Results 81 to 90 of about 2,088 (213)
Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.Abstract The hypothalamic–pituitary–gonadal (HPG) axis coordinates reproductive function and incorporates gonadal sex steroid feedback to regulate gonadotropin secretion in a homeostatic manner. In females, ovarian estrogens and progestins act as the primary negative feedback signals to suppress luteinizing hormone (LH) release, whereas in males ...
Lillian Rose, Alexander S. Kauffman
wiley +1 more source
Frontiers in Endocrinology, 2016 Reproduction is essential for perpetuation of the species and, hence, is controlled by a sophisticated network of regulatory factors of central and peripheral origin that integrate at the hypothalamic-pituitary gonadal (HPG) axis.
Silvia eLeon, Manuel eTena-Sempere
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Pattern of gonadotropin secretion along the estrous cycle of C57BL/6 female mice
Physiological Reports, 2022 The pattern of gonadotropin secretion along the estrous cycle was elegantly described in rats. Less information exists about the pattern of gonadotropin secretion in gonad‐intact mice, particularly regarding the follicle‐stimulating hormone (FSH).
Daniela O. Gusmao +7 more
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Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.Ethanolamine plasmalogens increased LH pulse frequency. GPR61 was expressed in GnRH neurons and gonadotrophs, suggesting a role in neuroendocrine regulation. Ethanolamine plasmalogens (EPls), but not choline plasmalogens (CPls), may act via GPR61 expressed in GnRH neurons in the preoptic area and in anterior pituitary gonadotrophs.
Hiroya Kadokawa +4 more
wiley +1 more source
GPR54 and kisspeptin in reproduction [PDF]
Human Reproduction Update, 2006 Abstract Kisspeptins, the peptide products of the KiSS-1 gene, were identified in 2001 as natural ligands of the previously orphan G protein-coupled receptor, GPR54. They include, among others, metastin and kisspeptin-10. The known biological functions of kisspeptins were initially restricted to their ability to suppress tumour ...
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Frontiers in Endocrinology, 2018 Kisspeptin, a novel neuropeptide product of the Kiss1 gene, activates the G protein-coupled membrane receptor G protein-coupled receptor 54 (now termed Kiss1r).
Hirofumi Ohga +2 more
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Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.Abstract To describe clinical presentation and genetic findings in a cohort of infants with congenital hypogonadotropic hypogonadism (CHH) diagnosed before 2 years of age. From a large cohort of patients who underwent next‐generation sequencing (NGS) for CHH between 2019 and 2025, we identified all patients tested at ≤2 years of age.
Karine Aouchiche +16 more
wiley +1 more source
Dynamic Kisspeptin Receptor Trafficking Modulates Kisspeptin-Mediated Calcium Signaling [PDF]
Molecular Endocrinology, 2014 Abstract Kisspeptin receptor (KISS1R) signaling plays a critical role in the regulation of reproduction. We investigated the role of kisspeptin-stimulated KISS1R internalization, recycling, and degradation in the modulation of KISS1R signaling.
Le, Min +7 more
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, 2012 Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as ligands of the G protein-coupled receptor 54 (GPR54; also termed Kiss1R) with ability to suppress tumor metastasis.
Tena-Sempere, Manuel +9 more
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Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo.
PLoS ONE, 2017 Kisspeptins regulate the mammalian reproductive axis by stimulating release of gonadotrophin releasing hormone (GnRH). Different length kisspeptins (KP) are found of 54, 14, 13 or 10 amino-acids which share a common C-terminal 10-amino acid sequence.
Xavier d'Anglemont de Tassigny +4 more
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