Results 181 to 190 of about 101,292 (266)

Associations between anxiety, somatic pain and sleep disturbances in major depressive disorder and chronic pain: A cross‐sectional study with gender‐specific insights

open access: yesGeneral Psychiatry, Volume 39, Issue 3, June 2026.
ABSTRACT Background Major depressive disorder (MDD) and chronic pain (CP) demonstrate marked sex disparities, with higher prevalence and severity in females. However, the underlying mechanisms remain poorly understood. Aims We aimed to examine the intricate interplay among anxiety, physical pain and sleep disruptions in inpatients with depression and ...
Cuizhen Zhu   +10 more
wiley   +1 more source

MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Muscle atrophy occurs during physiological (i.e., fasting) and pathological conditions (i.e., cancer) and anticipates death. Since not all patients will undergo muscle wasting, it would be highly useful to identify them soon to intervene early.
Andrea D. Re Cecconi   +11 more
wiley   +1 more source

Impact of Frequent Immune‐Mediated Adverse Events on Treatment Continuity and Outcomes During Durvalumab Plus Tremelimumab Therapy for Unresectable Hepatocellular Carcinoma

open access: yesLiver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Durvalumab plus tremelimumab (Dur/Tre) is the first‐line treatment for unresectable hepatocellular carcinoma (uHCC). Immune‐mediated adverse events (imAEs) are common; however, the impact of specific imAE types on treatment persistence and outcomes remains unclear.
Tomomitsu Matono   +53 more
wiley   +1 more source

Combination Versus Monotherapy in Acute Anti‐LGI1 Encephalitis: A Real‐World Dose Optimization Analysis

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Combined IVIg and 500 mg/day IVMP achieve superior efficacy over monotherapies in anti‐LGI1 encephalitis, with optimal safety. Higher‐dose IVMP (1000 mg) accelerates response but increases adverse events, particularly in diabetic patients. Cognitive deficits persist post‐treatment, necessitating long‐term management.
Yao Tan   +6 more
wiley   +1 more source

Effect of environmental temperature on oxidative status, inflammatory response and endocannabinoid system at oestrus in dairy cows

open access: yesVeterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Heat stress (HS) poses a significant challenge to dairy production under climate change, as it compromises fertility, productivity and overall health in cows. This seasonal observational cross‐sectional study investigated how environmental temperature affects oxidative status, inflammatory responses and endocannabinoid system (ECS ...
Alice Carbonari   +10 more
wiley   +1 more source

Expression of MMP-2, MMP-9 and TIMP-2 in pituitary tumors and their relationship with cavernous sinus invasion. [PDF]

open access: yesEndocr Oncol
Thé B Freire AC   +10 more
europepmc   +1 more source

Validation of Immunoassays for Total Thyroxine and Free Thyroxine and Age and Sex‐Related Variation in Thyroid Hormone Serum Concentrations in Orangutans (Pongo sp.)

open access: yesJournal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT Background Thyroid disease is reported in orangutans, but to properly diagnose and manage these disorders, reference intervals for circulating thyroid hormones are needed. Methods Commercial immunoassay kits for total thyroxine (TT4) and free thyroxine (FT4) were validated for use in orangutans (Pongo spp.).
Melissa A. Fayette   +4 more
wiley   +1 more source

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