Results 81 to 90 of about 1,992 (211)

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Abstract 4841: Suppression of metastasis by KP54 and non-KP54 kisspeptins

, 2017
KISS1 is a secreted neuropeptide which can act as a metastasis suppressor protein. Expression of KISS1 inhibits metastatic colonization at secondary sites, rendering disseminated cells dormant.
Danny R. Welch, Keke M. Pounds, Andrew P. Trembath, Kelsey Rebecca Hampton   +3 more
core   +1 more source

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li, Jingwei Mao, Yiwen Deng, Xiaobo Ge, Limin Nie, Qun Wang, Ruiqing Wang, Jiarun Zhang, Tianli Lyu, Luopeng Zhao, Lu Liu, Bin Li   +11 more
wiley   +1 more source

Dynamic Kisspeptin Receptor Trafficking Modulates Kisspeptin-Mediated Calcium Signaling [PDF]

Molecular Endocrinology, 2014
Abstract Kisspeptin receptor (KISS1R) signaling plays a critical role in the regulation of reproduction. We investigated the role of kisspeptin-stimulated KISS1R internalization, recycling, and degradation in the modulation of KISS1R signaling.
Le, Min, Kathleen, Soltis, Ana Claudia S, Reis, Shuyun, Xu, Wendy, Kuohung, Manisha, Jain, Rona S, Carroll, Ursula B, Kaiser   +7 more
openaire   +2 more sources

Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.

, 2015
Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet, whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of their reproductive effects remains debatable.
Manfredi-Lozano, Maria, Schutz, Günther, Romero-Ruiz, Antonio, Heras, Violeta, Kirilov, Milen, Gaytan, Francisco, Leon, Silvia, Tena-Sempere, Manuel, Garcia-Galiano, David, Roa, Juan, Ruiz-Pino, Francisco, Vazquez, Maria J, Pinilla, Leonor, Barroso, Alexia   +13 more
core   +1 more source

Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies using Pharmacological Tools and Genetically Modified Mouse Models

Frontiers in Endocrinology, 2016
Reproduction is essential for perpetuation of the species and, hence, is controlled by a sophisticated network of regulatory factors of central and peripheral origin that integrate at the hypothalamic-pituitary gonadal (HPG) axis.
Silvia eLeon, Manuel eTena-Sempere
doaj   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

The Roles of Kisspeptin System in the Reproductive Physiology of Fish With Special Reference to Chub Mackerel Studies as Main Axis

Frontiers in Endocrinology, 2018
Kisspeptin, a novel neuropeptide product of the Kiss1 gene, activates the G protein-coupled membrane receptor G protein-coupled receptor 54 (now termed Kiss1r).
Hirofumi Ohga, Sethu Selvaraj, Michiya Matsuyama   +2 more
doaj   +1 more source

Pattern of gonadotropin secretion along the estrous cycle of C57BL/6 female mice

Physiological Reports, 2022
The pattern of gonadotropin secretion along the estrous cycle was elegantly described in rats. Less information exists about the pattern of gonadotropin secretion in gonad‐intact mice, particularly regarding the follicle‐stimulating hormone (FSH).
Daniela O. Gusmao, Henrique R. Vieira, Naira S. Mansano, Mariana R. Tavares, Ligia M. M. deSousa, Frederick Wasinski, Renata Frazao, Jose Donato Jr   +7 more
doaj   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, Volume 28, Issue S4, Page 3-16, August 2026.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source