Results 91 to 100 of about 3,292,689 (405)

No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms [PDF]

, 1933
G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein ...
Chrousos, G. P., Karl, M., Reincke, Martin, Travis, W.   +3 more
core  

Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients [PDF]

, 1993
Glucocorticoid hormones suppress the secretion of ACTH evoked by secretagogues such as CRF and arginine vasopressin. In this study, we investigated the effects of glucocorticoids on ACTH release induced by oxytocin (OT) and on intracellular free calcium ...
Dayanithi, G., Gratzl, Manfred, Link, H.
core   +1 more source

A Core Head, Neck, and Neuroanatomy Syllabus for Physical Therapy Student Education

Clinical Anatomy, EarlyView.
ABSTRACT Head, neck, and neuroanatomy are essential components of physical therapy education due to their broad clinical applications. Detailed syllabi exist for medical students, yet none have been developed for physical therapy. This study aimed to produce an International Federation of Associations of Anatomists core head, neck, and neuroanatomy ...
Stephanie J. Woodley, Brooke Willoughby, Alexandra L. Webb, Natasha A. M. S. Flack, Laura Y. Whitburn   +4 more
wiley   +1 more source

Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors

Acta Neuropathologica Communications
We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug screening (HTS) and genomic sequencing methods. We examined 9 patient-derived PitNET primary cells in HTS.
Yijun Cheng, Yuting Dai, Hao Tang, Xingyu Lu, Jing Xie, Wanqun Xie, Qianqian Zhang, Yanting Liu, Shaojian Lin, Hong Yao, Hanbing Shang, Kun Yang, Hongyi Liu, Xuefeng Wu, Jianming Zhang, Xun Zhang, Li Xue, Zhe Bao Wu   +17 more
doaj   +1 more source

Acute hypopituitarism associated with periorbital swelling and cardiac dysfunction in a patient with pituitary tumor apoplexy: a case report

Journal of Medical Case Reports, 2017
Background Pituitary tumor apoplexy is a rare clinical syndrome caused by acute hemorrhage or infarction in a preexisting pituitary adenoma. It typically manifests as an acute episode of headache, visual disturbance, mental status changes, cranial nerve ...
Nobumasa Ohara, Yuichiro Yoneoka, Yasuhiro Seki, Katsuhiko Akiyama, Masataka Arita, Kazumasa Ohashi, Kazuo Suzuki, Toshinori Takada   +7 more
doaj   +1 more source

EPMA position paper in cancer:current overview and future perspectives [PDF]

, 2015
At present, a radical shift in cancer treatment is occurring in terms of predictive, preventive, and personalized medicine (PPPM). Individual patients will participate in more aspects of their healthcare.
Bubnov, Rostylav, Danesi, Romano, Desiderio, Dominic M., Grech, Godfrey, Hagan, Suzanne, Vittadini, Giorgio, Yoo, Byong Chul, Zhan, Xianquan   +7 more
core   +5 more sources

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease. [PDF]

, 2017
The CABLES1 cell cycle regulator participates in the adrenal-pituitary negative feedback, and its expression is reduced in corticotropinomas, pituitary tumors with a largely unexplained genetic basis.
Assié, Guillaume, Balsalobre, Aurelio, Bertherat, Jérôme, Chittiboina, Prashant, Dimopoulos, Aggeliki, Drouin, Jacques, Faucz, Fabio R, Gaillard, Stephan, Gam, Ryhem, Gauthier, Yves, Hernández-Ramírez, Laura C, Kay, Denise M, Lane, John, Lodish, Maya B, Mills, James L, Neou, Mario, Pankratz, Nathan, Stratakis, Constantine A, Trivellin, Giampaolo, Valdés, Nuria, Villa, Chiara   +20 more
core   +2 more sources

Clinical Safety of Extended Interval Dosing of Nivolumab in Patients with Melanoma

Clinical Pharmacology &Therapeutics, EarlyView.
Extended interval dosing regimens of immune checkpoint inhibitors have been implemented widely. However, their approval was mainly based on pharmacokinetic modeling and simulations. Consequently, comparative safety data of extended interval dosing regimens in a real‐world setting are limited.
Ruben Malmberg, Maaike M. Hofman, Fatima Ashad, Alaa Daloul, Stefani Oosterveld, Edwin A. Basak, Esther Oomen‐de Hoop, Astrid A. M. van der Veldt, Arjen Joosse, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen   +10 more
wiley   +1 more source

E-cadherin expression is associated with somatostatin analogue response in acromegaly [PDF]

, 2018
Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs)
Cano, David A., Castaño, Justo P., Dios, Elena, Flores Martínez, Álvaro, Ibáñez Costa, Alejandro, Japón Rodríguez, Miguel Ángel, Luque, Raúl M., Madrazo Atutxa, Ainara, Soto Moreno, Alfonso Manuel, Venegas Moreno, Eva, Vázquez Borrego, Mari C.   +10 more
core   +1 more source