The Journal of Reproduction and Development, 2023 Hypothalamic kisspeptin neurons are master regulators of mammalian reproduction via direct stimulation of gonadotropin-releasing hormone and consequent gonadotropin release.
Koki YAMADA +10 more
doaj +3 more sources
The Journal of Reproduction and Development, 2020 The present study aimed to evaluate whether novel conditional kisspeptin neuron-specific Kiss1 knockout (KO) mice utilizing the Cre-loxP system could recapitulate the infertility of global Kiss1 KO models, thereby providing further evidence for the ...
Kana IKEGAMI +15 more
doaj +3 more sources
Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents
The Journal of Reproduction and Development, 2020 Kisspeptin, encoded by Kiss1, is essential for reproduction in mammals. Kiss1 expression is regulated by estrogen via histone acetylation in the Kiss1 promotor region.
Kei HORIHATA +4 more
doaj +3 more sources
Developmental Profile and Sexually Dimorphic Expression of Kiss1 and Kiss1r in the Fetal Mouse Brain [PDF]
Frontiers in Endocrinology, 2013 The hypothalamic-pituitary-gonadal axis (HPG) is a complex neuroendocrine circuit involving multiple levels of regulation. Kisspeptin neurons play essential roles in controlling the HPG axis from the perspectives of puberty onset, oscillations of ...
John Gabriel Knoll +6 more
doaj +2 more sources
Effects of prenatal stress on reproductive function of male offspring through the KISS1 system
Endocrine ConnectionsPrenatal stress can lead to the programming of the neuroendocrine system in male offspring, disrupting the hypothalamic testicular axis and adversely affecting the reproductive health of male offspring. This study aimed to determine the long-term effects
Jian Gong +5 more
doaj +2 more sources
GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice [PDF]
J NeuroendocrinolAbstract The arcuate nucleus kisspeptin (ARNKISS) neurons intermittently synchronize their activity to operate as the GnRH pulse generator and drive pulsatile reproductive hormone secretion in mammals. Although ARNKISS neurons are known to receive various GABAergic inputs, the effects of GABAA and GABAB receptor modulation on their ability to ...
Eddleston T, Morris P, Herbison A.
europepmc +2 more sources
KISS1/KISS1R in Cancer: Friend or Foe? [PDF]
Frontiers in Endocrinology, 2018 The KISS1 gene encodes KISS1, a protein that is rapidly processed in serum into smaller but biologically active peptides called kisspeptins (KPs). KISS1 and the KPs signal via the G-protein coupled receptor KISS1R.
Stephania Guzman +9 more
doaj +3 more sources
Regulation of Kiss1 Expression by Sex Steroids in the Amygdala of the Rat and Mouse [PDF]
Endocrinology, 2011 Joshua Kim +2 more
exaly +2 more sources
Hypothalamic Expression of KiSS1 and RFamide-related Peptide-3 mRNAs during The Estrous Cycle of Rats [PDF]
International Journal of Fertility and Sterility, 2013 Kisspeptin and RFamide-related peptide-3 (RFRP-3) are known to affect GnRH/luteinizing hormone (LH) in several species, including the rat. It has been hypothesized that GnRH/LH changes during the rat estrous cycle may result from changes in the ...
Mohammad Saied Salehi +9 more
doaj +2 more sources
Genetic and epigenetic aspects of the and genes in pubertal development and central precocious puberty: A review [PDF]
Precision and Future Medicine, 2023 The onset of puberty is a pivotal developmental milestone, and the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone is a key factor in the initiation of puberty. Both kisspeptin and its receptor (KISS1) and KISS1 receptor (KISS1R)
Ahreum Kwon
doaj +1 more source