Results 161 to 170 of about 3,128,159 (361)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Body surface temperatures as biomarkers of physiological environmental adaptation in wild birds and mammals

Biological Reviews, EarlyView.
ABSTRACT The ability of individuals to cope with their environment, and therefore the likelihood that they survive and pass on their genes (i.e. fitness), is largely determined by physiological state. Tracking physiological state in wild animals, however, is challenging.
Paul Jerem, L. Michael Romero
wiley   +1 more source

Regulation of growth hormone mRNA synthesis by 3,5,3'-triiodo-L-thyronine in cultured growth hormone-producing rat pituitary tumor cells (GC cells). Dissociation between nuclear iodothyronine receptor concentration and growth hormone mRNA synthesis during the deoxyribonucleic acid synthesis phase of the cell cycle.

, 1985
M. Kumarasiri, Martin I. Surks
openalex   +1 more source

GWAS Identifies SNPs Associated With Severe Adverse Events and Efficacy in Advanced Renal Cell Carcinoma Treated With Nivolumab

Cancer Science, EarlyView.
This study highlights the importance of germline genetic markers in predicting severe trAEs caused by nivolumab. Our findings support their potential to guide personalized immunotherapy and improve treatment safety and efficacy in advanced ccRCC and other cancers.
Tokiyoshi Tanegashima, Masaki Shiota, Shusuke Akamatsu, Hideaki Miyake, Masayuki Takahashi, Mototsugu Oya, Norihiko Tsuchiya, Naoya Masumori, Hideyasu Matsuyama, Wataru Obara, Nobuo Shinohara, Kiyohide Fujimoto, Masahiro Nozawa, Kojiro Ohba, Chikara Ohyama, Katsuyoshi Hashine, Tomomi Kamba, Koji Mita, Momokazu Gotoh, Shuichi Tatarano, Masato Fujisawa, Yoshihiko Tomita, Shoichiro Mukai, Keiichi Ito, Shoji Tokunaga, Masatoshi Eto, SNiP‐RCC investigators   +26 more
wiley   +1 more source

Targeting Autophagy for Pituitary Tumors. [PDF]

Cancers (Basel)
Yin E, Satou M, Tateno T.
europepmc   +1 more source

Reprimo (RPRM): A Tumor Suppressor That Induces Extrinsic Apoptosis via YAP Signaling

Cancer Science, EarlyView.
Reprimo (encoded by RPRM) is a p53 target gene that acts as a tumor suppressor and is frequently silenced by promoter hypermethylation in various cancers. Although previously known to function intracellularly as a tumor suppressor, recent studies revealed that secreted Reprimo also induces apoptosis in neighboring cells through a novel p53‐Reprimo ...
Masahiro Takikawa, Rieko Ohki
wiley   +1 more source

Return to work and factors influencing recovery after endoscopic transsphenoidal surgery for hypothalamic and pituitary tumors. [PDF]

Sci Rep
Suzuki K, Nakano Y, Inoue M, Sato K, Nagasaka S, Miyaoka R, Saito T, Yamamoto J.   +7 more
europepmc   +1 more source

Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells.

, 1982
S R Spindler, Synthia H. Mellon, John D. Baxter   +2 more
openalex   +1 more source

International Symposium on Pituitary Tumors [PDF]

, 1983

openalex   +1 more source

Development of a Minimum Dataset for the Global Monitoring of the Safety and Efficacy of Growth Hormone Replacement in Adults With Growth Hormone Deficiency (AGHD)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To identify the minimum dataset (MDS) for the monitoring of safety and effectiveness of GH in adults with growth hormone deficiency (AGHD). Design Systematic review and expert consensus. Methods Outcomes for AGHD were identified through a systematic literature search in PubMed, Science Direct and Cochrane.
Suet Ching Chen, Angela K. Lucas‐Herald, Ruoning Tang, Xanthippi Tseretopoulou, Malika Alimussina, Deno Andrews, Beverly M. K. Biller, Cesar L. Boguszewski, Jillian Bryce, Minglu Chen, Peter E. Clayton, Maria Fleseriu, Judith Gebauer, Ken K. Y. Ho, Jens Otto L. Jorgensen, Xiaoping Luo, Bradley S. Miller, Sebastian JCMM. Neggers, Lars Sävendahl, Katharina Schilbach, Christian J. Strasburger, Yutaka Takahashi, Diana Vitali, Kevin C. J. Yuen, Andrew R. Hoffman, Gudmundur Johannson, S. Faisal Ahmed   +26 more
wiley   +1 more source