Results 91 to 100 of about 2,088 (213)

Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.

, 2015
Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet, whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of their reproductive effects remains debatable.
Manfredi-Lozano, Maria, Schutz, Günther, Romero-Ruiz, Antonio, Heras, Violeta, Kirilov, Milen, Gaytan, Francisco, Leon, Silvia, Tena-Sempere, Manuel, Garcia-Galiano, David, Roa, Juan, Ruiz-Pino, Francisco, Vazquez, Maria J, Pinilla, Leonor, Barroso, Alexia   +13 more
core   +1 more source

Sustained induction of PMOS‐like phenotype in mice exposed to letrozole in drinking water

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS; formerly polycystic ovary syndrome) is the most common endocrinopathy affecting women of reproductive age, characterized by ovarian dysfunction and hyperandrogenism, with metabolic disturbances including insulin resistance and obesity also present for 50% of PMOS patients.
Kennedy A. Stevenson, Romy Kerbus, Greg M. Anderson, Caroline Decourt   +3 more
wiley   +1 more source

Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

eLife, 2020
The kisspeptin system is a central modulator of the hypothalamic-pituitary-gonadal axis in vertebrates. Its existence outside the vertebrate lineage remains largely unknown. Here, we report the identification and characterization of the kisspeptin system
Tianming Wang, Zheng Cao, Zhangfei Shen, Jingwen Yang, Xu Chen, Zhen Yang, Ke Xu, Xiaowei Xiang, Qiuhan Yu, Yimin Song, Weiwei Wang, Yanan Tian, Lina Sun, Libin Zhang, Su Guo, Naiming Zhou   +15 more
doaj   +1 more source

The Role and Mechanism of Incretins in Gynaecologic Diseases

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
This review outlines the mechanisms of incretins in polycystic ovary syndrome, endometriosis and gynaecological cancers, highlighting the translational potential of incretin‐based therapies for metabolic‐associated gynaecological disorders. ABSTRACT Background Obesity is a major global public health concern closely linked to the development and ...
Jiayu Yan, Minyue Cao, Yan Ding, Yiqin Zhang, Yihan Sun, Genyi Jiang, Yanli Zhang, Luyao Kang, Xue Zhou, Jing Luo, Bilan Li   +10 more
wiley   +1 more source

Menopausal hormone therapy and comprehensive postmenopausal care in gynecologic cancer survivors: A position paper from the FIGO Committee on Women at Menopausal Age

International Journal of Gynecology &Obstetrics, Volume 174, Issue 3, Page 1151-1171, September 2026.
Abstract Recent advances in cancer screening, diagnosis, and treatment have greatly improved survival rates among women with gynecologic cancers. More survivors now live long enough to experience treatment‐related menopause. Vasomotor symptoms, genitourinary syndrome of menopause, sexual dysfunction, sleep issues, and long‐term risks from estrogen ...
Agnaldo Lopes da Silva‐Filho, Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea R. Genazzani, Diana Ramos, Elizabete Argale, Enrique Herrera, Martha Hickey   +8 more
wiley   +1 more source

Fertility outcomes and ovarian function recovery after anti‐NMDAR encephalitis: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1823-1832, September 2026.
Acute hypothalamic–pituitary–ovarian axis suppression is common in anti‐NMDAR encephalitis, yet ovarian function and fertility recover favorably even in teratoma‐associated cases, supporting reassuring long‐term reproductive prognoses. Abstract Introduction Anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) encephalitis predominantly affects women of ...
Jia Wang, Jie Ding, Han Cai, YingXiang Wang, HaoTian Wu   +4 more
wiley   +1 more source

Abstract 4841: Suppression of metastasis by KP54 and non-KP54 kisspeptins

, 2017
KISS1 is a secreted neuropeptide which can act as a metastasis suppressor protein. Expression of KISS1 inhibits metastatic colonization at secondary sites, rendering disseminated cells dormant.
Danny R. Welch, Keke M. Pounds, Andrew P. Trembath, Kelsey Rebecca Hampton   +3 more
core   +1 more source

Development and aging of the Kisspeptin-GPR54 system in the mammalian brain: what are the impacts on female reproductive function?

Frontiers in Endocrinology, 2013
The prominent role of the G protein coupled receptor GPR54 and its peptide ligand kisspeptin in the progression of puberty has been extensively documented in many mammalian species including humans. Kisspeptins are very potent GnRH secretagogues produced
Isabelle eFranceschini, Elodie eDesroziers   +1 more
doaj   +1 more source

Thyroid hormone and seasonal rhythmicity

Frontiers in Endocrinology, 2014
Living organisms show seasonality in a wide array of functions such as reproduction, fattening, hibernation and migration. At temperate latitudes, changes in photoperiod maintain the alignment of annual rhythms with predictable changes in the environment.
Hugues eDardente, Hugues eDardente, Hugues eDardente, Hugues eDardente, David G Hazlerigg, Francis JP Ebling   +5 more
doaj   +1 more source

Temporal dynamics and diagnostic utility of kisspeptin and neudesin across the menstrual cycle in polycystic ovary syndrome

Middle East Fertility Society Journal
Background Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that is characterized by neuroendocrine dysfunction. While gonadotropin dysregulation is well established, the roles of neuropeptides, such as kisspeptin and neudesin, remain ...
Ammar Jabbar Taama, Haider Abd Jabbar Alammar   +1 more
doaj   +1 more source