Hormonal regulation of female reproduction [PDF]
, 2012 Reproduction is an event that requires the coordination of peripheral organs with the nervous system to ensure that the internal and external environments are optimal for successful procreation of the species.
Bentley, G. E. +6 more
core +1 more source
Circadian regulation of reproduction: From gamete to offspring [PDF]
, 2013 P01326625; Grants: GNT0519315Few challenges are more critical to the survival of a species than reproduction. To ensure reproductive success, myriad aspects of physiology and behaviour need to be tightly orchestrated within the animal, as well as timed ...
Boden, M., Kennaway, D., Varcoe, T.
core +1 more source
Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep [PDF]
, 2016 We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary ...
Bellingham, M. +7 more
core +2 more sources
Pacemaking kisspeptin neurons [PDF]
Experimental Physiology, 2013 New findings What is the topic for this review?This review focuses on analysis of the electrophysiological properties of hypothalamic kisspeptin neurons. What advances does it highlight?Molecular and cellular electrophysiological analysis of kisspeptin neurons reveals that they express the critical pacemaker channels for generating burst‐firing ...
Martin J, Kelly +3 more
openaire +2 more sources
Kisspeptin: Beyond the Brain [PDF]
Endocrinology, 2015 The hypothalamic-based kisspeptin-signaling system is a major positive regulator of the neuroendocrine-reproductive axis in mammals. During the last decade, major advances have been made in understanding how this signaling system is regulated and how it can be manipulated clinically to achieve beneficial outcomes in treating sex steroid-dependent ...
Moshmi, Bhattacharya, Andy V, Babwah
openaire +2 more sources
Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice. [PDF]
, 2017 The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion. Kiss1-syntheizing neurons reside primarily in the hypothalamic anteroventral periventricular (AVPV/PeN) and arcuate (ARC) nuclei.
Chahal, Navi +6 more
core +1 more source
Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells [PDF]
, 2013 Reproduction is integrated by interaction of neural and hormonal signals converging on hypothalamic neurons for controlling gonadotropin-releasing hormone (GnRH).
Glidewell-Kenney, Christine +9 more
core +1 more source
Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype. [PDF]
, 2019 Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity ...
Kauffman, Alexander S +4 more
core +1 more source
Functional examination of novel kisspeptin phosphinic peptides [PDF]
, 2018 Kisspeptins acting on their cognate G protein-coupled receptor, kisspeptin receptor, play important roles in the suppression of cancer cell metastasis and regulation of the reproductive system, and therefore are important for therapeutic intervention ...
Fernig, David +6 more
core +4 more sources
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source