Results 11 to 20 of about 8,886 (197)

KISS1/KISS1R in Cancer: Friend or Foe? [PDF]

Frontiers in Endocrinology, 2018
The KISS1 gene encodes KISS1, a protein that is rapidly processed in serum into smaller but biologically active peptides called kisspeptins (KPs). KISS1 and the KPs signal via the G-protein coupled receptor KISS1R.
Stephania Guzman, Stephania Guzman, Muriel Brackstone, Sally Radovick, Sally Radovick, Andy V. Babwah, Andy V. Babwah, Moshmi M. Bhattacharya, Moshmi M. Bhattacharya, Moshmi M. Bhattacharya   +9 more
doaj   +4 more sources

Gallium-68-Labeled KISS1-54 Peptide for Mapping KISS1 Receptor via PET: Initial Evaluation in Human Tumor Cell Lines and in Tumor-Bearing Mice

Pharmaceuticals, 2023
Kisspeptins (KPs, KISS1) and their receptor (KISS1R) play a pivotal role as metastasis suppressor for many cancers. Low or lost KP expression is associated with higher tumor grade, increased metastatic potential, and poor prognosis.
Ina Israel, Gabriele Riehl, Elke Butt, Andreas K. Buck, Samuel Samnick   +4 more
doaj   +2 more sources

GnRH-Deficient Phenotypes in Humans and Mice With Heterozygous Variants in KISS1/Kiss1 [PDF]

Obstetrical & Gynecological Survey, 2011
No description ...
YM Chan, S Broder-Fingert, S Paraschos, R Lapatto, M Au, V Hughes, SD Bianco, L Min, L Plummer, F Cerrato, A DeGuillebon, IH Wu, F Wahab, A Dwyer, S Kirsch, R Quinton, Timothy Cheetham, M Ozata, S Ten, JP Chanoine, N Pitteloud, KA Martin, R Schiffmann, HJ VanderKamp, S Nader, JE Hall, UB Kaiser, SB Seminara   +27 more
openaire   +5 more sources

CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait

Frontiers in Genetics, 2023
Introduction: Most male pigs are surgically castrated to avoid puberty-derived boar taint and aggressiveness. However, this surgical intervention represents a welfare concern in swine production.
Julio M. Flórez, Julio M. Flórez, Kyra Martins, Staci Solin, Jonathan R. Bostrom, Paula Rodríguez-Villamil, Felipe Ongaratto, Sabreena A. Larson, Uyanga Ganbaatar, Alexander W. Coutts, Doug Kern, Thomas W. Murphy, Eui-Soo Kim, Daniel F. Carlson, Abe Huisman, Tad S. Sonstegard, Clay A. Lents   +16 more
doaj   +2 more sources

Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice [PDF]

Nature Communications, 2022
Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of ...
Juan Roa, Miguel Ruiz-Cruz, Francisco Ruiz-Pino, Rocio Onieva, Maria J. Vazquez, Maria J. Sanchez-Tapia, Jose M. Ruiz-Rodriguez, Veronica Sobrino, Alexia Barroso, Violeta Heras, Inmaculada Velasco, Cecilia Perdices-Lopez, Claes Ohlsson, Maria Soledad Avendaño, Vincent Prevot, Matti Poutanen, Leonor Pinilla, Francisco Gaytan, Manuel Tena-Sempere   +18 more
doaj   +3 more sources

Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice

The Journal of Reproduction and Development, 2020
The present study aimed to evaluate whether novel conditional kisspeptin neuron-specific Kiss1 knockout (KO) mice utilizing the Cre-loxP system could recapitulate the infertility of global Kiss1 KO models, thereby providing further evidence for the ...
Kana IKEGAMI, Teppei GOTO, Sho NAKAMURA, Youki WATANABE, Arisa SUGIMOTO, Sutisa MAJARUNE, Kei HORIHATA, Mayuko NAGAE, Junko TOMIKAWA, Takuya IMAMURA, Makoto SANBO, Masumi HIRABAYASHI, Naoko INOUE, Kei-ichiro MAEDA, Hiroko TSUKAMURA, Yoshihisa UENOYAMA   +15 more
doaj   +4 more sources

Inactivating KISS1 Mutation and Hypogonadotropic Hypogonadism [PDF]

Obstetrical & Gynecological Survey, 2012
Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B stimulate GnRH release. Inactivating mutations in the genes encoding the human kisspeptin receptor (KISS1R, formerly called GPR54), neurokinin B (TAC3), and the neurokinin B ...
Topaloglu, A. Kemal, Tello, Javier A., Kotan, L. Damla, Ozbek, Mehmet N., Yilmaz, M. Bertan, Erdogan, Seref, Gurbuz, Fatih, Temiz, Fatih, Millar, Robert P., Yuksel, Bilgin   +9 more
core   +5 more sources

Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats

The Journal of Reproduction and Development
Hypothalamic arcuate (ARC) kisspeptin neurons are considered the gonadotropin-releasing hormone pulse generator in rats. In virgin rats, the expression of the ARC kisspeptin gene (Kiss1) is repressed by proestrous levels of estradiol-17β (high E2) but ...
Marina TAKIZAWA, Sae MIYAZAKI, Hitomi TSUCHIDA, Mayuko NAGAE, Shunsuke SEKI, Masumi HIRABAYASHI, Fumitaka OSAKADA, Naoko INOUE, Hiroko TSUKAMURA, Yoshihisa UENOYAMA   +9 more
doaj   +2 more sources

Análise da expressão do KISS1/KISS1  do polimorfismo rs5780218 KISS1 em somatotropinomas e adenomas hipofisários clinicamente não funcionantes [PDF]

, 2019
Apesar de amplamente estudados, os mecanismos envolvidos no processo de transformação neoplásica das células hipofisárias e na progressão desses tumores permanecem, ainda, pouco esclarecidos.
Amorim, Paulo Vinícius Gonçalves Holanda
openaire   +2 more sources

Reversibility and safety of KISS1 metastasis suppressor gene vaccine in immunocastration of ram lambs [PDF]

Asian-Australasian Journal of Animal Sciences, 2018
Objective The aim of this study was to investigate the reversibility and safety of KISS1 metastasis suppressor (KISS1) gene vaccine in immunocastration. Methods Six eight-week old ram lambs were randomly divided into vaccinated and control groups.
Yan-Guo Han, Gui-Qiong Liu, Xun-Ping Jiang, Xing-Long Xiang, Yong-Fu Huang, Bin Nie, Jia-Yu Zhao, Ijaz Nabeel, Birhanu Tesema   +8 more
doaj   +3 more sources