Kisspeptin and fertility [PDF]
Journal of Endocrinology, 2010 The kisspeptins are a family of peptide hormones, which in recent years have been shown to play a critical role in the regulation of the hypothalamic-pituitary-gonadal axis, thus in turn influencing fertility and reproduction. This review examines the physiological role of kisspeptin and the kisspeptin receptor in the control of gonadotrophin and ...
Saira, Hameed +2 more
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MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors [PDF]
Journal of Molecular Endocrinology, 2014 Following the discovery of kisspeptin (Kiss) and its receptor (GPR54 or KissR) in mammals, phylogenetic studies revealed up to three Kiss and four KissR paralogous genes in other vertebrates. The multiplicity of Kiss and KissR types in vertebrates probably originated from the two rounds of whole-genome duplication (1R and 2R) that ...
Pasquier, Jérémy +5 more
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Quantification of Rat Kisspeptin Using a Novel Radioimmunoassay [PDF]
, 2014 Kisspeptin is a hypothalamic peptide hormone that plays a pivotal role in pubertal onset and reproductive function. Previous studies have examined hypothalamic kisspeptin mRNA expression, either through in situ hybridisation or real-time RT-PCR, as a ...
Stephen R. Bloom +32 more
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Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]
, 2012 Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques +13 more
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Altered placental expression of kisspeptin and its receptor in pre-eclampsia [PDF]
, 2012 Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy.
Williams, Paula Juliet +3 more
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Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]
, 2012 Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László +11 more
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The role of kisspeptin in reproduction [PDF]
, 2014 Kisspeptin is a recently identified hypothalamic neuropeptide hormone which is a critical regulator of mammalian reproductive physiology. In addition, kisspeptin administration stimulates gonadotrophin release in all species tested.
Comninos, Alexander
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Kisspeptin Signaling in the Brain [PDF]
Endocrine Reviews, 2009 Abstract Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key players in the regulation of reproduction. Mutations in humans or genetically targeted deletions in mice of either Kiss1 or Kiss1r cause profound hypogonadotropic hypogonadism.
Amy E, Oakley +2 more
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Kisspeptin: A Potential Therapathic Target in Patients with Unexplained Infertility?
, 2021 Kisspeptin has recently emerged as a key regulator of the reproductive axis in women. Kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Here, we aimed to investigate serum kisspeptin
atakul, N (via Mendeley Data) +1 more
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Interactions of GPR54 and GPR147 receptors with RF-amide ligands [PDF]
, 2014 Includes bibliographical references.G protein-coupled receptors play a key role in cellular signaling by transducing extracellular signals via G proteins to elicit intracellular responses.
Hendrikse, Megan
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