Results 81 to 90 of about 2,975 (220)

A concept for a new approach to combined oral contraception from adolescence to perimenopause: Continuous use of the oral GnRH antagonist Relugolix and the fetal estrogen Estetrol

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 4, Page 568-574, April 2026.
It is expected that the relugolix estetrol combination RE4W will enable women to control their fertility and prevent menstrual cycle related problems, while offering a smooth transition through perimenopause into the postmenopause and decrease the risk of breast cancer.
Herjan J. T. Coelingh Bennink, Karolina Afors, Luis Bahamondes, Alessandra Graziottin, Deborah Bateson, Teresa Bombas, Yutaki Osuga, Santiago Palacios, Carolyn L. Westhoff, Kristina Gemzell‐Danielsson   +9 more
wiley   +1 more source

Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Cleisla Souza Oliveira, Maria Clara Pascoal Santos Alvarez, Natália Panhoca Rodrigues, Jorge Lopez‐Tello, Amanda N. Sferruzzi‐Perri, Rogéria Serakides, Juneo Freitas Silva   +9 more
wiley   +1 more source

Control neuroendocrí de l'inici de la maduresa sexual en els vertebrats mitjançant la kisspeptina i el seu receptor, amb especial èmfasi pel que fa a la situació en els peixos teleostis [PDF]

, 2009
El recent descobriment de la kisspeptina (producte del gen KISS1), conjuntament amb el seu receptor (producte del gen KISS1R), i de la seva relació amb el control de l'inici de la maduresa sexual en tots els vertebrats, ha estat descrit com una de les ...
Mechaly, Alejandro, Piferrer i Circuns, Francesc, Viñas, Jordi   +2 more
core  

GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract The arcuate nucleus kisspeptin (ARNKISS) neurons intermittently synchronize their activity to operate as the GnRH pulse generator and drive pulsatile reproductive hormone secretion in mammals. Although ARNKISS neurons are known to receive various GABAergic inputs, the effects of GABAA and GABAB receptor modulation on their ability to ...
Toby Eddleston, Paul G. Morris, Allan E. Herbison   +2 more
wiley   +1 more source

Novel galanin receptors in teleost fish: identification, expression and regulation by sex steroids [PDF]

, 2014
In fish, the onset of puberty, the transition from juvenile to sexually reproductive adult animals, is triggered by the activation of pituitary gonadotrophin secretion and its timing is influenced by external and internal factors that include the growth/
Canario, Adelino V. M., Carrillo, Manuel, Guerreiro, P. M., Martins, Rute S. T., Pinto, Patricia IS, Zanuy, Silvia   +5 more
core   +1 more source

GPR54 and kisspeptin in reproduction [PDF]

Human Reproduction Update, 2006
Kisspeptins, the peptide products of the KiSS-1 gene, were identified in 2001 as natural ligands of the previously orphan G protein-coupled receptor, GPR54. They include, among others, metastin and kisspeptin-10. The known biological functions of kisspeptins were initially restricted to their ability to suppress tumour metastasis, hence the name of ...
openaire   +2 more sources

Arcuate nucleus‐specific progesterone receptor knockdown in female mice is sufficient to induce PCOS‐like hyperactivity in the reproductive axis

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract Mammalian reproductive function is dependent upon gonadal steroid hormone feedback within the hypothalamic–pituitary–gonadal (HPG) axis. In polycystic ovary syndrome (PCOS), impaired progesterone (P4) negative feedback leads to hyperactive pulsatile secretion of luteinising hormone (LH) and impaired reproductive function.
Kelly A. Glendining, Melanie Prescott, Kyoko Potapov, Elodie Kip, Rebecca E. Campbell   +4 more
wiley   +1 more source

Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies using Pharmacological Tools and Genetically Modified Mouse Models

Frontiers in Endocrinology, 2016
Reproduction is essential for perpetuation of the species and, hence, is controlled by a sophisticated network of regulatory factors of central and peripheral origin that integrate at the hypothalamic-pituitary gonadal (HPG) axis.
Silvia eLeon, Manuel eTena-Sempere
doaj   +1 more source

Haploinsufficiency of Dmxl2, Encoding a Synaptic Protein, Causes Infertility Associated with a Loss of GnRH Neurons in Mouse [PDF]

, 2014
International audienceCharacterization of the genetic defects causing gonadotropic deficiency has made a major contribution to elucidation of the fundamental role of Kisspeptins and Neurokinin B in puberty onset and reproduction.
Carel, Jean-Claude, Charles, Perrine, Chevenne, Didier, Csaba, Zsolt, de Roux, Nicolas, Dupont, Joelle, Genin, Emmanuelle, Huijbregts, Lukas, Jacquier, Sandrine, Leka, Sofia, Léger, Juliane, Meyer, Vincent, Tata, Brooke   +12 more
core   +7 more sources

The Roles of Kisspeptin System in the Reproductive Physiology of Fish With Special Reference to Chub Mackerel Studies as Main Axis

Frontiers in Endocrinology, 2018
Kisspeptin, a novel neuropeptide product of the Kiss1 gene, activates the G protein-coupled membrane receptor G protein-coupled receptor 54 (now termed Kiss1r).
Hirofumi Ohga, Sethu Selvaraj, Michiya Matsuyama   +2 more
doaj   +1 more source