Results 91 to 100 of about 1,992 (211)

Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo.

PLoS ONE, 2017
Kisspeptins regulate the mammalian reproductive axis by stimulating release of gonadotrophin releasing hormone (GnRH). Different length kisspeptins (KP) are found of 54, 14, 13 or 10 amino-acids which share a common C-terminal 10-amino acid sequence.
Xavier d'Anglemont de Tassigny, Channa N Jayasena, Kevin G Murphy, Waljit S Dhillo, William H Colledge   +4 more
doaj   +1 more source

Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models

Experimental Physiology, Volume 111, Issue 8, Page 3800-3817, 1 August 2026.
Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar, Seval Ulku Orhan, Cigdem Tekin, Asli Taslidere, Mete Ozcan, Suat Tekin   +5 more
wiley   +1 more source

Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

eLife, 2020
The kisspeptin system is a central modulator of the hypothalamic-pituitary-gonadal axis in vertebrates. Its existence outside the vertebrate lineage remains largely unknown. Here, we report the identification and characterization of the kisspeptin system
Tianming Wang, Zheng Cao, Zhangfei Shen, Jingwen Yang, Xu Chen, Zhen Yang, Ke Xu, Xiaowei Xiang, Qiuhan Yu, Yimin Song, Weiwei Wang, Yanan Tian, Lina Sun, Libin Zhang, Su Guo, Naiming Zhou   +15 more
doaj   +1 more source

Protein and Peptide Inhibitors of Mineralization: A Systematic Review of In Vitro Studies

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
In vitro evidence from crystallization assays demonstrates that peptides inhibit mineral nucleation and crystal growth through sequence‐dependent interactions (acidic residues and phosphorylation) with mineral surfaces. In cell cultures, these molecules reduce calcium deposition and ALP activity and modulate the expression of biomineralization‐related ...
Alberto Mimila‐Cortes, Lucia Méndez‐Sánchez, Luis Fernando Ramírez‐González, Lia Hoz‐Rodríguez, Maricela Santana‐Vázquez, Karen Ivette Castro‐López, Higinio Arzate, Gonzalo Montoya‐Ayala   +7 more
wiley   +1 more source

Placental Kisspeptins Differentially Modulate Vital Parameters of Estrogen Receptor-Positive and -Negative Breast Cancer Cells. [PDF]

, 2016
Kisspeptins (KPs) are major regulators of trophoblast and cancer invasion. Thus far, limited and conflicting data are available on KP-mediated modulation of breast cancer (BC) metastasis; mostly based on synthetic KP-10, the most active fragment of KP ...
Arefi, S., Amir-Hassan Zarnani, Ahmad-Reza Mahmoudi, Ebrahim Mirzadegan, Soheila Arefi, Jamileh Ghasemi, Simin Rezania, Mahmoudi, A.-R., Ghasemi, J., Mirzadegan, E., Kazemnejad, S., Zahra Rasoulzadeh, Roya Ghods, Nassim Ghaffari-Tabrizi-Wizsy, Rezania, S., Zarnani, A.-H., Tohid Kazemi, Kazemi, T., Ghods, R., Sedigheh Vafaei, Rasoulzadeh, Z., Ghaffari-Tabrizi-Wizsy, N., Vafaei, S., Somaieh Kazemnejad   +23 more
core   +2 more sources

Pubertal development and hypothalamic–pituitary–gonadal axis are altered in male mice lacking Mecp2

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Ana Martín‐Sánchez, Daniela Jiménez‐Díaz, Rafael Esteve‐Pérez, Alexandru Vasile‐Tudorache, Jordan E. Read, Sasha R. Howard, Carmen Agustín‐Pavón   +6 more
wiley   +1 more source

Design and synthesis of fluorescent probes for GPR54. [PDF]

, 2014
Kisspeptins are neuropeptides that induce the secretion of gonadotropin-releasing hormone via the activation of the cognate receptor, G-protein coupled receptor 54 (GPR54).
Uenoyama, Yoshihisa, Kaneda, Masato, Fujii, Nobutaka, Ohno, Hiroaki, Misu, Ryosuke, Maeda, Kei-ichiro, Ieda, Nahoko, Oishi, Shinya, Hirasawa, Akira, Tsukamura, Hiroko   +9 more
core   +1 more source

Decoding Aquaculture's Future: A Review of Molecular Docking and Simulation in Enhancing Growth and Disease Resistance

Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT Aquaculture has overtaken capture fisheries as the main source of aquatic animal protein, marking a critical step in global food security. Yet, rapid intensification faces major challenges, including disease outbreaks, environmental degradation, and dependence on wild‐caught fish for feed.
Suvadip Ghara, Iyyappan Somasundaram, Mohd Ashraf Rather, Mukilan Aakash, Mary Divya B, Irfan Ahmad Bhat, Irfan Ahmad Khan, Vlastimil Stejskal, Elayaraja Sivaramasamy   +8 more
wiley   +1 more source

First evidence for a direct inhibitory effect of kisspeptins on LH expression in the eel, Anguilla anguilla

, 2011
International audienceThe kisspeptin system has emerged as one of the main puberty gatekeepers among vertebrates. The European eel (Anguilla anguilla) is a remarkable model due to its phylogenetical position at the basis of teleosts, and its unique life ...
H. Vaudry, Rousseau, Karine, Vaudry, Hubert, A.-G. Lafont, Dufour, Sylvie, K. Rousseau, Lafont, Anne-Gaëlle, Pasquier, Jérémy, Leprince, Jérôme, S. Dufour, J. Pasquier, J. Leprince   +11 more
core   +1 more source

Development and aging of the Kisspeptin-GPR54 system in the mammalian brain: what are the impacts on female reproductive function?

Frontiers in Endocrinology, 2013
The prominent role of the G protein coupled receptor GPR54 and its peptide ligand kisspeptin in the progression of puberty has been extensively documented in many mammalian species including humans. Kisspeptins are very potent GnRH secretagogues produced
Isabelle eFranceschini, Elodie eDesroziers   +1 more
doaj   +1 more source