Results 171 to 180 of about 84,991 (218)

Advancing Immunization Strategies in Immunosuppressed Populations-Current Evidence, Clinical Challenges, and Future Directions. [PDF]

Vaccines (Basel)
Focosi D, Franchini M.
europepmc   +1 more source

A Transnasal Endoscope for Robotically Assisted Gastroscopy

Advanced Robotics Research, EarlyView.
This work introduces a 4.25 mm diameter magnetically navigated transnasal endoscope for upper gastrointestinal (GI) screening and intervention. The system enables precise remote steering throughout the upper GI tract and is demonstrated through in vitro and in vivo experiments, including the robotic execution of preprogrammed retroflexions, trans ...
Alexandre Mesot, Michelle Mattille, Sean Lyttle, Shannon M. Chan, Philip W. Y. Chiu, Quentin Boehler, Bradley J. Nelson   +6 more
wiley   +1 more source

Rethinking flow: the paradox of renoprotection without increased renal blood flow in cardiopulmonary bypass. [PDF]

J Thorac Dis
Mohan S, Shaju RA, Misra S, Sharma T, Sirivolu VK, Rajkumar A, Rodas-Camacho A, Zaidi A, Dhingra D, Khan I, Bhattacharya R, Pancholy V, Banerjee S, Ghosh S, Li S, Liao KK, Walther CP, Mondal NK.   +17 more
europepmc   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Minimum Area Confidence Set Optimality for Simultaneous Confidence Bands for Percentiles With Applications to Drug Shelf-Life Estimation. [PDF]

Stat Med
Wang L, Han Y, Liu W, Bretz F.
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Space-velocity-governed chemoselective pseudo-oxidation: a convergent flow platform for the synthesis of evocalcet. [PDF]

RSC Adv
Tsubogo T, Sakamoto R, Ishitani H, Kobayashi S.   +3 more
europepmc   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source