Results 71 to 80 of about 2,975 (220)
New understandings of the genetic basis of isolated idiopathic central hypogonadism [PDF]
, 2012 Idiopathic hypogonadotropic hypogonadism is a rare disease that is characterized by delayed/absent puberty and/or infertility due to an insufficient stimulation of an otherwise normal pituitary-gonadal axis by gonadotrophin-releasing hormone (GnRH ...
Altobelli M +66 more
core +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.This study explores the potential of hyperoside to activate the estrogen‐PI3K/VEGF axis, thereby suppressing oxidative stress and enhancing osteogenic differentiation to mitigate osteoporosis. The initial proposal of the estrogen‐PI3K/VEGF signaling pathway axis as a potential therapeutic approach for osteoporosis.
Shuo Wang +8 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2022 Kisspeptins are involved in the regulation of hypothalamic-pituitary-gonadal axis, Leydig cell functions, and testosterone secretion, acting as endogenous ligands of the KISS1 receptor.
Giulia Ricci +12 more
doaj +1 more source
The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma. [PDF]
, 2012 The objective of this study was to use the established xenograft model of human melanoma (C8161.9) to test a pharmacological approach to the effect of the metastasis suppressor KISS1. A KISS1 analog was used to inhibit the metastatic development of C8161.
Evans, Barry +5 more
core +2 more sources
Frontiers in Neuroendocrinology, 2022 Kisspeptin, encoded by the KISS1 gene, was first discovered as a potential metastasis suppressor gene. The prepro-kisspeptin precursor is cleaved into shorter mature bioactive peptides of varying sizes that bind to the G protein-coupled receptor GPR54 (=KISS1R).
Mageswary Sivalingam, Ishwar S. Parhar
openaire +2 more sources
Journal of Neuroscience Research, Volume 104, Issue 4, April 2026.Six3 and Six6 are necessary for the development of the suprachiasmatic nucleus (SCN), and both remain expressed after SCN neurogenesis. We implemented a Neuromedin‐S (NMS)‐cre mouse model to conditionally knockout either Six3 or Six6 from the SCN to determine the post‐proliferative roles of these transcription factors in hypothalamic and circadian ...
Brooke M. Van Loh +11 more
wiley +1 more source
Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development
Frontiers in Endocrinology, 2018 KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs ...
Federica Fratangelo +3 more
doaj +1 more source
The effect of ghrelin on Kiss-1 and KissR gene transcription and insulin secretion in rat islets of Langerhans and CRI-D2 cell line [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Ghrelin is a peptide hormone that has been shown to have numerous central and peripheral effects. The central effects including GH secretion, food intake, and energy homeostasis are partly mediated by Kiss1- KissR signaling pathway. Ghrelin
Mandana Mahmoodzaeh Sagheb +2 more
doaj +1 more source
Aquaculture Reports, 2022 Previous studies have shown the regulation of follicle-stimulating hormone (Fshβ) and luteinizing hormone (Lhβ) during early ovarian differentiation and development from 30 to 160 days post-hatching (dph) in the red-spotted grouper.
Wengang Xu +3 more
doaj +1 more source
Kisspeptin and Clinical Disorders [PDF]
, 2013 The hypothalamic hormone GnRH has traditionally been viewed as a central driver of the hypothalamic-pituitary-gonadal axis. Pulsatile GnRH release is required for pulsatile gonadotropin secretion, which then modulates gonadal steroid feedback and brings about full fertility in the adult.
Letícia Gontijo, Silveira +2 more
openaire +2 more sources