +11 more
doaj +1 more source
Scientific Reports, 2023 The gonadotropin-releasing hormone (GnRH) pulse and surge are considered to be generated by arcuate kisspeptin/neurokinin B/dynorphin A (KNDy) neurons and anteroventral periventricular nucleus (AVPV) kisspeptin neurons, respectively, in female rodents ...
Mayuko Nagae +13 more
doaj +1 more source
EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression
Cell Communication and Signaling, 2021 Background During pregnancy, trophoblast cell invasion needs to be finely controlled. Aberrant trophoblast cell invasion is associated with placental diseases.
Lanlan Fang +7 more
doaj +1 more source