Results 11 to 20 of about 8,330 (205)

KISS1/KISS1R in Cancer: Friend or Foe? [PDF]

Frontiers in Endocrinology, 2018
The KISS1 gene encodes KISS1, a protein that is rapidly processed in serum into smaller but biologically active peptides called kisspeptins (KPs). KISS1 and the KPs signal via the G-protein coupled receptor KISS1R.
Stephania Guzman, Stephania Guzman, Muriel Brackstone, Sally Radovick, Sally Radovick, Andy V. Babwah, Andy V. Babwah, Moshmi M. Bhattacharya, Moshmi M. Bhattacharya, Moshmi M. Bhattacharya   +9 more
doaj   +4 more sources

Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse. [PDF]

Journal of Neuroendocrinology, 2016
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in the regulation of the mammalian reproductive axis. Kiss1 neurones are found in two locations in the rodent hypothalamus: one in the arcuate nucleus (ARC) and another in ...
Morris, PG, Sinnett-Smith, LC, Schacker, M, Colledge, W. H., Kyle, V, Jackman, S, Yeo, SH, Chen, C   +7 more
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GnRH-Deficient Phenotypes in Humans and Mice with Heterozygous Variants inKISS1/Kiss1 [PDF]

Obstetrical & Gynecological Survey, 2011
Context: KISS1 is a candidate gene for GnRH deficiency. Objective: Our objective was to identify deleterious mutations in KISS1. Patients and Methods: DNA sequencing and assessment of the effects of rare sequence variants (RSV) were conducted in 1025 ...
I-Hsuan Wu, Nader, Shahla, Van der Kamp, H.J., Broder-Fingert, Sarabeth, Kaiser, Ursula B, Min, L., Lapatto, R., Felecia Cerrato, Hall, J.E., Dwyer, A., Kaiser, U.B., Au, Margaret, Kirsch, S., Sarabeth Broder-Fingert, Wahab, Fazal, Ozata, Metin, Schiffmann, Raphael, Metin Ozata, Ozata, M., Quinton, Richard, Risto Lapatto, De Guillebon, Adelaide, Wu, I.H., Bianco, S.D., Lacey Plummer, Plummer, L., Ten, S., Susan Kirsch, Min, Le, Kirsch, Susan, Van der Kamp, Hetty J, Hall, Janet E, Paraschos, S., Virginia Hughes, Raphael Schiffmann, Au, M., Chan, Yee-Ming, Pitteloud, Nelly, Shahla Nader, Nelly Pitteloud, Hughes, Virginia, Nader, S., Seminara, S.B., Cerrato, Felecia, Cerrato, F., Quinton, R., Ten, Svetlana, Wu, I-Hsuan, Chanoine, Jean-Pierre, Suzy D. C. Bianco, Martin, Kathryn A, Paraschos, Sophia, Sophia Paraschos, Richard Quinton, Martin, K.A., Janet E. Hall, Schiffmann, R., Pitteloud, N., Fazal Wahab, Broder-Fingert, S., Cheetham, T., Jean-Pierre Chanoine, Chan, Y.M., Hughes, V., Hetty J. Van der Kamp, Seminara, Stephanie B, Ursula B. Kaiser, Wahab, F., Svetlana Ten, Yee-Ming Chan, Le Min, Stephanie B. Seminara, De Guillebon, A., Kathryn A. Martin, Timothy Cheetham, Chanoine, J.P., Lapatto, Risto, Plummer, Lacey, Margaret Au, Adelaide De Guillebon, Andrew Dwyer, Dwyer, Andrew, Bianco, Suzy D. C, Cheetham, Timothy   +83 more
core   +4 more sources

Gallium-68-Labeled KISS1-54 Peptide for Mapping KISS1 Receptor via PET: Initial Evaluation in Human Tumor Cell Lines and in Tumor-Bearing Mice

Pharmaceuticals, 2023
Kisspeptins (KPs, KISS1) and their receptor (KISS1R) play a pivotal role as metastasis suppressor for many cancers. Low or lost KP expression is associated with higher tumor grade, increased metastatic potential, and poor prognosis.
Ina Israel, Gabriele Riehl, Elke Butt, Andreas K. Buck, Samuel Samnick   +4 more
doaj   +2 more sources

Redundancy in Kiss1 expression safeguards reproduction in the mouse [PDF]

Endocrinology, 2013
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a prerequisite for puberty and reproduction.
Moriyama, Ryutaro M., Navarro, Victor M., Steiner, Robert A, Seminara, Stephanie B., Popa, Simina M., Concepcion, Tessa L., Clifton, Donald K., Chan, Yee-Ming, Sanz, Elisenda, Yang, Jasmine J., Oakley, Amy E., Caligioni, Claudia S., Lee, In Hae, Palmiter, Richard D., Amieux, Paul S., Cho, Caroline M., Caraty, Alain   +16 more
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Investigation of KISS1/KISS1R gene expression and KISS1 rs5780218 polymorphism in somatotropinomas nonfunctioning pituitary adenomas [PDF]

, 2018
Apesar de amplamente estudados, os mecanismos envolvidos no processo de transformação neoplásica das células hipofisárias e na progressão desses tumores permanecem, ainda, pouco esclarecidos.
Amorim, Paulo Vinícius Gonçalves Holanda
core   +2 more sources

Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice [PDF]

Nature Communications, 2022
Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of ...
Juan Roa, Miguel Ruiz-Cruz, Francisco Ruiz-Pino, Rocio Onieva, Maria J. Vazquez, Maria J. Sanchez-Tapia, Jose M. Ruiz-Rodriguez, Veronica Sobrino, Alexia Barroso, Violeta Heras, Inmaculada Velasco, Cecilia Perdices-Lopez, Claes Ohlsson, Maria Soledad Avendaño, Vincent Prevot, Matti Poutanen, Leonor Pinilla, Francisco Gaytan, Manuel Tena-Sempere   +18 more
doaj   +3 more sources

KiSS1 inhibits growth and invasion of osteosarcoma cells through inhibition of the MAPK pathway

European Journal of Histochemistry, 2013
As a metastasis suppressor, KiSS1 has been implicated in numerous human cancers. However, recent studies have demonstrated that KiSS1 promotes tumor growth and metastasis in breast cancer, and it is unclear about the expression and function of KiSS1 in ...
Y. Zhang, Y.J. Tang, Z.H. Li, F. Pan, K. Huang, G.H. Xu   +5 more
doaj   +2 more sources

Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2 [PDF]

eLife, 2021
Hypothalamic Kiss1 neurons control gonadotropin-releasing hormone release through the secretion of kisspeptin. Kiss1 neurons serve as a nodal center that conveys essential regulatory cues for the attainment and maintenance of reproductive function ...
Silvia Leon, Rajae Talbi, Elizabeth A McCarthy, Kaitlin Ferrari, Chrysanthi Fergani, Lydie Naule, Ji Hae Choi, Rona S Carroll, Ursula B Kaiser, Carlos F Aylwin, Alejandro Lomniczi, Víctor M Navarro   +11 more
doaj   +2 more sources

CHARACTERIZATION OF Kiss1 NEURONS USING TRANSGENIC MOUSE MODELS [PDF]

Neuroscience, 2011
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism.
MARGATHO, L. O., ROVINSKY, S., GAUTRON, L., CRAVO, R. M., FRAZAO, R., BOOKOUT, A. L., DONATO JR., J., ZIGMAN, J. M., ELIAS, C. F., OSBORNE-LAWRENCE, S., ATKIN, S., LEE, C. E.   +11 more
core   +3 more sources