Results 111 to 120 of about 1,992 (211)
Kisspeptin and Endometriosis—Is There a Link?
Journal of Clinical MedicineThis article presents a narrative review that explores the potential link between kisspeptin—a key regulator of the hypothalamic-pituitary-gonadal axis—and the pathogenesis of endometriosis. Kisspeptin plays a significant role in regulating reproductive functions by modulating the release of gonadotropin-releasing hormone (GnRH), which in turn ...
Blazej Meczekalski +5 more
openaire +2 more sources
A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10
American Journal of Physiology-Endocrinology and Metabolism, 2010 The kisspeptins are neuropeptides that stimulate the hypothalamo-pituitary-gonadal (HPG) axis. The smallest endogenous kisspeptin, kisspeptin-10 (KP-10), binds to the receptor KISS1R with a similar affinity to the full-length peptide, kisspeptin-54 (KP-54), but is less effective in vivo, possibly because of increased enzymatic breakdown or clearance ...
Curtis, Annette E. +7 more
openaire +3 more sources
Functional studies of kisspeptin analogues and the human kisspeptin receptor
, 2023 Kisspeptins and their cognate receptor, the kisspeptin receptor, play pivotal roles in the regulation of the development of puberty and cancer metastasis. However, the signalling pathways activated by kisspeptins and the kisspeptin receptor remain largely to be demonstrated.
openaire +1 more source
Nodavirus infection alters the kisspeptins pathway in European sea bass brain
, 2015 In vertebrates, the kisspeptins pathway in the brain is an essential upstream regulatory element of the hypothalamus - pituitary - gonad (HPG) axis, which regulates reproduction. In European sea bass it has been described two forms of kisspeptin genes,
Arizcun-Arizcun, M. (Marta) +11 more
core
A G-rich sequence within the 3'UTR of KiSS1 forms G-quadruplex [PDF]
, 2010 L’obiettivo dello studio è stato quello di dimostrare che la regione ricca in guanine del 3’UTR del gene KiSS1 forma effettivamente strutture secondarie G-quadruplex e di capire se i polimorfismi trovati nei pazienti affetti da pubertà precoce ...
Bonafè, Giulia
core
, 2012 Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as ligands of the G protein-coupled receptor 54 (GPR54; also termed Kiss1R) with ability to suppress tumor metastasis.
Tena-Sempere, Manuel +9 more
core +1 more source
Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications [PDF]
, 2019 BACKGROUND: Ectopic pregnancy is a life-threatening condition for which novel screening tools that would enable early accurate diagnosis would improve clinical outcomes.
A., Romero-Ruiz +16 more
core +1 more source
Kisspeptins and Their Receptor
, 2009 Juan M. Castellano, Manuel Tena-Sempere
openaire +2 more sources
Kisspeptin and its Effect on Mammalian Spermatogensis
, 2019 Background: Kisspeptin and its receptor, GPR54, are regarded as key regulators of and catalysts for male puberty onset, and also fundamental gatekeepers of spermatogenesis in mammals.
Yan Liu +3 more
core +1 more source