Results 51 to 60 of about 13,445 (168)
The Role of Kisspeptin in Sexual Behavior [PDF]
Seminars in Reproductive Medicine, 2019 AbstractSexual behavior is essential for the perpetuation of a species. In female rodents, mate preference and lordosis behavior depend heavily on the integration of olfactory cues into the neuroendocrine brain, yet its underlying neural circuits are not well understood.
Hellier, Vincent +2 more
openaire +4 more sources
Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice [PDF]
, 2018 Restraint stress is a psychosocial stressor that suppresses reproductive status, including LH pulsatile secretion, but the neuroendocrine mechanisms underlying this inhibition remains unclear.
Hughes, Jessica K +4 more
core +1 more source
Frontiers in Neuroendocrinology, 2022 Kisspeptin, encoded by the KISS1 gene, was first discovered as a potential metastasis suppressor gene. The prepro-kisspeptin precursor is cleaved into shorter mature bioactive peptides of varying sizes that bind to the G protein-coupled receptor GPR54 (=KISS1R).
Mageswary Sivalingam, Ishwar S. Parhar
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Kisspeptin and Clinical Disorders [PDF]
, 2013 The hypothalamic hormone GnRH has traditionally been viewed as a central driver of the hypothalamic-pituitary-gonadal axis. Pulsatile GnRH release is required for pulsatile gonadotropin secretion, which then modulates gonadal steroid feedback and brings about full fertility in the adult.
Letícia Gontijo, Silveira +2 more
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GPR54 and kisspeptin in reproduction [PDF]
Human Reproduction Update, 2006 Kisspeptins, the peptide products of the KiSS-1 gene, were identified in 2001 as natural ligands of the previously orphan G protein-coupled receptor, GPR54. They include, among others, metastin and kisspeptin-10. The known biological functions of kisspeptins were initially restricted to their ability to suppress tumour metastasis, hence the name of ...
openaire +2 more sources
Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors [PDF]
, 2012 The neuropeptides gonadotropin-releasing hormone (GnRH) and kisspeptin (KiSS), and their receptors gonadotropin-releasing hormone receptor (GnRHR) and kisspeptin receptor (KiSSR) play key roles in vertebrate reproduction.
Dong-Kyu Kim +7 more
core +2 more sources
Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.Abstract Mammalian reproductive function is dependent upon gonadal steroid hormone feedback within the hypothalamic–pituitary–gonadal (HPG) axis. In polycystic ovary syndrome (PCOS), impaired progesterone (P4) negative feedback leads to hyperactive pulsatile secretion of luteinising hormone (LH) and impaired reproductive function.
Kelly A. Glendining +4 more
wiley +1 more source
Dynamic Kisspeptin Receptor Trafficking Modulates Kisspeptin-Mediated Calcium Signaling [PDF]
Molecular Endocrinology, 2014 Abstract Kisspeptin receptor (KISS1R) signaling plays a critical role in the regulation of reproduction. We investigated the role of kisspeptin-stimulated KISS1R internalization, recycling, and degradation in the modulation of KISS1R signaling.
Le, Min +7 more
openaire +2 more sources
Neurokinin B and reproductive functions: 'KNDy neuron' model in mammals and the emerging story in fish [PDF]
, 2014 In mammals, neurokinin B (NKB), the gene product of the tachykinin family member TAC3, is known to be a key regulator for episodic release of luteinizing hormone (LH).
He, M, Hu, G, Lin, C, Wong, AOL
core +1 more source
Xenoestrogens Ethinyl Estradiol and Zearalenone Cause Precocious Puberty in Female Rats via Central Kisspeptin Signaling [PDF]
, 2015 Xenoestrogens from synthetic or natural origin represent an increasing risk of disrupted endocrine functions including the physiological activity of the hypothalamo-pituitary-gonad axis.
Csilla Molnár +9 more
core +1 more source