Results 21 to 30 of about 6,216 (180)
BMC Women's Health, 2023 Highlights 1. Kisspeptin expression is decreased in ovaries of PCOS rat 2. Kisspeptin promotes proliferation and inhibits apoptosis of granulosa cells 3. Kisspeptin alleviates oxidative stress of granulosa cells 4.
Pingping Sun +5 more
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Chronic kisspeptin delays puberty and reduces feed intake and body weight in female rats
Journal of Animal Reproduction and Biotechnology, 2021 Kisspeptin is a key player in the central control of reproductive axis. Central administration of kisspeptin has been shown to advance puberty in rats. Stimulation of hypothalamic GnRH pulse generating mechanism by kisspeptin has been proposed to be the ...
Sriravali Sathagopam +3 more
doaj +1 more source
Role of Kisspeptin-GPR54 system in regulation of reproductive functions in human and other mammals
Pakistan Journal of Pharmaceutical Sciences, 2021 Kisspeptin is a 54- amino acid peptide that acts as a ligand of a receptor called GPR54 which is basically a transmembrane receptor that spins seven times across the cell membrane and coupled with G-protein.
Ikram Ilahi, Taqweem Ul Haq
doaj +1 more source
Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders [PDF]
Endocrinology and Metabolism, 2015 Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Loss of kisspeptin signaling
Holly Clarke +2 more
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MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors [PDF]
Journal of Molecular Endocrinology, 2014 Following the discovery of kisspeptin (Kiss) and its receptor (GPR54 or KissR) in mammals, phylogenetic studies revealed up to three Kiss and four KissR paralogous genes in other vertebrates. The multiplicity of Kiss and KissR types in vertebrates probably originated from the two rounds of whole-genome duplication (1R and 2R) that ...
Pasquier, Jérémy +5 more
openaire +4 more sources
Open Veterinary Journal, 2023 Background: Kisspeptin is a neuropeptide that has an important role in the female reproductive cycle which is indicated by its role in regulating the hypothalamic-pituitary-gonadal axis (HPG axis).
Achmad Rheza +2 more
doaj +1 more source
The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin
International Journal of Endocrinology, 2020 Background. Kisspeptin is a neuropeptide that upregulates gonadotropin-releasing hormone (GnRH) secretion. It is an essential element for the luteinizing hormone (LH) surge and ovulation.
Razaw O. Ibrahim +2 more
doaj +1 more source
The Effects of 5-Hydroxytryptamine and Interaction With Kisspeptin in Controlling Ghrelin and Adiponectin Secretion [PDF]
International Journal of Basic Science in Medicine, 2022 Introduction: 5-Hydroxytryptamine (5HT) and kisspeptin are satiety factors, and ghrelin and adiponectin are orexigenic peptides. In this study, the mediating role of 5HT in the effects of GPR54 receptor blocking on ghrelin and adiponectin secretion was ...
Maryam Kamvar +4 more
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Current Perspectives on Kisspeptins Role in Behaviour
Frontiers in Endocrinology, 2022 The neuropeptide kisspeptin is now well-established as the master regulator of the mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate receptor are also extensively distributed in extra-hypothalamic brain regions.
Edouard G. Mills +6 more
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Functional examination of novel kisspeptin phosphinic peptides. [PDF]
PLoS ONE, 2018 Kisspeptins acting on their cognate G protein-coupled receptor, kisspeptin receptor, play important roles in the suppression of cancer cell metastasis and regulation of the reproductive system, and therefore are important for therapeutic intervention ...
Xiaoyang Zhang +6 more
doaj +1 more source