Results 41 to 50 of about 9,905 (169)

Arcuate kisspeptin neurons display two types of calcium events: Regulation by sex, gonads, and senktide

Journal of Neuroendocrinology, Volume 38, Issue 11, November 2026.
Abstract The pattern of gonadotropin‐releasing hormone (GnRH) release controls reproduction in vertebrates and is regulated by feedback from the gonads. Evidence is accumulating that steroid‐sensitive hypothalamic arcuate kisspeptin–neurokinin B–dynorphin (KNDy) neurons drive GnRH pulses.
R. Anthony DeFazio, Christian R. Burgess, Laura L. Burger, Amanda G. Gibson, Suzanne M. Moenter   +4 more
wiley   +1 more source

Kisspeptin and Clinical Disorders [PDF]

, 2013
The hypothalamic hormone GnRH has traditionally been viewed as a central driver of the hypothalamic-pituitary-gonadal axis. Pulsatile GnRH release is required for pulsatile gonadotropin secretion, which then modulates gonadal steroid feedback and brings about full fertility in the adult.
Letícia Gontijo, Silveira, Ana Claudia, Latronico, Stephanie Beth, Seminara   +2 more
openaire   +2 more sources

Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor [PDF]

Neuroendocrinology, 2012
Kisspeptin signaling in the hypothalamus appears critical for the onset of puberty and driving the reproductive axis. In sheep, reproduction is seasonal, being activated by short days and inhibited by long days. During the non-breeding (anestrous) season, gonadotropin-releasing hormone (GnRH) and gonadotropin secretion is reduced, as is the expression ...
Qun, Li, Alexandra, Roa, Iain J, Clarke, Jeremy T, Smith   +3 more
openaire   +2 more sources

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Functional characterisation and translational applications of kisspeptin-10 [PDF]

, 2012
BACKGROUND: Kisspeptins, recently discovered hypothalamic neuropeptides encoded by the KISS1 gene, are essential for normal pubertal development and are modulated by diverse endocrine, metabolic and environmental signals.
George, Jyothis Thomas
core  

Hypothalamic kisspeptin and kisspeptin receptors: Species variation in reproduction and reproductive behaviours

Frontiers in Neuroendocrinology, 2022
Kisspeptin, encoded by the KISS1 gene, was first discovered as a potential metastasis suppressor gene. The prepro-kisspeptin precursor is cleaved into shorter mature bioactive peptides of varying sizes that bind to the G protein-coupled receptor GPR54 (=KISS1R).
Mageswary Sivalingam, Ishwar S. Parhar
openaire   +2 more sources

Same Fat, Different Consequences? The Association Between Fat Distribution and Vasomotor Menopausal Symptoms Varies by Menopausal Status

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Body fat distribution was associated with vasomotor symptoms in a menopausal stage‐specific manner. Greater trunk and abdominal adiposity were linked to more frequent and bothersome symptoms during perimenopause, whereas distinct abdominal adiposity measures showed contrasting associations with symptom burden after menopause.
Katarzyna Górecka, Monika Krzyżanowska
wiley   +1 more source

Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer

, 2010
Kisspeptin, the product of the KiSS-1 gene, inhibits metastasis and stimulates the hypothalamo-pituitary-gonadal axis. Kisspeptin is therefore a putative target in the treatment of hormone-sensitive malignancies. Prostatic carcinoma remains a significant
Curtis, Annette E., Young, Anna-Mary, Murphy, Kevin G., Ramachandran, Radha, Chaudhri, Owais B., Ghatei, Mohammed A., Nijher, Gurjinder M. K., Bloom, Stephen R., Bewick, Gavin; id_orcid, Waxman, Jonathan, Dhillo, Waljt S.   +10 more
core   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 26-47, October 2026.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Kisspeptin Modulation of Reproductive Function

, 2022
Kisspeptin is a peptide expressed mainly in the infundibular nucleus of the hypothalamus. Kisspeptin plays a crucial role in the regulation of reproductive functions.
Blazej Meczekalski, Anna Szeliga
core   +1 more source