Results 41 to 50 of about 13,445 (168)

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Factors Associated With Non‐Vasomotor Menopause Symptoms Experienced by 7285 Women: A UK‐Wide National Survey

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate the factors associated with non‐vasomotor menopause symptoms among women in the UK, focusing on the perceived importance of specific symptoms and their association with demographic and treatment‐related factors. Design A cross‐sectional online survey.
Rhianna Davies, Ashwin Goyal, Zachary Nash, Sarah Hillman, Melanie Davies, Nick Panay, Jane Daniels, Tim Hillard, Bonnie Grant, Paula Briggs, Lynne Robinson, Haitham Hamoda, Channa N. Jayasena   +12 more
wiley   +1 more source

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation [PDF]

Human Reproduction Update, 2018
Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include ...
Kai-Lun Hu, Hsun-Ming Chang, Hong-Cui Zhao, Yang Yu, Rong Li, Jie Qiao   +5 more
openaire   +2 more sources

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]

, 2013
Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
core   +1 more source

Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause

Experimental Physiology, EarlyView.
Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller, M. Erin Moir, Brandon G. Fico   +2 more
wiley   +1 more source

Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor [PDF]

Neuroendocrinology, 2012
Kisspeptin signaling in the hypothalamus appears critical for the onset of puberty and driving the reproductive axis. In sheep, reproduction is seasonal, being activated by short days and inhibited by long days. During the non-breeding (anestrous) season, gonadotropin-releasing hormone (GnRH) and gonadotropin secretion is reduced, as is the expression ...
Qun, Li, Alexandra, Roa, Iain J, Clarke, Jeremy T, Smith   +3 more
openaire   +2 more sources

The "ram effect": new insights into neural modulation of the gonadotropic axis by male odors and socio-sexual interactions [PDF]

, 2015
Reproduction in mammals is controlled by the hypothalamo-pituitary-gonadal (HPG) axis under the influence of external and internal factors such as photoperiod, stress, nutrition, and social interactions.
Abbott, Alim, Bakker, Baldwin, Baum, Beltramino, Ben Saïd, Birch, Blache, Boehm, Brennan, Brennan, Buck, Budry, Cahill, Caraty, Caraty, Chand, Chanvallon, Chanvallon, Chanvallon, Chanvallon, Chemineau, Clarke, Clarkson, Claude Fabre-Nys, Cohen-Tannoudji, Cohen-Tannoudji, Cohen-Tannoudji, De Bond, Dobson, Dorries, Dyrmundsson, Eley, Fabre-Nys, Fabre-Nys, Fabre-Nys, Fabre-Nys, Fabre-Nys, Fabre-Nys, Ferin, Fisher, Follett, Franceschini, Fulkerson, Gelez, Gelez, Gelez, Gelez, Ghenim, Gitler, Goldman, Goodman, Goodman, Goodman, Goodman, Goodman, Goodman, Goodman, Hamada, Hauger, Hawken, Hawken, Hawken, Herbison, Herbison, Herbison, Hodson, Hoffman, Hudson, Ichimaru, Jansen, Jiang, Johnson, Jorre de St. Jorre, Karsch, Karsch, Karsch, Kaynard, Keith M. Kendrick, Kelliher, Kendrick, Kevetter, Knight, Knight, Knobil, Kumar, Land, Lee, Lehman, Lindsay, Lindsay, Lévy, Maeda, Malpaux, Martin, Martin, Mauléon, Merkley, Messager, Mikkelsen, Moenter, Mori, Mormede, Murata, Murphy, Murtagh, Ohara, Ohkura, Oldham, Oldham, Oldham, Over, Pearce, Perkins, Pinilla, Poindron, Rex J. Scaramuzzi, Rivier, Roa, Sanchez-Andrade, Sara, Scaramuzzi, Shea, Shipka, Signoret, Signoret, Skinner, Swaney, Swann, Szawka, Thimonier, Tillet, Tillet, Tomaszewska-Zaremba, Tong, Tournadre, Treves, Tsutsumi, Uenoyama, Underwood, Ungerfeld, Ungerfeld, Vandenbergh, Walkden-Brown, Watson, Wersinger, Whitten, Yang, Yang, Yang, Yoon   +151 more
core   +4 more sources

Protein and Peptide Inhibitors of Mineralization: A Systematic Review of In Vitro Studies

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
In vitro evidence from crystallization assays demonstrates that peptides inhibit mineral nucleation and crystal growth through sequence‐dependent interactions (acidic residues and phosphorylation) with mineral surfaces. In cell cultures, these molecules reduce calcium deposition and ALP activity and modulate the expression of biomineralization‐related ...
Alberto Mimila‐Cortes, Lucia Méndez‐Sánchez, Luis Fernando Ramírez‐González, Lia Hoz‐Rodríguez, Maricela Santana‐Vázquez, Karen Ivette Castro‐López, Higinio Arzate, Gonzalo Montoya‐Ayala   +7 more
wiley   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Kisspeptin and Puberty in Mammals [PDF]

, 2013
Since the discovery of the G-protein coupled receptor 54 (kisspeptin receptor) and its ligand, kisspeptin, our understanding of the neurobiological mechanisms that govern the pituitary-gonadal axis has evolved dramatically. In this chapter, we have reviewed progress regarding the relationship between kisspeptin and puberty, and have proposed a novel ...
Ei, Terasawa, Kathryn A, Guerriero, Tony M, Plant   +2 more
openaire   +2 more sources